Gene: pdk-1 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | pdk-1 | ||||||||||||||||||||||||||||||||
NCBI Gene ID | : | 180475 | ||||||||||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||||||||||
Gene Synonyms | : | CE28739 | CE28740 | CELE_H42K12.1 | H42K12.1 | H42K12.1a | H42K12.1b | pdk-1 | Protein PDK-1 | WP:CE28739 | WP:CE28740 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP001471 (Anopheles gambiae) | Os01g0872800 (Oryza sativa) | pdk-1 (Caenorhabditis elegans) | Pdk1 (Drosophila melanogaster) | PDPK1 (Arabidopsis thaliana) | PDPK1 (Bos taurus) | PDPK1 (Canis lupus familiaris) | PDPK1 (Gallus gallus) | PDPK1 (Homo sapiens) | Pdpk1 (Mus musculus) | Pdpk1 (Rattus norvegicus) | pdpk1b (Danio rerio) | PDPK2 (Arabidopsis thaliana) | ||||||||||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_005807 | ||||||||||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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3-phosphoinositide-dependent protein kinase 1 | Caenorhabditis elegans | Q9Y1J3 (UniProtKB/Swiss-Prot) | PDPK1_CAEEL (UniProtKB/Swiss-Prot) | Involved in the daf-2/insulin receptor-like transduction pathway, which controls longevity and prevents developmental arrest at the dauer stage. Phosphorylates and activates sgk-1, akt-1 and akt-2. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | |||||||||||||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | |||||||||||||||||||||||||
1 | OB_005704 | Caenorhabditis elegans |
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increased | 60.00% | unknown | Loss-of-function alleles extend lifespan by 60%. | Paradis et al. | 1999 | 10364160 | GenAge | |||||||||||||||||||||||||||||||||||
2 | OB_004209 | Caenorhabditis elegans | Bristol N2 |
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increased | 58.82% | 27 | 17 | days | mean | 25 | ℃ | Loss of function alleles extend life span by 60%. Other phenotypes: Mutants are dauer constitutive and a gain of function allele can suppress age-1 dauer constitutive phenotype [ 10364160]. Dauer constitutive phenotype of pdk-1(sa680) is suppressed by daf-16 [ 10364160]. | Paradis et al. | 1999 | 10364160 | Lifespan Observations Database (ID: 8) | |||||||||||||||||||||||||||||
3 | OB_003434 | Caenorhabditis elegans | N2 |
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increased | 26.64% | 318 | 251.1 | mean | 25 | ℃ | Lifespan of pdk-1(sa680) mutant on UV-killed OP50 was approximately 27% longer than N2 control on cdc-25.1 RNAi background. | Evans et al. | 2008 | 18782349 | doi:10.1111/j.1474-9726.2008.00435.x | Lifespan Observations Database (ID: 4858) | ||||||||||||||||||||||||||||
4 | OB_002449 | Caenorhabditis elegans | N2 |
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increased | 17.61% | 18.7 | 15.9 | median | 20 | ℃ | hermaphrodite | Median adult lifespan is increased in an oga-1 deletion strain while median adult life span is decreased upon ogt-1 deletion. The O-GlcNAc-mediated effect on nematode lifespan is dependent on the FoxO transcription factor DAF-16. | Rahman et al. | 2010 | 20952811 | Lifespan Observations Database (ID: 3710) | |||||||||||||||||||||||||||||
5 | OB_003415 | Caenorhabditis elegans | N2 |
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none | 4.12% | 118.9 | 114.2 | mean | 25 | ℃ | The long-lived loss-of-function mutant pdk-1(sa680) also had wildtype-like survival on PA14 in a cdc-25.1 RNAi Glp background. | Evans et al. | 2008 | 18782349 | doi:10.1111/j.1474-9726.2008.00435.x | Lifespan Observations Database (ID: 4840) | ||||||||||||||||||||||||||||
6 | OB_002447 | Caenorhabditis elegans | N2 |
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decreased | -6.92% | 14.8 | 15.9 | median | 20 | ℃ | hermaphrodite | Median adult lifespan is increased in an oga-1 deletion strain while median adult life span is decreased upon ogt-1 deletion. The O-GlcNAc-mediated effect on nematode lifespan is dependent on the FoxO transcription factor DAF-16. | Rahman et al. | 2010 | 20952811 | Lifespan Observations Database (ID: 3709) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
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1 | OB_008186 | 2 | The HomoloGene homology group 37643 contains 2 genes with experimental evidence for ageing relevance (PDPK1 - Homo sapiens | pdk-1 - Caenorhabditis elegans) and 11 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 37643 |
Sequences
PDPK1_CAEEL | Q9Y1J3 | 3-phosphoinositide-dependent protein kinase 1 (Caenorhabditis elegans) from UniProtKB/Swiss-Prot Length: 636 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 PDPK1_CAEEL 1 MEDLTPTNTSLDTTTTNNDTTSDREAAPTTLNLTPTASESENSLSPVTAEDLIAKSIKEGCPKRTSNDFMFLQSMGEGAYSQVFRCREVATDAMFAVKVLQKSYLNRHQKMDAIIREKNILTYLSQECGGHPFVTQLYTHFHDQARIYFVIGLVENGDLGESLCHFGSFDMLTSKFFASEILTGLQFLHDNKIVHRDMKPDNVLIQKDGHILITDFGSAQAFGGLQLSQEGFTDANQASSRSSDSGSPPPTRFYSDEEVPEENTARRTTFVGTALYVSPEMLADGDVGPQTDIWGLGCILFQCLAGQPPFRAVNQYHLLKRIQELDFSFPEGFPEEASEIIAKILVRDPSTRITSQELMAHKFFENVDWVNIANIKPPVLHAYIPATFGEPEYYSNIGPVEPGLDDRALFRLMNLGNDASASQPSTFRPSNVEHRGDPFVSEIAPRANSEAEKNRAARAQKLEEQRVKNPFHIFTNNSLILKQGYLEKKRGLFARRRMFLLTEGPHLLYIDVPNLVLKGEVPWTPCMQVELKNSGTFFIHTPNRVYYLFDLEKKADEWCKAINDVRKRYSVTIEKTFNSAMRDGTFGSIYGKKKSRKEMMREQKALRRKQEKEEKKALKAEQVSKKLSMQMDKKSP 636
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G:
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.
Genes Dev. 1999; 13: 1438-52.
PubMed (ID: 10364160), PubMed Central (ID: PMC316759)
MeSH Terms: Caenorhabditis elegans Proteins; Caenorhabditis elegans/enzymology; Caenorhabditis elegans/physiology; Helminth Proteins/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Protein-Serine-Threonine Kinases/metabolism; Signal Transduction - Evans EA, Chen WC, Tan MW:
The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans.
Aging Cell. 2008; 7: 879-93.
PubMed (ID: 18782349), PubMed Central (ID: PMC2630471), doi:10.1111/j.1474-9726.2008.00435.x
MeSH Terms: Aging/immunology; Caenorhabditis elegans Proteins/physiology; Caenorhabditis elegans/immunology; Immunity, Innate/genetics; Insulin/physiology; Receptor, Insulin/physiology; Signal Transduction/immunology - Rahman MM, Stuchlick O, El-Karim EG, Stuart R, Kipreos ET, Wells L:
Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans.
Aging (Albany NY). 2010; 2: 678-90.
PubMed (ID: 20952811), PubMed Central (ID: PMC2993798)
MeSH Terms: Acetylglucosamine/metabolism; Caenorhabditis elegans/physiology; Insulin/physiology; Longevity/physiology; Protein Processing, Post-Translational/physiology; Signal Transduction/physiology
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- UniProtKB/Swiss-Prot
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed