Gene: daz-1 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | daz-1 | ||||||||||||||||
NCBI Gene ID | : | 173931 | ||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||
Gene Synonyms | : | CE27175 | CELE_F56D1.7 | daz-1 | F56D1.7 | Protein DAZ-1 | WP:CE27175 Source: GPSDB |
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Gene Homologs | : | |||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_005745 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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DAZ protein 1 | Caenorhabditis elegans | Q20870 (UniProtKB/Swiss-Prot) | DAZ1_CAEEL (UniProtKB/Swiss-Prot) | RNA-binding protein that plays a central role in oogenesis, but not for spermatogenesis. Required for meiotic entry and germline differentiation, at the pachytene stage of meiosis I of female germline regardless of the sex of the soma. May act by regulating translation of specific mRNAs, possibly by binding to their 3'-UTR. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_000033 | Caenorhabditis elegans | Bristol N2 |
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increased | 8.81% | 21 | 19.3 | days | mean | 20 | ℃ | hermaphrodite | Mutation of daz-1 has no effect on life span. Other phenotypes: daz-1 mutants are sterile and have a gonad that contains small nuclei and no oocytes [ 10662646]. Sperm production is normal. Oocyte precursors arrest at meiotic prophase and undergo apoptosis. | Arantes-Oliveira et al. | 2002 | 11799246 | doi:10.1126/science.1065768 | Lifespan Observations Database (ID: 102) |
Homology Analysis
no homology analysis observation available
Sequences
DAZ1_CAEEL | Q20870 | DAZ protein 1 (Caenorhabditis elegans) from UniProtKB/Swiss-Prot Length: 499 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 DAZ1_CAEEL 1 MMSPPLRYQKDQQNQQHQQNQSQQAAHQMVSFMPQTPTSLPSTPIQLYPTGAAALIPAPPTYELIPNRIFVGGFPTSTTETELREHFEKFFAVKDVKMVKSLDGQSKGYGFITFETEDQAEEIRKLTPKQLEFRSRKLNLGPAIRKINSNSFQPSYAIATPSQLVAASPGPFSYAIPASPSPYSGYSYPASPQMFVYPPLRSQDQSRQQSEQQTTPQNSPTNLQHQQSPQVFFGGDQDPIRSYASAVAGVEKSEVSPEKHESVSPQPLLPNQNVLNTQYSQGQQQWNSNVQQQQQQQMDSNNGGPYYNENYSQGYTRPHPYQQFAQSGVYMNSQGMYHSSYSYMTPPLAPGQYPQMMSAPYWQQQQQHHQSHAYAGYNPAYNNWVGPSGDMNQFKQNPSNYFYQNYPGNFSQQHTMGNNENTFSLPLQAPRQGKKSRKPSECQDKKTKSPIKGARTERPSSSASTPDAKYQKNHRYPVHLSPLSASLQSLAISSPTKNN 499
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Arantes-Oliveira N, Apfeld J, Dillin A, Kenyon C:
Regulation of life-span by germ-line stem cells in Caenorhabditis elegans.
Science. 2002; 295: 502-5.
PubMed (ID: 11799246), doi:10.1126/science.1065768
MeSH Terms: Aging; Caenorhabditis elegans/cytology; Caenorhabditis elegans/physiology; Germ Cells/cytology; Longevity; Stem Cells/physiology
Sources
Ageing-related Data Sources
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot