1 |
OB_003001 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Axenic medium |
Culture on non-bacterial, semi-dened, axenic food sources. |
|
increased |
126.39% |
32.6 |
14.4 |
days |
mean |
24 |
℃ |
hermaphrodite |
Comparisons of longevity of wild type and mutants grown on bacteria vs. axenic culture. |
Houthoofd et al. |
2003 |
12954481 |
|
Lifespan Observations Database (ID: 4335) |
2 |
OB_002290 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
74.19% |
54 |
31 |
days |
max |
20 |
℃ |
hermaphrodite |
Double mutation leads to increased (74%). maximum lifespan. |
Feng et al. |
2001 |
11709184 |
|
Lifespan Observations Database (ID: 3565) |
3 |
OB_002738 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
1 x 10^8 cells/mL. A 1000-fold reduction from control. UV-killed E. coli food source. |
|
increased |
63.01% |
28.2 |
17.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
Overexpression of DRR-2 has little effect on wild type life span but blunts life span extension from inhibition of TOR or from DR. |
Ching et al. |
2010 |
20456299 |
doi:10.1111/j.1474-9726.2010.00580.x |
Lifespan Observations Database (ID: 4032) |
4 |
OB_000940 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
e1406 mgDf50 |
unknown |
unknown |
|
|
|
increased |
60.92% |
56 |
34.8 |
days |
max |
15 |
℃ |
hermaphrodite |
Mutation increased maximum lifespan 61%. |
Gerisch et al. |
2001 |
11740945 |
|
Lifespan Observations Database (ID: 2247) |
5 |
OB_002739 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
1 x 10^7 cells/mL. A 10000-fold reduction from control. UV-killed E. coli food source. |
|
increased |
59.54% |
27.6 |
17.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
Overexpression of DRR-2 has little effect on wild type life span but blunts life span extension from inhibition of TOR or from DR. |
Ching et al. |
2010 |
20456299 |
doi:10.1111/j.1474-9726.2010.00580.x |
Lifespan Observations Database (ID: 4033) |
6 |
OB_002289 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
51.02% |
29.6 |
19.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Double mutation leads to increased mean (50%) lifespan. |
Feng et al. |
2001 |
11709184 |
|
Lifespan Observations Database (ID: 3564) |
7 |
OB_003165 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m27 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Caloric restriction |
Complete absence of bacterial food. |
|
increased |
34.62% |
35 |
26 |
days |
median |
20 |
℃ |
|
DR-FD does not require daf-16 and is additive with daf-2. DR-FD increases the lifespan of daf-16(m27) mutants. Median lifespans: N2 Fed, 19 days; N2 DR-FD, 26 days; daf-16 Fed, 16 days; daf-16 DR-FD, 23 days. Dietary restriction of daf-16 increases lifespan 35% relative to N2 restricted. |
Kaeberlein et al. |
2006 |
17081160 |
doi:10.1111/j.1474-9726.2006.00238.x |
Lifespan Observations Database (ID: 4561) |
8 |
OB_001614 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
increased |
33.85% |
25.7 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown decreased lifespan by 43% relative to daf-2(e1370) mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2949) |
9 |
OB_000017 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
increased |
31.12% |
25.7 |
19.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of daf-16 failed to prevent life span extension from deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1015) |
10 |
OB_002130 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cco-2 |
Caenorhabditis elegans |
176707 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
|
|
|
increased |
29.17% |
24.8 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 93% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3417) |
11 |
OB_002478 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx546 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
fer-15 |
Caenorhabditis elegans |
|
unknown |
b26 |
unknown |
unknown |
|
|
|
increased |
26.92% |
33 |
26 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). First experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3737) |
12 |
OB_002737 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
1 x 10^9 cells/mL. A 100-fold reduction from control. UV-killed E. coli food source. |
|
increased |
26.59% |
21.9 |
17.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
Overexpression of DRR-2 has little effect on wild type life span but blunts life span extension from inhibition of TOR or from DR. |
Ching et al. |
2010 |
20456299 |
doi:10.1111/j.1474-9726.2010.00580.x |
Lifespan Observations Database (ID: 4031) |
13 |
OB_002493 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
clk-1 |
Caenorhabditis elegans |
175729 |
unknown |
e2519 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
increased |
25.00% |
30 |
24 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Fourth experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3750) |
14 |
OB_002546 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
increased |
23.81% |
26 |
21 |
days |
max |
25 |
℃ |
hermaphrodite |
Triple mutation extended maximum lifespan 24%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3799) |
15 |
OB_001435 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
eat-2 |
Caenorhabditis elegans |
175072 |
loss of function |
ad1116 |
unknown |
unknown |
|
|
|
increased |
19.81% |
24.8 |
20.7 |
days |
mean |
|
|
hermaphrodite |
RNA inactivation decreased lifespan extension of mutant. |
Ghazi et al. |
2007 |
17392428 |
doi:10.1073/pnas.0700638104 |
Lifespan Observations Database (ID: 2748) |
16 |
OB_000641 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
eat-2 |
Caenorhabditis elegans |
175072 |
loss of function |
ad465 |
unknown |
unknown |
|
|
|
increased |
19.80% |
23.6 |
19.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutation of daf-16 fails to prevent life span extension from mutation of clk-1 or eat-2. |
Lakowski et al. |
1998 |
9789046 |
|
Lifespan Observations Database (ID: 1905) |
17 |
OB_001434 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
eat-2 |
Caenorhabditis elegans |
175072 |
loss of function |
ad1116 |
unknown |
unknown |
|
|
|
increased |
19.32% |
24.7 |
20.7 |
days |
mean |
|
|
hermaphrodite |
RNA inactivation decreased lifespan extension of mutant. |
Ghazi et al. |
2007 |
17392428 |
doi:10.1073/pnas.0700638104 |
Lifespan Observations Database (ID: 2747) |
18 |
OB_002345 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
increased |
19.23% |
21.7 |
18.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA interference suppressed mutant lifespan by 51% relative to mutant lifespan. |
Berman et al. |
2006 |
16530050 |
doi:10.1016/j.cell.2006.01.039 |
Lifespan Observations Database (ID: 3617) |
19 |
OB_000847 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
non-null recessive |
mu86 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation beginning at the 2nd day of adulthood. |
|
increased |
16.67% |
28 |
24 |
days |
median |
20 |
℃ |
hermaphrodite |
Dietary restriction by bacterial deprivation increases the life span of wild type and daf-16 mutants, but fails to increase the life span of hsf-1 mutants. |
Steinkraus et al. |
2008 |
18331616 |
doi:10.1111/j.1474-9726.2008.00385.x |
Lifespan Observations Database (ID: 2128) |
20 |
OB_003478 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1368 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
UV irradiation |
Worms were transferred to plates without food and exposed to 2000 J/m2 of UV. Worms were transferred back to fresh plates with food and scored every 12 hr for viabilit |
|
increased |
16.67% |
2.8 |
2.4 |
|
mean |
20 |
℃ |
|
Mean lifespan of daf-2(e1368);daf-16(mu86) double mutant under UV stress was 17% longer than N2 control. |
Takahashi et al. |
2011 |
21531333 |
doi:10.1016/j.cmet.2011.03.017 |
Lifespan Observations Database (ID: 4904) |
21 |
OB_002458 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx546 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
fer-15 |
Caenorhabditis elegans |
|
unknown |
b26 |
unknown |
unknown |
|
|
|
increased |
16.16% |
23 |
19.8 |
days |
mean |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). First experiment. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3719) |
22 |
OB_002349 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
increased |
14.29% |
20.8 |
18.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA interferenced suppressed lifespan 56% relative to double mutant lifespan. |
Berman et al. |
2006 |
16530050 |
doi:10.1016/j.cell.2006.01.039 |
Lifespan Observations Database (ID: 3620) |
23 |
OB_001202 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
- |
unknown |
unknown |
|
|
|
increased |
13.77% |
19 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Loss-of-function mutations increased lifespan 14%. |
Lans et al. |
2007 |
17187771 |
doi:10.1016/j.ydbio.2006.11.028 |
Lifespan Observations Database (ID: 2527) |
24 |
OB_000637 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
clk-1 |
Caenorhabditis elegans |
175729 |
loss of function |
e2519 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
|
|
increased |
12.98% |
23.5 |
20.8 |
days |
mean |
18 |
℃ |
hermaphrodite |
Mutation of daf-16 fails to prevent life span extension from mutation of clk-1 or eat-2. |
Lakowski et al. |
1998 |
9789046 |
|
Lifespan Observations Database (ID: 1901) |
25 |
OB_002342 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
increased |
12.69% |
22.2 |
19.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA interference suppressed mutant lifespan by 51% relative to mutant lifespan. |
Berman et al. |
2006 |
16530050 |
doi:10.1016/j.cell.2006.01.039 |
Lifespan Observations Database (ID: 3614) |
26 |
OB_002491 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx542 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m27 |
unknown |
unknown |
fer-15 |
Caenorhabditis elegans |
|
unknown |
b26 |
unknown |
unknown |
|
|
|
increased |
12.50% |
27 |
24 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Fourth experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3749) |
27 |
OB_002494 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
clk-1 |
Caenorhabditis elegans |
175729 |
unknown |
e2519 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m27 |
unknown |
unknown |
|
|
|
increased |
12.50% |
27 |
24 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Fourth experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3751) |
28 |
OB_002907 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf50 |
unknown |
unknown |
frh-1 |
Caenorhabditis elegans |
174002 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
11.95% |
17.8 |
15.9 |
days |
mean |
30 |
℃ |
hermaphrodite |
cep-1 is required to extend longevity in response to mild suppression of several bioenergetically relevant mitochondrial proteins, including frataxin the protein defective in patients with Friedreichs Ataxia. |
Ventura et al. |
2009 |
19416129 |
doi:10.1111/j.1474-9726.2009.00482.x |
Lifespan Observations Database (ID: 4227) |
29 |
OB_002472 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx542 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m27 |
unknown |
unknown |
fer-15 |
Caenorhabditis elegans |
|
unknown |
b26 |
unknown |
unknown |
|
|
|
increased |
11.62% |
22.1 |
19.8 |
days |
mean |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Fourth experiment. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3731) |
30 |
OB_002131 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
atp-4 |
Caenorhabditis elegans |
179025 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
|
|
|
increased |
11.46% |
21.4 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 67% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3418) |
31 |
OB_002512 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
clk-1 |
Caenorhabditis elegans |
175729 |
unknown |
e2519 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
increased |
11.11% |
30 |
27 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Fourth experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3768) |
32 |
OB_002513 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
clk-1 |
Caenorhabditis elegans |
175729 |
unknown |
e2519 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m27 |
unknown |
unknown |
|
|
|
increased |
11.11% |
30 |
27 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Fourth experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3769) |
33 |
OB_002352 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1368 |
unknown |
unknown |
|
|
|
increased |
10.99% |
20.2 |
18.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA interference suppressed lifespan extension by 33% relative to mutant lifespan. |
Berman et al. |
2006 |
16530050 |
doi:10.1016/j.cell.2006.01.039 |
Lifespan Observations Database (ID: 3623) |
34 |
OB_002134 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
asb-2 |
Caenorhabditis elegans |
180718 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
|
|
|
increased |
10.42% |
21.2 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 65% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3420) |
35 |
OB_003505 |
Caenorhabditis elegans |
N2DRM |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
loss of function |
mg44 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
|
|
increased |
10.00% |
|
|
|
mean |
20 |
℃ |
|
Mean lifespan of strain SR819 daf-16(m26);age-1(mg44) double mutant was approximately 10% longer than N2DRM control. |
Shmookler Reis et al. |
2011 |
21386131 |
|
Lifespan Observations Database (ID: 4932) |
36 |
OB_002543 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
increased |
9.52% |
23 |
21 |
days |
max |
25 |
℃ |
hermaphrodite |
Double mutation extended maximum lifespan 10%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3796) |
37 |
OB_003402 |
Caenorhabditis elegans |
N2DRM |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
loss of function |
mg44 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
- |
unknown |
unknown |
|
|
|
increased |
8.57% |
19 |
17.5 |
days |
mean |
20 |
℃ |
|
Lifespan of age-1(mg44);daf-16 double mutant was approximately 9% greater than control. |
Ayyadevara et al. |
2008 |
17996009 |
doi:10.1111/j.1474-9726.2007.00348.x |
Lifespan Observations Database (ID: 4829) |
38 |
OB_002479 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
increased |
8.11% |
40 |
37 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Second experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3738) |
39 |
OB_002499 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
increased |
8.11% |
40 |
37 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Second experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3756) |
40 |
OB_002473 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
clk-1 |
Caenorhabditis elegans |
175729 |
unknown |
e2519 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
increased |
8.08% |
21.4 |
19.8 |
days |
mean |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Fourth experiment. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3732) |
41 |
OB_001595 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
mu150 |
unknown |
unknown |
|
|
|
increased |
7.29% |
20.6 |
19.2 |
days |
mean |
25 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown decreased lifespan of daf-2 mutants by 35% relative to daf-2 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2931) |
42 |
OB_002355 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1368 |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
increased |
7.14% |
19.5 |
18.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA interference suppressed lifespan extension by 36% relative to double mutant. |
Berman et al. |
2006 |
16530050 |
doi:10.1016/j.cell.2006.01.039 |
Lifespan Observations Database (ID: 3626) |
43 |
OB_003504 |
Caenorhabditis elegans |
N2DRM |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
loss of function |
hx546 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
|
|
increased |
7.00% |
|
|
|
mean |
20 |
℃ |
|
Mean lifespan of strain SR819 daf-16(m26);age-1(hx546) double mutant was approximately 7% longer than N2DRM control. |
Shmookler Reis et al. |
2011 |
21386131 |
|
Lifespan Observations Database (ID: 4931) |
44 |
OB_002736 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
1 x 10^10 cells/mL. A 10-fold reduction from control. UV-killed E. coli food source. |
|
increased |
6.94% |
18.5 |
17.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
Overexpression of DRR-2 has little effect on wild type life span but blunts life span extension from inhibition of TOR or from DR. |
Ching et al. |
2010 |
20456299 |
doi:10.1111/j.1474-9726.2010.00580.x |
Lifespan Observations Database (ID: 4030) |
45 |
OB_000992 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
|
|
increased |
6.90% |
15.5 |
14.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutations extend lifespan by up to 7%. |
Hirose et al. |
2003 |
12571101 |
|
Lifespan Observations Database (ID: 2303) |
46 |
OB_002127 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
nuo-4 |
Caenorhabditis elegans |
176001 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
6.77% |
20.5 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 60% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3414) |
47 |
OB_002585 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
GFP |
Caenorhabditis elegans |
|
normal |
- |
unknown |
unknown |
old-1 |
Caenorhabditis elegans |
191737 |
normal |
mk1 |
unknown |
unknown |
|
|
|
increased |
6.67% |
16 |
15 |
days |
mean |
20 |
℃ |
hermaphrodite |
OLD-1::GFP expression in the reduction-of-function daf-16(m26) mutant background, removes the lifespan extension of OLD-1::GFP. |
Murakami et al. |
2001 |
11591319 |
|
Lifespan Observations Database (ID: 3863) |
48 |
OB_001201 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
- |
unknown |
unknown |
|
|
|
increased |
6.59% |
17.8 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Loss-of-function mutations increased lifespan 7%. |
Lans et al. |
2007 |
17187771 |
doi:10.1016/j.ydbio.2006.11.028 |
Lifespan Observations Database (ID: 2526) |
49 |
OB_000939 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
e1406 rh61rh411 |
unknown |
unknown |
|
|
|
increased |
6.32% |
37 |
34.8 |
days |
max |
15 |
℃ |
hermaphrodite |
Mutation had no significant effect on maximum lifespan. |
Gerisch et al. |
2001 |
11740945 |
|
Lifespan Observations Database (ID: 2246) |
50 |
OB_003499 |
Caenorhabditis elegans |
N2DRM |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
increased |
6.00% |
|
|
|
mean |
20 |
℃ |
|
Mean lifespan of strain SR818 daf-16(m26);daf-2(e1370) double mutant was approximately 6% shorter than N2DRM control. |
Shmookler Reis et al. |
2011 |
21386131 |
|
Lifespan Observations Database (ID: 4927) |
51 |
OB_003503 |
Caenorhabditis elegans |
N2DRM |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
loss of function |
hx546 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
|
|
increased |
6.00% |
|
|
|
median |
20 |
℃ |
|
Median lifespan of strain SR819 daf-16(m26);age-1(hx546) double mutant was approximately 6% longer than N2DRM control. |
Shmookler Reis et al. |
2011 |
21386131 |
|
Lifespan Observations Database (ID: 4930) |
52 |
OB_003506 |
Caenorhabditis elegans |
N2DRM |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
loss of function |
mg44 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
|
|
increased |
6.00% |
|
|
|
median |
20 |
℃ |
|
Median lifespan of strain SR819 daf-16(m26);age-1(mg44) double mutant was approximately 6% longer than N2DRM control. |
Shmookler Reis et al. |
2011 |
21386131 |
|
Lifespan Observations Database (ID: 4933) |
53 |
OB_002278 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
|
|
|
increased |
5.79% |
20.1 |
19 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutation has no significant effect on lifespan. |
Schafer et al. |
2006 |
16968739 |
doi:10.1242/jcs.03187 |
Lifespan Observations Database (ID: 3554) |
54 |
OB_002279 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
ifta-2 |
Caenorhabditis elegans |
189055 |
loss of function |
tm1724 |
unknown |
unknown |
|
|
|
increased |
5.00% |
19.95 |
19 |
days |
mean |
20 |
℃ |
hermaphrodite |
Double mutation extends lifespan about 5%. |
Schafer et al. |
2006 |
16968739 |
doi:10.1242/jcs.03187 |
Lifespan Observations Database (ID: 3555) |
55 |
OB_003498 |
Caenorhabditis elegans |
N2DRM |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
increased |
5.00% |
|
|
|
median |
20 |
℃ |
|
Median lifespan of strain SR818 daf-16(m26);daf-2(e1370) double mutant was approximately 5% shorter than N2DRM control. |
Shmookler Reis et al. |
2011 |
21386131 |
|
Lifespan Observations Database (ID: 4926) |
56 |
OB_002467 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m27 |
unknown |
unknown |
|
|
|
none |
4.55% |
20.7 |
19.8 |
days |
mean |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Fourth experiment. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3727) |
57 |
OB_002474 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
clk-1 |
Caenorhabditis elegans |
175729 |
unknown |
e2519 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m27 |
unknown |
unknown |
|
|
|
none |
4.55% |
20.7 |
19.8 |
days |
mean |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Fourth experiment. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3733) |
58 |
OB_002600 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
4 |
mg/ml |
|
|
none |
4.19% |
17.4 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3887) |
59 |
OB_001566 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
rps-15 |
Caenorhabditis elegans |
172693 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
none |
4.17% |
20 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan 40% relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2905) |
60 |
OB_002832 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf50 |
unknown |
unknown |
|
|
|
none |
4.17% |
15 |
14.4 |
|
mean |
20 |
℃ |
hermaphrodite |
Oxaloacetate supplementation increased lifespan in Caenorhabditis elegans. The increase was dependent on the transcription factor, FOXO DAF-16, and the energy sensor, AMP-activated protein kinase. |
Williams et al. |
2009 |
19793063 |
doi:10.1111/j.1474-9726.2009.00527.x |
Lifespan Observations Database (ID: 4120) |
61 |
OB_001597 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
mu150 |
unknown |
unknown |
|
|
|
none |
3.12% |
19.8 |
19.2 |
days |
mean |
25 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown decreased lifespan of daf-2 mutants by 44% relative to daf-2 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2933) |
62 |
OB_002465 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
spe-26 |
Caenorhabditis elegans |
177929 |
unknown |
hc138 |
unknown |
unknown |
|
|
|
none |
3.11% |
19.9 |
19.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Third experiment. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3725) |
63 |
OB_003405 |
Caenorhabditis elegans |
N2DRM |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
loss of function |
px546 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
- |
unknown |
unknown |
|
|
|
none |
2.86% |
18 |
17.5 |
days |
mean |
20 |
℃ |
|
Lifespan of daf-16;age-1(px546) double mutant was not signifiantly greater than control. |
Ayyadevara et al. |
2008 |
17996009 |
doi:10.1111/j.1474-9726.2007.00348.x |
Lifespan Observations Database (ID: 4831) |
64 |
OB_002632 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Valproic acid |
3 |
mM |
|
|
none |
2.47% |
16.6 |
16.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
The mood stabilizer and anticonvulsant valproic acid (VA) extended C. elegans lifespan. |
Evason et al. |
2008 |
18248662 |
doi:10.1111/j.1474-9726.2008.00375.x |
Lifespan Observations Database (ID: 3926) |
65 |
OB_001594 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
ife-2 |
Caenorhabditis elegans |
180393 |
loss of function |
ok306 |
unknown |
unknown |
|
|
|
none |
2.33% |
17.6 |
17.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA knockdown throughout whole life of eIF4E/ife-2(ok306) decreased lifespan 15% relative to ife-2 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2930) |
66 |
OB_001097 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
osm-3 |
Caenorhabditis elegans |
177141 |
unknown |
p802 |
unknown |
unknown |
|
|
|
none |
2.13% |
19.2 |
18.8 |
days |
mean |
20 |
℃ |
hermaphrodite |
Several (but not all) mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. Life span extension is generally partially or completely suppressed by mutation of daf-16. |
Apfeld et al. |
1999 |
10617200 |
doi:10.1038/45544 |
Lifespan Observations Database (ID: 2416) |
67 |
OB_008097 |
Caenorhabditis elegans |
daf-16(mu86) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
null mutant |
mu86 |
null mutant |
no |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
wildtype |
yes |
|
|
|
none |
2.00% |
24.5 |
24 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
68 |
OB_003408 |
Caenorhabditis elegans |
pha-1(e2123) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
none |
1.57% |
45.2 |
44.5 |
|
mean |
25 |
℃ |
|
Daf-16 RNAi knock-down in sterile animals with intact germline proliferation, pha-1(e2123), resulted in survival kinetics that was indistinguishable from control. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4834) |
69 |
OB_002422 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
lin-14 |
Caenorhabditis elegans |
181337 |
gain of function |
n179ts |
unknown |
unknown |
|
|
|
none |
0.00% |
12 |
12 |
days |
max |
25 |
℃ |
hermaphrodite |
RNA knockdown had no significant effect. |
Boehm et al. |
2005 |
16373574 |
doi:10.1126/science.1115596 |
Lifespan Observations Database (ID: 3687) |
70 |
OB_002476 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
none |
0.00% |
26 |
26 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). First experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3735) |
71 |
OB_002483 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
none |
0.00% |
28 |
28 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Third experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3741) |
72 |
OB_002486 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
none |
0.00% |
24 |
24 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Fourth experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3744) |
73 |
OB_002487 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m27 |
unknown |
unknown |
|
|
|
none |
0.00% |
24 |
24 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Fourth experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3745) |
74 |
OB_002495 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m27 |
unknown |
unknown |
spe-26 |
Caenorhabditis elegans |
177929 |
unknown |
it118 |
unknown |
unknown |
|
|
|
none |
0.00% |
24 |
24 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Fourth experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3752) |
75 |
OB_002498 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx546 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
fer-15 |
Caenorhabditis elegans |
|
unknown |
b26 |
unknown |
unknown |
|
|
|
none |
0.00% |
33 |
33 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). First experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3755) |
76 |
OB_002501 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx546 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
none |
0.00% |
37 |
37 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Second experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3758) |
77 |
OB_002502 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
none |
0.00% |
31 |
31 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Third experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3759) |
78 |
OB_002505 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
spe-26 |
Caenorhabditis elegans |
177929 |
unknown |
hc138 |
unknown |
unknown |
|
|
|
none |
0.00% |
31 |
31 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Third experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3761) |
79 |
OB_002507 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m27 |
unknown |
unknown |
|
|
|
none |
0.00% |
27 |
27 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Fourth experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3763) |
80 |
OB_002511 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx542 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m27 |
unknown |
unknown |
fer-15 |
Caenorhabditis elegans |
|
unknown |
b26 |
unknown |
unknown |
|
|
|
none |
0.00% |
27 |
27 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Fourth experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3767) |
81 |
OB_002594 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
4 |
mg/ml |
|
|
none |
0.00% |
16.7 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3881) |
82 |
OB_002595 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Ethosuximide |
2 |
mg/ml |
|
|
none |
0.00% |
16.7 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3882) |
83 |
OB_002599 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trimethadione |
2 |
mg/ml |
|
|
none |
0.00% |
16.7 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3886) |
84 |
OB_003667 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
|
|
|
none |
0.00% |
15 |
15 |
days |
median |
25 |
℃ |
hermaphrodite |
Mutation of tdp-1 requires daf-16 to extend life span. |
Zhang et al. |
2012 |
22232551 |
doi:10.1074/jbc.M111.311977 |
Lifespan Observations Database (ID: 5187) |
85 |
OB_003668 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
tdp-1 |
Caenorhabditis elegans |
174436 |
unknown |
ok781 |
unknown |
unknown |
|
|
|
none |
0.00% |
15 |
15 |
days |
median |
25 |
℃ |
hermaphrodite |
Mutation of tdp-1 requires daf-16 to extend life span. |
Zhang et al. |
2012 |
22232551 |
doi:10.1074/jbc.M111.311977 |
Lifespan Observations Database (ID: 5188) |
86 |
OB_002456 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
none |
-0.51% |
19.7 |
19.8 |
days |
mean |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). First experiment. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3717) |
87 |
OB_001098 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
osm-5 |
Caenorhabditis elegans |
180585 |
unknown |
p813 |
unknown |
unknown |
|
|
|
none |
-0.53% |
18.7 |
18.8 |
days |
mean |
20 |
℃ |
hermaphrodite |
Several (but not all) mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. Life span extension is generally partially or completely suppressed by mutation of daf-16. |
Apfeld et al. |
1999 |
10617200 |
doi:10.1038/45544 |
Lifespan Observations Database (ID: 2417) |
88 |
OB_002630 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
|
|
none |
-0.62% |
16.1 |
16.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
The mood stabilizer and anticonvulsant valproic acid (VA) extended C. elegans lifespan. |
Evason et al. |
2008 |
18248662 |
doi:10.1111/j.1474-9726.2008.00375.x |
Lifespan Observations Database (ID: 3924) |
89 |
OB_002527 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
none |
-0.91% |
10.9 |
11 |
days |
mean |
25 |
℃ |
hermaphrodite |
Double mutation had no significant effect on lifespan. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3781) |
90 |
OB_008126 |
Caenorhabditis elegans |
daf-16(mu86) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
null mutant |
mu86 |
null mutant |
no |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
wildtype |
yes |
|
|
|
none |
-1.00% |
16.55 |
16.71 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
91 |
OB_004270 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
none |
-1.03% |
19.2 |
19.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of vhl-1 in daf-16(mu86) animals resulted in a life span that was comparable to wild type animals but longer than daf-16(mu86) animals. This experiment supports the model that life span extension from reduced vhl-1 activity increases life span by a DAF-16-independent mechanism. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 967) |
92 |
OB_001598 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
mu150 |
unknown |
unknown |
|
|
|
none |
-1.56% |
18.9 |
19.2 |
days |
mean |
25 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown decreased lifespan of daf-2 mutants by 42% relative to daf-2 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2934) |
93 |
OB_008125 |
Caenorhabditis elegans |
daf-16(mu86) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
null mutant |
mu86 |
null mutant |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
none |
-2.00% |
16.35 |
16.71 |
day |
mean |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
94 |
OB_002463 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
none |
-2.07% |
18.9 |
19.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Third experiment. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3723) |
95 |
OB_001596 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
mu150 |
unknown |
unknown |
|
|
|
none |
-2.08% |
18.8 |
19.2 |
days |
mean |
25 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown decreased lifespan of daf-2 mutants by 40% relative to daf-2 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2932) |
96 |
OB_002462 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx546 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
none |
-2.36% |
20.7 |
21.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Second experiment. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3722) |
97 |
OB_001213 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
- |
unknown |
unknown |
gpa-11 |
Caenorhabditis elegans |
173759 |
over-expression |
pkls540 |
unknown |
unknown |
odr-3 |
Caenorhabditis elegans |
179806 |
loss of function |
- |
unknown |
unknown |
|
|
|
none |
-2.99% |
16.2 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Loss of function mutation of daf-16 and odr-3 and over-expression of gpa-11 decreased lifespan 3%. |
Lans et al. |
2007 |
17187771 |
doi:10.1016/j.ydbio.2006.11.028 |
Lifespan Observations Database (ID: 2537) |
98 |
OB_002466 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
none |
-3.03% |
19.2 |
19.8 |
days |
mean |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Fourth experiment. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3726) |
99 |
OB_001162 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf50 |
unknown |
unknown |
|
|
|
none |
-3.33% |
17.4 |
18 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2491) |
100 |
OB_000902 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
e1406 rh61rh411 |
unknown |
unknown |
|
|
|
none |
-3.60% |
24.1 |
25 |
days |
mean |
15 |
℃ |
hermaphrodite |
Mutation did not produce a significant difference. |
Gerisch et al. |
2001 |
11740945 |
|
Lifespan Observations Database (ID: 2205) |
101 |
OB_003470 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1368 |
unknown |
unknown |
|
|
|
none |
-3.70% |
7.8 |
8.1 |
|
mean |
37 |
℃ |
|
Mean lifespan of daf-2(e1368);daf-16(mu86) double mutant under heat stress was 4% shorter than N2 control. |
Takahashi et al. |
2011 |
21531333 |
doi:10.1016/j.cmet.2011.03.017 |
Lifespan Observations Database (ID: 4898) |
102 |
OB_002234 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cco-1 |
Caenorhabditis elegans |
172832 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
|
|
|
none |
-3.95% |
14.6 |
15.2 |
days |
mean |
25 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 49% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3510) |
103 |
OB_002598 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Ethosuximide |
0.5 |
mg/ml |
|
|
none |
-4.19% |
16 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3885) |
104 |
OB_002460 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
none |
-4.25% |
20.3 |
21.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Second experiment. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3720) |
105 |
OB_002235 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
atp-3 |
Caenorhabditis elegans |
172195 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
|
|
|
none |
-4.61% |
14.5 |
15.2 |
days |
mean |
25 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 48% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3511) |
106 |
OB_002230 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
rab-10 |
Caenorhabditis elegans |
266836 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-5.26% |
14.4 |
15.2 |
days |
mean |
25 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 47% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3507) |
107 |
OB_003485 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
abtm-1 |
Caenorhabditis elegans |
171807 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
|
|
|
decreased |
-5.26% |
18 |
19 |
days |
mean |
20 |
℃ |
|
RNAi knockdown of abtm-1 in daf-16(mu86) mutant slightly increased lifespan relative to daf-16 mutant control and shortened lifespan approximately 5% relative to N2 lifespan control. |
González-Cabo et al. |
2011 |
21464130 |
doi:10.1074/jbc.M110.211201 |
Lifespan Observations Database (ID: 4910) |
108 |
OB_001200 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
- |
unknown |
unknown |
|
|
|
decreased |
-5.39% |
15.8 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Loss-of-function mutations decreased lifespan 5%. |
Lans et al. |
2007 |
17187771 |
doi:10.1016/j.ydbio.2006.11.028 |
Lifespan Observations Database (ID: 2525) |
109 |
OB_002418 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
lin-14 |
Caenorhabditis elegans |
181337 |
gain of function |
n179ts |
unknown |
unknown |
|
|
|
decreased |
-5.62% |
8.4 |
8.9 |
days |
mean |
25 |
℃ |
hermaphrodite |
RNA knockdown had no significant effect on lifespan. |
Boehm et al. |
2005 |
16373574 |
doi:10.1126/science.1115596 |
Lifespan Observations Database (ID: 3683) |
110 |
OB_008096 |
Caenorhabditis elegans |
daf-16(mu86) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
null mutant |
mu86 |
null mutant |
no |
|
Compound Name |
Quantity |
Quantity Unit |
N-acetyl-cysteine |
2 |
mM |
|
|
decreased |
-6.00% |
22.5 |
24 |
day |
maximum |
|
|
hermaphrodite |
|
Zarse et al. |
2012 |
22482728 |
doi:10.1016/j.cmet.2012.02.013 |
AgeFactDB Curator |
111 |
OB_001578 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
rsks-1 |
Caenorhabditis elegans |
176554 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-6.25% |
18 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan 18% relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2916) |
112 |
OB_002126 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
nuo-3 |
Caenorhabditis elegans |
178404 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-6.25% |
18 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 40% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3413) |
113 |
OB_002417 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-6.74% |
8.3 |
8.9 |
days |
mean |
25 |
℃ |
hermaphrodite |
RNA knockdown decreased lifespan approximately 6%. |
Boehm et al. |
2005 |
16373574 |
doi:10.1126/science.1115596 |
Lifespan Observations Database (ID: 3682) |
114 |
OB_002439 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
oga-1 |
Caenorhabditis elegans |
181164 |
deletion / null |
ok1207 |
unknown |
unknown |
|
|
|
decreased |
-6.92% |
14.8 |
15.9 |
|
median |
20 |
℃ |
hermaphrodite |
Median adult lifespan is increased in an oga-1 deletion strain while median adult life span is decreased upon ogt-1 deletion. The O-GlcNAc-mediated effect on nematode lifespan is dependent on the FoxO transcription factor DAF-16. |
Rahman et al. |
2010 |
20952811 |
|
Lifespan Observations Database (ID: 3701) |
115 |
OB_002830 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf50 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Oxaloacetate |
8 |
mM |
|
|
decreased |
-6.94% |
13.4 |
14.4 |
|
mean |
20 |
℃ |
hermaphrodite |
Oxaloacetate supplementation increased lifespan in Caenorhabditis elegans. The increase was dependent on the transcription factor, FOXO DAF-16, and the energy sensor, AMP-activated protein kinase. |
Williams et al. |
2009 |
19793063 |
doi:10.1111/j.1474-9726.2009.00527.x |
Lifespan Observations Database (ID: 4119) |
116 |
OB_001163 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf50 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
decreased |
-7.22% |
16.7 |
18 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2492) |
117 |
OB_001297 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-7.25% |
19.2 |
20.7 |
days |
mean |
|
|
hermaphrodite |
RNA interference in adulthood decreased the lifespan of N2. |
Ghazi et al. |
2007 |
17392428 |
doi:10.1073/pnas.0700638104 |
Lifespan Observations Database (ID: 2620) |
118 |
OB_001095 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-10 |
Caenorhabditis elegans |
184883 |
unknown |
m79 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
|
|
decreased |
-7.45% |
17.4 |
18.8 |
days |
mean |
20 |
℃ |
hermaphrodite |
Several (but not all) mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. Life span extension is generally partially or completely suppressed by mutation of daf-16. |
Apfeld et al. |
1999 |
10617200 |
doi:10.1038/45544 |
Lifespan Observations Database (ID: 2414) |
119 |
OB_001099 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
tax-4 |
Caenorhabditis elegans |
176297 |
unknown |
p678 |
unknown |
unknown |
|
|
|
decreased |
-7.98% |
17.3 |
18.8 |
days |
mean |
20 |
℃ |
hermaphrodite |
Several (but not all) mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. Life span extension is generally partially or completely suppressed by mutation of daf-16. |
Apfeld et al. |
1999 |
10617200 |
doi:10.1038/45544 |
Lifespan Observations Database (ID: 2418) |
120 |
OB_002633 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Valproic acid |
0.6 |
mM |
|
|
decreased |
-8.02% |
14.9 |
16.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
The mood stabilizer and anticonvulsant valproic acid (VA) extended C. elegans lifespan. |
Evason et al. |
2008 |
18248662 |
doi:10.1111/j.1474-9726.2008.00375.x |
Lifespan Observations Database (ID: 3927) |
121 |
OB_000938 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mgDf90 |
unknown |
unknown |
|
|
|
decreased |
-8.05% |
32 |
34.8 |
days |
max |
15 |
℃ |
hermaphrodite |
Mutation had no significant effect on maximum lifespan. |
Gerisch et al. |
2001 |
11740945 |
|
Lifespan Observations Database (ID: 2245) |
122 |
OB_002132 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
atp-5 |
Caenorhabditis elegans |
179541 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
|
|
|
decreased |
-8.33% |
17.6 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 38% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3419) |
123 |
OB_000636 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
|
|
decreased |
-8.65% |
19 |
20.8 |
days |
mean |
18 |
℃ |
hermaphrodite |
Mutation of daf-16 fails to prevent life span extension from mutation of clk-1 or eat-2. |
Lakowski et al. |
1998 |
9789046 |
|
Lifespan Observations Database (ID: 1900) |
124 |
OB_001572 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
rps-22 |
Caenorhabditis elegans |
175338 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-8.85% |
17.5 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan 22% relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2910) |
125 |
OB_002129 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cchl-1 |
Caenorhabditis elegans |
174713 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
|
|
|
decreased |
-8.85% |
17.5 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 32% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3416) |
126 |
OB_000018 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
decreased |
-8.95% |
23.4 |
25.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of daf-16 failed to prevent life span extension from deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1016) |
127 |
OB_001152 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf50 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Dimethyl sulfoxide |
0 |
- |
|
|
decreased |
-9.28% |
16.33 |
18 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2482) |
128 |
OB_002282 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
|
|
decreased |
-9.68% |
28 |
31 |
days |
max |
20 |
℃ |
hermaphrodite |
Mutation leads to maximum lifespan decrease of 10%. |
Feng et al. |
2001 |
11709184 |
|
Lifespan Observations Database (ID: 3558) |
129 |
OB_002231 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
nuo-2 |
Caenorhabditis elegans |
172363 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-9.87% |
13.7 |
15.2 |
days |
mean |
25 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 40% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3508) |
130 |
OB_002232 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cyc-1 |
Caenorhabditis elegans |
172582 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
|
|
|
decreased |
-9.87% |
13.7 |
15.2 |
days |
mean |
25 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 40% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3509) |
131 |
OB_003475 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1368 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Oxidative stress |
10 mM hydrogen peroxide diluted in S buffer |
|
decreased |
-10.00% |
2.7 |
3 |
|
mean |
20 |
℃ |
|
Mean lifespan of daf-2(e1368);daf-16(mu86) mutant under oxidative stress was 10% shorter than N2 control. |
Takahashi et al. |
2011 |
21531333 |
doi:10.1016/j.cmet.2011.03.017 |
Lifespan Observations Database (ID: 4901) |
132 |
OB_002438 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
|
|
decreased |
-10.06% |
14.3 |
15.9 |
|
median |
20 |
℃ |
hermaphrodite |
Median adult lifespan is increased in an oga-1 deletion strain while median adult life span is decreased upon ogt-1 deletion. The O-GlcNAc-mediated effect on nematode lifespan is dependent on the FoxO transcription factor DAF-16. |
Rahman et al. |
2010 |
20952811 |
|
Lifespan Observations Database (ID: 3700) |
133 |
OB_001008 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
|
|
decreased |
-10.32% |
13.9 |
15.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
When germline-deficient animals lacking somatic reproductive tissues are given dafachronic acid, their expression of DAF-12/NHR-dependent target genes is restored and their lifespan is increased. |
Yamawaki et al. |
2010 |
20824162 |
doi:10.1371/journal.pbio.1000468 |
Lifespan Observations Database (ID: 2326) |
134 |
OB_003000 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
decreased |
-10.42% |
12.9 |
14.4 |
days |
mean |
24 |
℃ |
hermaphrodite |
Comparisons of longevity of wild type and mutants grown on bacteria vs. axenic culture. |
Houthoofd et al. |
2003 |
12954481 |
|
Lifespan Observations Database (ID: 4334) |
135 |
OB_000797 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
unknown |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-10.53% |
17 |
19 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutations in daf-16 suppress life-extension caused by mutations in daf-2. |
Kenyon et al. |
1993 |
8247153 |
doi:10.1038/366461a0 |
Lifespan Observations Database (ID: 2054) |
136 |
OB_000798 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
|
|
decreased |
-10.53% |
17 |
19 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutation of daf-16 suppresses life span extension from mutation of daf-2. |
Kenyon et al. |
1993 |
8247153 |
doi:10.1038/366461a0 |
Lifespan Observations Database (ID: 2055) |
137 |
OB_003482 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
|
|
|
decreased |
-10.53% |
17 |
19 |
days |
mean |
20 |
℃ |
|
Mean lifespan of daf-16(mu86) mutant was approximately 11% shorter than N2 lifespan. |
González-Cabo et al. |
2011 |
21464130 |
doi:10.1074/jbc.M110.211201 |
Lifespan Observations Database (ID: 4908) |
138 |
OB_003483 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ctl-2 |
Caenorhabditis elegans |
175085 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
|
|
|
decreased |
-10.53% |
17 |
19 |
days |
mean |
20 |
℃ |
|
RNAi knockdown of cat in daf-16(mu86) mutant had no significant effect on lifespan relative to daf-16 mutant control, approximately 11% shorter than N2 lifespan control. |
González-Cabo et al. |
2011 |
21464130 |
doi:10.1074/jbc.M110.211201 |
Lifespan Observations Database (ID: 4909) |
139 |
OB_002485 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
spe-26 |
Caenorhabditis elegans |
177929 |
unknown |
hc138 |
unknown |
unknown |
|
|
|
decreased |
-10.71% |
25 |
28 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Third experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3743) |
140 |
OB_002530 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
decreased |
-10.91% |
9.8 |
11 |
days |
mean |
25 |
℃ |
hermaphrodite |
Triple mutation shortened lifespan 10%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3784) |
141 |
OB_002506 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
decreased |
-11.11% |
24 |
27 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Fourth experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3762) |
142 |
OB_002515 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m27 |
unknown |
unknown |
spe-26 |
Caenorhabditis elegans |
177929 |
unknown |
it118 |
unknown |
unknown |
|
|
|
decreased |
-11.11% |
24 |
27 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Fourth experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3770) |
143 |
OB_000639 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
|
|
decreased |
-11.68% |
17.4 |
19.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutation of daf-16 fails to prevent life span extension from mutation of clk-1 or eat-2. |
Lakowski et al. |
1998 |
9789046 |
|
Lifespan Observations Database (ID: 1903) |
144 |
OB_003787 |
Caenorhabditis elegans |
daf-2(e1370) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Heat stress |
35 degrees |
|
decreased |
-11.76% |
15 |
17 |
|
mean |
35 |
℃ |
|
RNAi knockdown of daf-16 decreased lifespan of daf-2(e1370) worms by approximately 12% under heat stress. |
Maman et al. |
2013 |
23554491 |
doi:10.1523/JNEUROSCI.4023-12.2013 |
Lifespan Observations Database (ID: 5367) |
145 |
OB_003788 |
Caenorhabditis elegans |
daf-2(e1370) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Heat stress |
35 degrees |
|
decreased |
-11.76% |
15 |
17 |
|
mean |
35 |
℃ |
|
RNAi knockdown of gtr-1 3'UTR decreased lifespan of daf-2(e1370) worms by approximately 12% under heat stress. |
Maman et al. |
2013 |
23554491 |
doi:10.1523/JNEUROSCI.4023-12.2013 |
Lifespan Observations Database (ID: 5368) |
146 |
OB_001335 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
- |
unknown |
unknown |
|
|
|
decreased |
-11.83% |
16.4 |
18.6 |
days |
mean |
|
|
hermaphrodite |
Mutant decreases lifespan by 12%. |
Ghazi et al. |
2007 |
17392428 |
doi:10.1073/pnas.0700638104 |
Lifespan Observations Database (ID: 2655) |
147 |
OB_002123 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
ril-1 |
Caenorhabditis elegans |
179958 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-11.98% |
16.9 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 32% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3410) |
148 |
OB_001010 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Dafachronic acid |
0 |
- |
|
|
decreased |
-12.26% |
13.6 |
15.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
When germline-deficient animals lacking somatic reproductive tissues are given dafachronic acid, their expression of DAF-12/NHR-dependent target genes is restored and their lifespan is increased. |
Yamawaki et al. |
2010 |
20824162 |
doi:10.1371/journal.pbio.1000468 |
Lifespan Observations Database (ID: 2332) |
149 |
OB_001589 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
let-363 |
Caenorhabditis elegans |
172167 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-12.50% |
16.8 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown extended lifespan 11% relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2926) |
150 |
OB_000883 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
non-null semi-dominant |
m26 |
unknown |
unknown |
|
|
|
decreased |
-13.04% |
18 |
20.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Semi-dominant mutation decreases lifespan by approximately 13%. |
Malone et al. |
1996 |
8807293 |
|
Lifespan Observations Database (ID: 2189) |
151 |
OB_002283 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
|
|
decreased |
-13.27% |
17 |
19.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutation leads to a lifespan decrease of 13%. |
Feng et al. |
2001 |
11709184 |
|
Lifespan Observations Database (ID: 3559) |
152 |
OB_001151 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf50 |
unknown |
unknown |
|
|
|
decreased |
-13.33% |
15.6 |
18 |
days |
mean |
20 |
℃ |
hermaphrodite |
0.5% and 2% DMSO extended the lifespan of C. elegans. Treatment with 0.5% DMSO did not affect the progeny number or the lifespan of C. elegans under thermal stress. E expression levels of hsp-16.2, hsp-70, lys-7, old-1, and sod-5 were enhanced by 2.5, 2.9, 1.3, 2.3, and 4.5-fold, respectively, after treatment with 0.5% DMSO. Genetic analysis using mutants of aging-related genes showed that lifespan extension in C. elegans by DMSO was dependent on sir-2.1 and daf-16 but not eat-2 or hsf-1. |
Wang et al. |
2010 |
20828537 |
doi:10.1016/j.bbrc.2010.08.113 |
Lifespan Observations Database (ID: 2481) |
153 |
OB_001569 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
rps-15 |
Caenorhabditis elegans |
172693 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-13.54% |
16.6 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan 18% relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2908) |
154 |
OB_000897 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mgDf90 |
unknown |
unknown |
|
|
|
decreased |
-13.60% |
21.6 |
25 |
days |
mean |
15 |
℃ |
hermaphrodite |
Mutation decreased lifespan approximately 14% |
Gerisch et al. |
2001 |
11740945 |
|
Lifespan Observations Database (ID: 2200) |
155 |
OB_002328 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
glp-1 |
Caenorhabditis elegans |
176286 |
loss of function |
e2141ts |
unknown |
unknown |
|
|
|
decreased |
-13.74% |
15.7 |
18.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA interference suppressed glp-1 life-extension by 21% relative to mutant lifespan. |
Berman et al. |
2006 |
16530050 |
doi:10.1016/j.cell.2006.01.039 |
Lifespan Observations Database (ID: 3601) |
156 |
OB_002596 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
|
|
decreased |
-13.77% |
14.4 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3883) |
157 |
OB_002597 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
|
|
|
decreased |
-13.77% |
14.4 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
The anti-convulsant compounds ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes. |
Evason et al. |
2005 |
15653505 |
doi:10.1126/science.1105299 |
Lifespan Observations Database (ID: 3884) |
158 |
OB_001259 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
glp-1 |
Caenorhabditis elegans |
176286 |
loss of function |
e2141ts |
unknown |
unknown |
|
|
|
decreased |
-14.01% |
17.8 |
20.7 |
days |
mean |
|
|
hermaphrodite |
RNA interference in adulthood decreased the lifespan of glp-1(e2141ts) mutants. |
Ghazi et al. |
2007 |
17392428 |
doi:10.1073/pnas.0700638104 |
Lifespan Observations Database (ID: 2587) |
159 |
OB_002117 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
sams-1 |
Caenorhabditis elegans |
181370 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-14.58% |
16.4 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 30% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3405) |
160 |
OB_001212 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
- |
unknown |
unknown |
gpa-11 |
Caenorhabditis elegans |
173759 |
over-expression |
pkls540 |
unknown |
unknown |
|
|
|
decreased |
-14.97% |
14.2 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Loss of function mutation of daf-16 and over-expression of gpa-11 decreased lifespan 15%. |
Lans et al. |
2007 |
17187771 |
doi:10.1016/j.ydbio.2006.11.028 |
Lifespan Observations Database (ID: 2536) |
161 |
OB_001494 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
mgDf50 |
unknown |
unknown |
|
|
|
decreased |
-14.99% |
14.86 |
17.48 |
days |
mean |
20 |
℃ |
hermaphrodite |
Two redundant homologues of the klotho gene exist in C. elegans and encode predicted proteins homologous to the glucosidase-like KL1 domain of mammalian Klotho. Knock-down of both klotho homologs by RNAi shortens lifespan. Klotho requires EGL-15 (FGFR) and EGL-17 to promote longevity |
Château et al. |
2010 |
20844315 |
|
Lifespan Observations Database (ID: 2840) |
162 |
OB_003780 |
Caenorhabditis elegans |
CF512 (fer-15(b26)II |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-15.33% |
14.41 |
17.02 |
days |
mean |
20 |
℃ |
|
RNAi knockdown of daf-16 decreased lifespan of CF512 (fer-15(b26)II worms by 15%. |
Maman et al. |
2013 |
23554491 |
doi:10.1523/JNEUROSCI.4023-12.2013 |
Lifespan Observations Database (ID: 5360) |
163 |
OB_001492 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C50F7.10 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
mgDf50 |
unknown |
unknown |
E02H9.5 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-15.45% |
14.78 |
17.48 |
days |
mean |
20 |
℃ |
hermaphrodite |
Two redundant homologues of the klotho gene exist in C. elegans and encode predicted proteins homologous to the glucosidase-like KL1 domain of mammalian Klotho. Knock-down of both klotho homologs by RNAi shortens lifespan. Klotho requires EGL-15 (FGFR) and EGL-17 to promote longevity |
Château et al. |
2010 |
20844315 |
|
Lifespan Observations Database (ID: 2839) |
164 |
OB_001012 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Dafachronic acid |
0 |
- |
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2, Z3 laser ablation at L1 larval stage |
|
decreased |
-15.48% |
13.1 |
15.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
When germline-deficient animals lacking somatic reproductive tissues are given dafachronic acid, their expression of DAF-12/NHR-dependent target genes is restored and their lifespan is increased. |
Yamawaki et al. |
2010 |
20824162 |
doi:10.1371/journal.pbio.1000468 |
Lifespan Observations Database (ID: 2334) |
165 |
OB_002845 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-15.54% |
14.02 |
16.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Suppressed neuronal cGMP level caused by GPA-3 activation leads to a significant increase (47.3%) in the mean lifespan of adult C. elegans through forkhead transcription factor family O (FOXO)-mediated signal. |
Hahm et al. |
2009 |
19489741 |
doi:10.1111/j.1474-9726.2009.00495.x |
Lifespan Observations Database (ID: 4134) |
166 |
OB_002125 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
rha-2 |
Caenorhabditis elegans |
176207 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-15.62% |
16.2 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 29% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3412) |
167 |
OB_002475 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m27 |
unknown |
unknown |
spe-26 |
Caenorhabditis elegans |
177929 |
unknown |
it118 |
unknown |
unknown |
|
|
|
decreased |
-15.66% |
16.7 |
19.8 |
days |
mean |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Fourth experiment. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3734) |
168 |
OB_001011 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2, Z3 laser ablation at L1 larval stage |
|
decreased |
-16.13% |
13 |
15.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
When germline-deficient animals lacking somatic reproductive tissues are given dafachronic acid, their expression of DAF-12/NHR-dependent target genes is restored and their lifespan is increased. |
Yamawaki et al. |
2010 |
20824162 |
doi:10.1371/journal.pbio.1000468 |
Lifespan Observations Database (ID: 2333) |
169 |
OB_002333 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-16.48% |
15.2 |
18.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA interference decreased lifespan by 16%. |
Berman et al. |
2006 |
16530050 |
doi:10.1016/j.cell.2006.01.039 |
Lifespan Observations Database (ID: 3606) |
170 |
OB_004268 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
|
|
decreased |
-16.49% |
16.2 |
19.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
The daf-16(mu86) null allele significantly shortened life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 965) |
171 |
OB_000846 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
non-null recessive |
mu86 |
unknown |
unknown |
|
|
|
decreased |
-16.67% |
20 |
24 |
days |
median |
20 |
℃ |
hermaphrodite |
Dietary restriction by bacterial deprivation increases the life span of wild type and daf-16 mutants, but fails to increase the life span of hsf-1 mutants. |
Steinkraus et al. |
2008 |
18331616 |
doi:10.1111/j.1474-9726.2008.00385.x |
Lifespan Observations Database (ID: 2127) |
172 |
OB_001577 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
rsks-1 |
Caenorhabditis elegans |
176554 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-16.67% |
16 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan 20% relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2915) |
173 |
OB_002124 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
ril-2 |
Caenorhabditis elegans |
179725 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-16.67% |
16 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 25% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3411) |
174 |
OB_002421 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-16.67% |
10 |
12 |
days |
max |
25 |
℃ |
hermaphrodite |
RNA knockdown decreased maximum lifespan approximately 16%. |
Boehm et al. |
2005 |
16373574 |
doi:10.1126/science.1115596 |
Lifespan Observations Database (ID: 3686) |
175 |
OB_002634 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
|
|
|
decreased |
-16.67% |
13.5 |
16.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
The mood stabilizer and anticonvulsant valproic acid (VA) extended C. elegans lifespan. |
Evason et al. |
2008 |
18248662 |
doi:10.1111/j.1474-9726.2008.00375.x |
Lifespan Observations Database (ID: 3928) |
176 |
OB_002023 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
wip-1 |
Caenorhabditis elegans |
175681 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-17.01% |
12.2 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3320) |
177 |
OB_002315 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-17.05% |
14.6 |
17.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knockdown results in 17% decreased lifespan. |
Oh et al. |
2005 |
15767565 |
doi:10.1073/pnas.0500749102 |
Lifespan Observations Database (ID: 3590) |
178 |
OB_002849 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-11 |
Caenorhabditis elegans |
179605 |
unknown |
m47 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-17.43% |
14.69 |
17.79 |
days |
mean |
20 |
℃ |
hermaphrodite |
Suppressed neuronal cGMP level caused by GPA-3 activation leads to a significant increase (47.3%) in the mean lifespan of adult C. elegans through forkhead transcription factor family O (FOXO)-mediated signal. |
Hahm et al. |
2009 |
19489741 |
doi:10.1111/j.1474-9726.2009.00495.x |
Lifespan Observations Database (ID: 4138) |
179 |
OB_002316 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
jnk-1 |
Caenorhabditis elegans |
177460 |
over-expression |
lpln1 |
unknown |
unknown |
|
|
|
decreased |
-17.61% |
14.5 |
17.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knockdown results in 17% decreased lifespan. |
Oh et al. |
2005 |
15767565 |
doi:10.1073/pnas.0500749102 |
Lifespan Observations Database (ID: 3591) |
180 |
OB_000960 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
unknown |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-17.65% |
14 |
17 |
|
median |
25 |
℃ |
hermaphrodite |
C08H9.1 is required for daf-2(e1370), but not wild-type, longevity at 25C. |
McColl et al. |
2010 |
20816092 |
doi:10.1016/j.cmet.2010.08.004 |
Lifespan Observations Database (ID: 2267) |
181 |
OB_001574 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
rps-22 |
Caenorhabditis elegans |
175338 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-18.23% |
15.7 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan 10% relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2912) |
182 |
OB_001588 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
let-363 |
Caenorhabditis elegans |
172167 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-18.23% |
15.7 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown extended lifespan 14% relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2925) |
183 |
OB_002959 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
|
|
decreased |
-18.32% |
10.7 |
13.1 |
days |
mean |
20 |
℃ |
hermaphrodite |
In Caenorhabditis elegans, functional ttx-3, sra-11, ceh-10, and ceh-23 genes are required for the functions of AIY interneuron. Compared to wild-type N2, mutations in ttx-3 and ceh-10 significantly decreased lifespan, whereas mutations in sra-11 and ceh-23 did not obviously influence nematode lifespan. Mutations in ttx-3 and ceh-10 were associated closely with lower pumping rates at adult day 8 and caused a more rapid accumulated intestinal autofluorescence than wild-type N2. Mutations in ceh-10 remarkably affected fertility and egg number in the uterus. The regulation of ttx-3 and ceh-10 on longevity was not temperature-dependent, and ttx-3, and ceh-10 mutants all formed very few dauers at 27 C. The shortened lifespan of the ttx-3 or ceh-10 mutants was completely or largely rescued by expression of TTX-3 or CEH-10 in AIY interneurons. Moreover, the long-lived phenotype of the daf-2 mutant could be suppressed by both the ttx-3 and the ceh-10 mutations. Furthermore, ablation of AIY interneurons shortened the longevity of wild-type and the daf-2 mutant. |
Shen et al. |
2010 |
21055415 |
doi:10.1016/j.mad.2010.10.005 |
Lifespan Observations Database (ID: 4279) |
184 |
OB_002734 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
|
|
decreased |
-18.50% |
14.1 |
17.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
Overexpression of DRR-2 has little effect on wild type life span but blunts life span extension from inhibition of TOR or from DR. |
Ching et al. |
2010 |
20456299 |
doi:10.1111/j.1474-9726.2010.00580.x |
Lifespan Observations Database (ID: 4029) |
185 |
OB_001203 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
- |
unknown |
unknown |
|
|
|
decreased |
-18.56% |
13.6 |
16.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Loss-of-function mutations decreased lifespan 18%. |
Lans et al. |
2007 |
17187771 |
doi:10.1016/j.ydbio.2006.11.028 |
Lifespan Observations Database (ID: 2528) |
186 |
OB_002555 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
tub-1 |
Caenorhabditis elegans |
174312 |
deletion / null |
nr2004 |
unknown |
unknown |
|
|
|
decreased |
-18.57% |
11.4 |
14 |
days |
mean |
25 |
℃ |
hermaphrodite |
Double mutation shortens lifespan approximately 20%. |
Mukhopadhyay et al. |
2005 |
16054097 |
doi:10.1016/j.cmet.2005.06.004 |
Lifespan Observations Database (ID: 3806) |
187 |
OB_002556 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
|
|
decreased |
-18.57% |
11.4 |
14 |
days |
mean |
25 |
℃ |
hermaphrodite |
Mutation shortens lifespan approximately 20%. |
Mukhopadhyay et al. |
2005 |
16054097 |
doi:10.1016/j.cmet.2005.06.004 |
Lifespan Observations Database (ID: 3807) |
188 |
OB_001096 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
daf-19 |
Caenorhabditis elegans |
174577 |
unknown |
m86 |
unknown |
unknown |
|
|
|
decreased |
-18.62% |
15.3 |
18.8 |
days |
mean |
20 |
℃ |
hermaphrodite |
Several (but not all) mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. Life span extension is generally partially or completely suppressed by mutation of daf-16. |
Apfeld et al. |
1999 |
10617200 |
doi:10.1038/45544 |
Lifespan Observations Database (ID: 2415) |
189 |
OB_001014 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2, Z3 laser ablation at L1 larval stage |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
decreased |
-18.71% |
12.6 |
15.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
When germline-deficient animals lacking somatic reproductive tissues are given dafachronic acid, their expression of DAF-12/NHR-dependent target genes is restored and their lifespan is increased. |
Yamawaki et al. |
2010 |
20824162 |
doi:10.1371/journal.pbio.1000468 |
Lifespan Observations Database (ID: 2336) |
190 |
OB_001584 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
iftb-1 |
Caenorhabditis elegans |
172584 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-18.75% |
15.6 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2921) |
191 |
OB_002542 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
|
|
decreased |
-19.05% |
17 |
21 |
days |
max |
25 |
℃ |
hermaphrodite |
Mutation shortened maximum lifespan 19%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3795) |
192 |
OB_002544 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
decreased |
-19.05% |
17 |
21 |
days |
max |
25 |
℃ |
hermaphrodite |
Double mutation shortened maximum lifespan 20%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3797) |
193 |
OB_002526 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
|
|
decreased |
-19.09% |
8.9 |
11 |
days |
mean |
25 |
℃ |
hermaphrodite |
Mutation shortens lifespan approximately 19%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3780) |
194 |
OB_001568 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
rps-15 |
Caenorhabditis elegans |
172693 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-19.27% |
15.5 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan 20% relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2907) |
195 |
OB_001590 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
let-363 |
Caenorhabditis elegans |
172167 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-19.27% |
15.5 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown extended lifespan 10% relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2927) |
196 |
OB_002120 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
pat-4 |
Caenorhabditis elegans |
175175 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-19.27% |
15.5 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 23% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3408) |
197 |
OB_002330 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-19.29% |
15.9 |
19.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA interference decreased lifespan by approximately 20%. |
Berman et al. |
2006 |
16530050 |
doi:10.1016/j.cell.2006.01.039 |
Lifespan Observations Database (ID: 3603) |
198 |
OB_002850 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-19.39% |
14.34 |
17.79 |
days |
mean |
20 |
℃ |
hermaphrodite |
Suppressed neuronal cGMP level caused by GPA-3 activation leads to a significant increase (47.3%) in the mean lifespan of adult C. elegans through forkhead transcription factor family O (FOXO)-mediated signal. |
Hahm et al. |
2009 |
19489741 |
doi:10.1111/j.1474-9726.2009.00495.x |
Lifespan Observations Database (ID: 4139) |
199 |
OB_002440 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
ogt-1 |
Caenorhabditis elegans |
176000 |
deletion / null |
ok1474 |
unknown |
unknown |
|
|
|
decreased |
-19.50% |
12.8 |
15.9 |
|
median |
20 |
℃ |
hermaphrodite |
Median adult lifespan is increased in an oga-1 deletion strain while median adult life span is decreased upon ogt-1 deletion. The O-GlcNAc-mediated effect on nematode lifespan is dependent on the FoxO transcription factor DAF-16. |
Rahman et al. |
2010 |
20952811 |
|
Lifespan Observations Database (ID: 3702) |
200 |
OB_002631 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Valproic acid |
6 |
mM |
|
|
decreased |
-19.75% |
13 |
16.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
The mood stabilizer and anticonvulsant valproic acid (VA) extended C. elegans lifespan. |
Evason et al. |
2008 |
18248662 |
doi:10.1111/j.1474-9726.2008.00375.x |
Lifespan Observations Database (ID: 3925) |
201 |
OB_001587 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
let-363 |
Caenorhabditis elegans |
172167 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-19.79% |
15.4 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown extended lifespan 19% relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2924) |
202 |
OB_002105 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
gpi-1 |
Caenorhabditis elegans |
173227 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-19.79% |
15.4 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan of daf-16 mutants. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3395) |
203 |
OB_001234 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
mu150 |
unknown |
unknown |
|
|
|
decreased |
-19.81% |
16.6 |
20.7 |
days |
mean |
|
|
hermaphrodite |
RNA interference in adulthood shortened the extended lifespan of daf-2(mu150) mutants. |
Ghazi et al. |
2007 |
17392428 |
doi:10.1073/pnas.0700638104 |
Lifespan Observations Database (ID: 2564) |
204 |
OB_002537 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
|
|
decreased |
-20.00% |
20 |
25 |
days |
max |
20 |
℃ |
hermaphrodite |
Mutation shortened lifespan approximately 20%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3790) |
205 |
OB_002539 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
decreased |
-20.00% |
20 |
25 |
days |
max |
20 |
℃ |
hermaphrodite |
Double mutation shortened maximum lifespan 20%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3792) |
206 |
OB_003440 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
sea-2 |
Caenorhabditis elegans |
173738 |
loss of function |
- |
unknown |
unknown |
|
|
|
decreased |
-20.00% |
16 |
20 |
|
|
20 |
℃ |
|
Lifespan of daf-16;sea-2;daf-2(e1370) triple mutant was approximately 20% shorter than control. |
Huang et al. |
2011 |
21471153 |
doi:10.1242/dev.057109 |
Lifespan Observations Database (ID: 4867) |
207 |
OB_003446 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
sea-2 |
Caenorhabditis elegans |
173738 |
loss of function |
bp283 |
unknown |
unknown |
|
|
|
decreased |
-20.00% |
20 |
25 |
days |
max |
20 |
℃ |
|
Maximum lifespan of daf-16;sea-2;daf-2 triple mutant was approximately 20% shorter than control. |
Huang et al. |
2011 |
21471153 |
doi:10.1242/dev.057109 |
Lifespan Observations Database (ID: 4872) |
208 |
OB_000318 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mgDf50 |
unknown |
unknown |
|
|
|
decreased |
-20.22% |
14.6 |
18.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
Transgenic overexpression of sir-2.1 from an extrachromosomal or integrated multicopy array extends life span. Other phenotypes: Life span extension is suppressed by a mutation in daf-16 and does not synergize with daf-2. Overexpression of sir-2.1 synergizes with the TGF-beta mutations daf-4 and daf-1 for dauer formation. |
Tissenbaum et al. |
2001 |
11242085 |
doi:10.1038/35065638 |
Lifespan Observations Database (ID: 146) |
209 |
OB_002118 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
drr-1 |
Caenorhabditis elegans |
174994 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-20.31% |
15.3 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 18% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3406) |
210 |
OB_001894 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-20.41% |
11.7 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3204) |
211 |
OB_002847 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
gpa-3 |
Caenorhabditis elegans |
179319 |
gain of function |
QL |
unknown |
unknown |
|
|
|
decreased |
-21.08% |
13.1 |
16.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Suppressed neuronal cGMP level caused by GPA-3 activation leads to a significant increase (47.3%) in the mean lifespan of adult C. elegans through forkhead transcription factor family O (FOXO)-mediated signal. |
Hahm et al. |
2009 |
19489741 |
doi:10.1111/j.1474-9726.2009.00495.x |
Lifespan Observations Database (ID: 4136) |
212 |
OB_002496 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
decreased |
-21.21% |
26 |
33 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). First experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3753) |
213 |
OB_001022 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mgDf50 |
unknown |
unknown |
sir-2.1 |
Caenorhabditis elegans |
177924 |
over-expression |
geEx3 |
unknown |
unknown |
|
|
|
decreased |
-21.31% |
14.4 |
18.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
Transgenic overexpression of sir-2.1 from an extrachromosomal or integrated multicopy array extends life span. Other phenotypes: Life span extension is suppressed by a mutation in daf-16 and does not synergize with daf-2. Overexpression of sir-2.1 synergizes with the TGF-beta mutations daf-4 and daf-1 for dauer formation. |
Tissenbaum et al. |
2001 |
11242085 |
doi:10.1038/35065638 |
Lifespan Observations Database (ID: 2343) |
214 |
OB_003783 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Heat stress |
35 degrees |
|
decreased |
-21.43% |
11 |
14 |
|
mean |
35 |
℃ |
|
RNAi knockdown of daf-16 decreased lifespan of N2 worms by 21% under heat stress. |
Maman et al. |
2013 |
23554491 |
doi:10.1523/JNEUROSCI.4023-12.2013 |
Lifespan Observations Database (ID: 5363) |
215 |
OB_001570 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
rps-15 |
Caenorhabditis elegans |
172693 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-21.88% |
15 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan 17% relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2909) |
216 |
OB_004269 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-21.94% |
15.3 |
19.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Daf-16(RNAi) significantly shortened life span of N2 animals. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 966) |
217 |
OB_004271 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-22.18% |
20 |
25.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Daf-16(RNAi) shortened the life span of N2 animals. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 968) |
218 |
OB_002128 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
nuo-5 |
Caenorhabditis elegans |
178735 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-22.40% |
14.9 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 17% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3415) |
219 |
OB_001020 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mgDf50 |
unknown |
unknown |
sir-2.1 |
Caenorhabditis elegans |
177924 |
over-expression |
geEx1 |
unknown |
unknown |
|
|
|
decreased |
-22.40% |
14.2 |
18.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
Transgenic overexpression of sir-2.1 from an extrachromosomal or integrated multicopy array extends life span. Other phenotypes: Life span extension is suppressed by a mutation in daf-16 and does not synergize with daf-2. Overexpression of sir-2.1 synergizes with the TGF-beta mutations daf-4 and daf-1 for dauer formation. |
Tissenbaum et al. |
2001 |
11242085 |
doi:10.1038/35065638 |
Lifespan Observations Database (ID: 2341) |
220 |
OB_001505 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
loss of function |
hx546 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-22.84% |
17.9 |
23.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA knockdown of daf-16 in age-1 mutant decreased lifespan by 44% relative to age-1 mutant lifespan. |
Morley et al. |
2004 |
14668486 |
doi:10.1091/mbc.E03-07-0532 |
Lifespan Observations Database (ID: 2850) |
221 |
OB_001094 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
|
|
decreased |
-22.87% |
14.5 |
18.8 |
days |
mean |
20 |
℃ |
hermaphrodite |
Several (but not all) mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. Life span extension is generally partially or completely suppressed by mutation of daf-16. |
Apfeld et al. |
1999 |
10617200 |
doi:10.1038/45544 |
Lifespan Observations Database (ID: 2413) |
222 |
OB_001580 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
iftb-1 |
Caenorhabditis elegans |
172584 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-22.92% |
14.8 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2918) |
223 |
OB_002101 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
ttr-1 |
Caenorhabditis elegans |
186958 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-23.44% |
14.7 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan of daf-16 mutants. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3391) |
224 |
OB_002638 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Valproic acid |
3 |
mM |
|
|
decreased |
-23.46% |
12.4 |
16.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
The mood stabilizer and anticonvulsant valproic acid (VA) extended C. elegans lifespan. |
Evason et al. |
2008 |
18248662 |
doi:10.1111/j.1474-9726.2008.00375.x |
Lifespan Observations Database (ID: 3931) |
225 |
OB_001021 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mgDf50 |
unknown |
unknown |
sir-2.1 |
Caenorhabditis elegans |
177924 |
over-expression |
geEx2 |
unknown |
unknown |
|
|
|
decreased |
-23.50% |
14 |
18.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
Transgenic overexpression of sir-2.1 from an extrachromosomal or integrated multicopy array extends life span. Other phenotypes: Life span extension is suppressed by a mutation in daf-16 and does not synergize with daf-2. Overexpression of sir-2.1 synergizes with the TGF-beta mutations daf-4 and daf-1 for dauer formation. |
Tissenbaum et al. |
2001 |
11242085 |
doi:10.1038/35065638 |
Lifespan Observations Database (ID: 2342) |
226 |
OB_002520 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
|
|
|
decreased |
-23.53% |
10.4 |
13.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutation shortens lifespan approximately 25%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3775) |
227 |
OB_002340 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
glp-1 |
Caenorhabditis elegans |
176286 |
loss of function |
e2141ts |
unknown |
unknown |
|
|
|
decreased |
-23.86% |
15 |
19.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Double mutant lifespan was decreased by 51% relative to glp-1(e214ts) mutant lifespan. |
Berman et al. |
2006 |
16530050 |
doi:10.1016/j.cell.2006.01.039 |
Lifespan Observations Database (ID: 3612) |
228 |
OB_002112 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
ddl-1 |
Caenorhabditis elegans |
173954 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-23.96% |
14.6 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan of daf-16 mutants. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3400) |
229 |
OB_002119 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
drr-2 |
Caenorhabditis elegans |
259546 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-23.96% |
14.6 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 16% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3407) |
230 |
OB_002121 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
pat-6 |
Caenorhabditis elegans |
176848 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-23.96% |
14.6 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 16% relative to daf-16 mutant lifespan alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3409) |
231 |
OB_003450 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
|
|
|
decreased |
-24.00% |
19 |
25 |
days |
max |
20 |
℃ |
|
Maximum lifespan of daf-16 mutant was approximately 24% shorter than control. |
Huang et al. |
2011 |
21471153 |
doi:10.1242/dev.057109 |
Lifespan Observations Database (ID: 4876) |
232 |
OB_001468 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
unknown |
e1370 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trehalose |
5 |
mM |
|
|
decreased |
-24.16% |
20.4 |
26.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Treatment of Caenorhabditis elegans with trehalose starting from the young-adult stage extended the mean life span by over 30% without any obvious side effects. Trehalose extended life span more effectively on UV-killed E. coli than on live E. coli. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation. The life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants. RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span. |
Honda et al. |
2010 |
20477758 |
doi:10.1111/j.1474-9726.2010.00582.x |
Lifespan Observations Database (ID: 2789) |
233 |
OB_002482 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
age-1 |
Caenorhabditis elegans |
174762 |
unknown |
hx546 |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
unknown |
m26 |
unknown |
unknown |
|
|
|
decreased |
-24.32% |
28 |
37 |
days |
max |
20 |
℃ |
hermaphrodite |
Increased longevity of the Age mutants was suppressed by daf-l6(m26). Second experiment. Maximum life span is from duplicated plates. |
Murakami et al. |
1996 |
8807294 |
|
Lifespan Observations Database (ID: 3740) |
234 |
OB_001013 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Dafachronic acid |
0 |
- |
|
Other Ageing Factor Name |
Additional Information |
Germ cell ablation |
Z2, Z3 laser ablation at L1 larval stage |
Somatic gonad ablation |
Z1, Z4 laser ablation at L1 larval stage |
|
decreased |
-24.52% |
11.7 |
15.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
When germline-deficient animals lacking somatic reproductive tissues are given dafachronic acid, their expression of DAF-12/NHR-dependent target genes is restored and their lifespan is increased. |
Yamawaki et al. |
2010 |
20824162 |
doi:10.1371/journal.pbio.1000468 |
Lifespan Observations Database (ID: 2335) |
235 |
OB_002978 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf50 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Catechin |
200 |
micromolar |
|
|
decreased |
-24.84% |
12.71 |
16.91 |
days |
mean |
20 |
℃ |
hermaphrodite |
The flavanol catechin extended life span in C. elegans. |
Saul et al. |
2009 |
19501612 |
doi:10.1016/j.mad.2009.05.005 |
Lifespan Observations Database (ID: 4313) |
236 |
OB_001575 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
rpl-4 |
Caenorhabditis elegans |
172074 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-25.00% |
14.4 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan 23% relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2913) |
237 |
OB_002100 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-25.00% |
14.4 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown extended lifespan of daf-16 mutants by 9% relative to daf-16 lifespan. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3390) |
238 |
OB_002104 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
maoc-1 |
Caenorhabditis elegans |
174181 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-25.00% |
14.4 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan of daf-16 mutants. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3394) |
239 |
OB_002113 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
ddl-2 |
Caenorhabditis elegans |
190025 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-25.00% |
14.4 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan of daf-16 mutants. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3401) |
240 |
OB_002114 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
ddl-2 |
Caenorhabditis elegans |
190025 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-25.00% |
14.4 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan of daf-16 mutants. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3402) |
241 |
OB_000319 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mgDf50 |
unknown |
unknown |
sir-2.1 |
Caenorhabditis elegans |
177924 |
over-expression |
geIn3 |
unknown |
unknown |
|
|
|
decreased |
-25.14% |
13.7 |
18.3 |
days |
mean |
|
|
hermaphrodite |
< Transgenic overexpression of sir-2.1 from an extrachromosomal or integrated multicopy array extends life span. Other phenotypes: Life span extension is suppressed by a mutation in daf-16 and does not synergize with daf-2. Overexpression of sir-2.1 synergizes with the TGF-beta mutations daf-4 and daf-1 for dauer formation. |
Tissenbaum et al. |
2001 |
11242085 |
doi:10.1038/35065638 |
Lifespan Observations Database (ID: 147) |
242 |
OB_002321 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
glp-1 |
Caenorhabditis elegans |
176286 |
loss of function |
e2141ts |
unknown |
unknown |
|
|
|
decreased |
-25.38% |
14.7 |
19.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA interference suppressed glp-1 life-extension by 40% relative to mutant lifespan. |
Berman et al. |
2006 |
16530050 |
doi:10.1016/j.cell.2006.01.039 |
Lifespan Observations Database (ID: 3596) |
243 |
OB_001579 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
iftb-1 |
Caenorhabditis elegans |
172584 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-25.52% |
14.3 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2917) |
244 |
OB_002108 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
sinh-1 |
Caenorhabditis elegans |
190339 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-25.52% |
14.3 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan of daf-16 mutants. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3398) |
245 |
OB_002115 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
ddl-3 |
Caenorhabditis elegans |
175087 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-25.52% |
14.3 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan of daf-16 mutants. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3403) |
246 |
OB_002635 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Valproic acid |
0.6 |
mM |
|
|
decreased |
-25.93% |
12 |
16.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
The mood stabilizer and anticonvulsant valproic acid (VA) extended C. elegans lifespan. |
Evason et al. |
2008 |
18248662 |
doi:10.1111/j.1474-9726.2008.00375.x |
Lifespan Observations Database (ID: 3929) |
247 |
OB_001573 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
rps-22 |
Caenorhabditis elegans |
175338 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-26.04% |
14.2 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan 11% relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2911) |
248 |
OB_002020 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
unc-60 |
Caenorhabditis elegans |
178640 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-26.53% |
10.8 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3318) |
249 |
OB_002021 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C25H3.6 |
Caenorhabditis elegans |
173960 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-26.53% |
10.8 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3319) |
250 |
OB_001576 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
rpl-19 |
Caenorhabditis elegans |
172201 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-26.56% |
14.1 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan 21% relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2914) |
251 |
OB_003441 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
- |
unknown |
unknown |
|
|
|
decreased |
-26.59% |
12.7 |
17.3 |
days |
mean |
20 |
℃ |
|
Mean lifespan of daf-16 mutant was approximately 27% shorter than control. |
Huang et al. |
2011 |
21471153 |
doi:10.1242/dev.057109 |
Lifespan Observations Database (ID: 4868) |
252 |
OB_001567 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
rps-15 |
Caenorhabditis elegans |
172693 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-27.08% |
14 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan 20% relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2906) |
253 |
OB_002103 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
maoc-1 |
Caenorhabditis elegans |
174181 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-27.08% |
14 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan of daf-16 mutants. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3393) |
254 |
OB_002106 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
gpi-1 |
Caenorhabditis elegans |
173227 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-27.08% |
14 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan of daf-16 mutants. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3396) |
255 |
OB_001502 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-27.16% |
16.9 |
23.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA knockdown decreased lifespan by 27%. |
Morley et al. |
2004 |
14668486 |
doi:10.1091/mbc.E03-07-0532 |
Lifespan Observations Database (ID: 2848) |
256 |
OB_002637 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Valproic acid |
3 |
mM |
|
|
decreased |
-27.16% |
11.8 |
16.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
The mood stabilizer and anticonvulsant valproic acid (VA) extended C. elegans lifespan. |
Evason et al. |
2008 |
18248662 |
doi:10.1111/j.1474-9726.2008.00375.x |
Lifespan Observations Database (ID: 3930) |
257 |
OB_001470 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Trehalose |
5 |
mM |
|
|
decreased |
-27.51% |
19.5 |
26.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Treatment of Caenorhabditis elegans with trehalose starting from the young-adult stage extended the mean life span by over 30% without any obvious side effects. Trehalose extended life span more effectively on UV-killed E. coli than on live E. coli. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation. The life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants. RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span. |
Honda et al. |
2010 |
20477758 |
doi:10.1111/j.1474-9726.2010.00582.x |
Lifespan Observations Database (ID: 2790) |
258 |
OB_002107 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
sinh-1 |
Caenorhabditis elegans |
190339 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-27.60% |
13.9 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan of daf-16 mutants. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3397) |
259 |
OB_004272 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
non-null recessive |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-27.63% |
18.6 |
25.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Daf-16(RNAi) suppressed the life span extension associated with the daf-2(e1370) allele. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 969) |
260 |
OB_002017 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
bet-1 |
Caenorhabditis elegans |
172054 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-27.89% |
10.6 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3315) |
261 |
OB_002018 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
top-1 |
Caenorhabditis elegans |
266847 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-27.89% |
10.6 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3316) |
262 |
OB_002019 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
R12B2.6 |
Caenorhabditis elegans |
187837 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-27.89% |
10.6 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3317) |
263 |
OB_001591 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-27.91% |
12.4 |
17.2 |
days |
mean |
25 |
℃ |
hermaphrodite |
RNA knockdown throughout whole life of N2 decreased lifespan 27%. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2928) |
264 |
OB_003449 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
sea-2 |
Caenorhabditis elegans |
173738 |
loss of function |
bp283 |
unknown |
unknown |
|
|
|
decreased |
-28.00% |
18 |
25 |
days |
max |
20 |
℃ |
|
Maximum lifespan of daf-16;sea-2 mutant was approximately 28% shorter than control. |
Huang et al. |
2011 |
21471153 |
doi:10.1242/dev.057109 |
Lifespan Observations Database (ID: 4875) |
265 |
OB_002908 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf50 |
unknown |
unknown |
|
|
|
decreased |
-28.93% |
11.3 |
15.9 |
days |
mean |
30 |
℃ |
hermaphrodite |
cep-1 is required to extend longevity in response to mild suppression of several bioenergetically relevant mitochondrial proteins, including frataxin the protein defective in patients with Friedreichs Ataxia. |
Ventura et al. |
2009 |
19416129 |
doi:10.1111/j.1474-9726.2009.00482.x |
Lifespan Observations Database (ID: 4228) |
266 |
OB_002327 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
glp-1 |
Caenorhabditis elegans |
176286 |
loss of function |
e2141ts |
unknown |
unknown |
|
|
|
decreased |
-29.12% |
12.9 |
18.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA interference suppressed glp-1 life-extension by 35% relative to mutant lifespan. |
Berman et al. |
2006 |
16530050 |
doi:10.1016/j.cell.2006.01.039 |
Lifespan Observations Database (ID: 3600) |
267 |
OB_001583 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
iftb-1 |
Caenorhabditis elegans |
172584 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-29.17% |
13.6 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2920) |
268 |
OB_002102 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
ttr-1 |
Caenorhabditis elegans |
186958 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-29.17% |
13.6 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan of daf-16 mutants. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3392) |
269 |
OB_002016 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
F52C6.2 |
Caenorhabditis elegans |
173558 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-29.25% |
10.4 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3314) |
270 |
OB_002013 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
D2085.5 |
Caenorhabditis elegans |
3564922 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-29.93% |
10.3 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3311) |
271 |
OB_002014 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C29F9.2 |
Caenorhabditis elegans |
175179 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-29.93% |
10.3 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3312) |
272 |
OB_002015 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C29F9.1 |
Caenorhabditis elegans |
175180 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-29.93% |
10.3 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3313) |
273 |
OB_002733 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Overfeeding |
1 x 10^12 cells/mL. A 10-fold increase from control. UV-killed E. coli food source. |
|
decreased |
-30.06% |
12.1 |
17.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
Overexpression of DRR-2 has little effect on wild type life span but blunts life span extension from inhibition of TOR or from DR. |
Ching et al. |
2010 |
20456299 |
doi:10.1111/j.1474-9726.2010.00580.x |
Lifespan Observations Database (ID: 4028) |
274 |
OB_001477 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
unknown |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-30.12% |
17.4 |
24.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Treatment of Caenorhabditis elegans with trehalose starting from the young-adult stage extended the mean life span by over 30% without any obvious side effects. Trehalose extended life span more effectively on UV-killed E. coli than on live E. coli. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation. The life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants. RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span. |
Honda et al. |
2010 |
20477758 |
doi:10.1111/j.1474-9726.2010.00582.x |
Lifespan Observations Database (ID: 2799) |
275 |
OB_001480 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
unknown |
e1370 |
unknown |
unknown |
tps-1 |
Caenorhabditis elegans |
181778 |
RNAi knockdown |
- |
unknown |
unknown |
tps-2 |
Caenorhabditis elegans |
3565050 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-30.12% |
17.4 |
24.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Treatment of Caenorhabditis elegans with trehalose starting from the young-adult stage extended the mean life span by over 30% without any obvious side effects. Trehalose extended life span more effectively on UV-killed E. coli than on live E. coli. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation. The life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants. RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span. |
Honda et al. |
2010 |
20477758 |
doi:10.1111/j.1474-9726.2010.00582.x |
Lifespan Observations Database (ID: 2800) |
276 |
OB_001592 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
ife-2 |
Caenorhabditis elegans |
180393 |
loss of function |
ok306 |
unknown |
unknown |
|
|
|
decreased |
-30.23% |
12 |
17.2 |
days |
mean |
25 |
℃ |
hermaphrodite |
RNA knockdown throughout whole life of eIF4E/ife-2(ok306) decreased lifespan 44% relative to ife-2 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2929) |
277 |
OB_002979 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf50 |
unknown |
unknown |
|
|
|
decreased |
-30.28% |
11.79 |
16.91 |
days |
mean |
20 |
℃ |
hermaphrodite |
The flavanol catechin extended life span in C. elegans. |
Saul et al. |
2009 |
19501612 |
doi:10.1016/j.mad.2009.05.005 |
Lifespan Observations Database (ID: 4314) |
278 |
OB_003618 |
Caenorhabditis elegans |
cdc-48.1(tm544); atx-3(gk193) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-30.43% |
16 |
23 |
days |
mean |
20 |
℃ |
|
RNAi depletion of DAF-16 suppressed the extended lifespan of cdc-48.1(tm544); atx-3(gk193) worms completely and similarly reduced lifespan of N2 wild-type worms. |
Kuhlbrodt et al. |
2011 |
21317884 |
doi:10.1038/ncb2200 |
Lifespan Observations Database (ID: 5058) |
279 |
OB_003410 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cdc-25.1 |
Caenorhabditis elegans |
172353 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
decreased |
-30.55% |
69.8 |
100.5 |
|
mean |
25 |
℃ |
|
RNAi knockdown of cdc-25.1 Glp and daf-16 shortened lifespan approximately 30% in N2 animals. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4836) |
280 |
OB_002010 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
F40F12.7 |
Caenorhabditis elegans |
176402 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-30.61% |
10.2 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3309) |
281 |
OB_002012 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
K11D12.9 |
Caenorhabditis elegans |
178892 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-30.61% |
10.2 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3310) |
282 |
OB_001586 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
iftb-1 |
Caenorhabditis elegans |
172584 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-31.25% |
13.2 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown shortened lifespan 8% relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2923) |
283 |
OB_001907 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-31.29% |
10.1 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3216) |
284 |
OB_002006 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
Y42G9A.4 |
Caenorhabditis elegans |
175863 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-31.29% |
10.1 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3305) |
285 |
OB_002007 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
Y54G2A.31 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-31.29% |
10.1 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3306) |
286 |
OB_002008 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
D1069.3 |
Caenorhabditis elegans |
173425 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-31.29% |
10.1 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3307) |
287 |
OB_002009 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
mcm-2 |
Caenorhabditis elegans |
174841 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-31.29% |
10.1 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3308) |
288 |
OB_001467 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
unknown |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-31.60% |
18.4 |
26.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Treatment of Caenorhabditis elegans with trehalose starting from the young-adult stage extended the mean life span by over 30% without any obvious side effects. Trehalose extended life span more effectively on UV-killed E. coli than on live E. coli. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation. The life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants. RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span. |
Honda et al. |
2010 |
20477758 |
doi:10.1111/j.1474-9726.2010.00582.x |
Lifespan Observations Database (ID: 2788) |
289 |
OB_002522 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
decreased |
-31.62% |
9.3 |
13.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Double mutation shortens lifespan approximately 32%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3777) |
290 |
OB_003786 |
Caenorhabditis elegans |
CF512 (fer-15(b26)II; fem-1(hc17)IV) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Heat stress |
35 degrees |
|
decreased |
-31.82% |
15 |
22 |
|
mean |
35 |
℃ |
|
RNAi knockdown of daf-16 decreased lifespan of CF512 (fer-15(b26)II; fem-1(hc17)IV) worms by approximately 32% under heat stress. |
Maman et al. |
2013 |
23554491 |
doi:10.1523/JNEUROSCI.4023-12.2013 |
Lifespan Observations Database (ID: 5366) |
291 |
OB_002003 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
his-71 |
Caenorhabditis elegans |
181057 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-31.97% |
10 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3302) |
292 |
OB_002004 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-31.97% |
10 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3303) |
293 |
OB_002005 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
baf-1 |
Caenorhabditis elegans |
176330 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-31.97% |
10 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3304) |
294 |
OB_000885 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
non-null semi-dominant |
m26 |
unknown |
unknown |
daf-28 |
Caenorhabditis elegans |
191014 |
non-null semi-dominant |
sa191 |
unknown |
unknown |
|
|
|
decreased |
-32.37% |
14 |
20.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Double mutant decreases lifespan approximately 32%. |
Malone et al. |
1996 |
8807293 |
|
Lifespan Observations Database (ID: 2190) |
295 |
OB_002002 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
alg-2 |
Caenorhabditis elegans |
173468 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-32.65% |
9.9 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3301) |
296 |
OB_002528 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
pept-1 |
Caenorhabditis elegans |
180919 |
deletion / null |
lg601 |
unknown |
unknown |
|
|
|
decreased |
-32.73% |
7.4 |
11 |
days |
mean |
25 |
℃ |
hermaphrodite |
Double mutation shortens lifespan 33%. |
Meissner et al. |
2004 |
15155758 |
doi:10.1074/jbc.M403415200 |
Lifespan Observations Database (ID: 3782) |
297 |
OB_001585 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
iftb-1 |
Caenorhabditis elegans |
172584 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-33.33% |
12.8 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2922) |
298 |
OB_001996 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
F39H11.2 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-33.33% |
9.8 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3297) |
299 |
OB_001997 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C31H2.1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-33.33% |
9.8 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3298) |
300 |
OB_001998 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
ptr-23 |
Caenorhabditis elegans |
173362 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-33.33% |
9.8 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3299) |
301 |
OB_002001 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cit-1.2 |
Caenorhabditis elegans |
176126 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-33.33% |
9.8 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3300) |
302 |
OB_001994 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
mdh-1 |
Caenorhabditis elegans |
175936 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-34.01% |
9.7 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3295) |
303 |
OB_001995 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
BE10.2 |
Caenorhabditis elegans |
176695 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-34.01% |
9.7 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3296) |
304 |
OB_002109 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
ddl-1 |
Caenorhabditis elegans |
173954 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-34.38% |
12.6 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan of daf-16 mutants. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3399) |
305 |
OB_001993 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
vps-33.1 |
Caenorhabditis elegans |
176221 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-34.69% |
9.6 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3294) |
306 |
OB_001471 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
|
|
|
decreased |
-34.94% |
17.5 |
26.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Treatment of Caenorhabditis elegans with trehalose starting from the young-adult stage extended the mean life span by over 30% without any obvious side effects. Trehalose extended life span more effectively on UV-killed E. coli than on live E. coli. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation. The life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants. RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span. |
Honda et al. |
2010 |
20477758 |
doi:10.1111/j.1474-9726.2010.00582.x |
Lifespan Observations Database (ID: 2791) |
307 |
OB_001989 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cua-1 |
Caenorhabditis elegans |
176770 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-35.37% |
9.5 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3290) |
308 |
OB_001990 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C14A4.9 |
Caenorhabditis elegans |
174637 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-35.37% |
9.5 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3291) |
309 |
OB_001991 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-35.37% |
9.5 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3292) |
310 |
OB_001992 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
sbds-1 |
Caenorhabditis elegans |
175218 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-35.37% |
9.5 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3293) |
311 |
OB_002116 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
(mu86)I |
unknown |
unknown |
ddl-3 |
Caenorhabditis elegans |
175087 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-35.42% |
12.4 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown decreased lifespan of daf-16 mutants by 10% relative to daf-16 mutant alone. |
Hansen et al. |
2005 |
16103914 |
doi:10.1371/journal.pgen.0010017 |
Lifespan Observations Database (ID: 3404) |
312 |
OB_003407 |
Caenorhabditis elegans |
glp-4(bn2) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
decreased |
-35.80% |
46.8 |
72.9 |
|
mean |
25 |
℃ |
|
Knock-down of daf-16 by RNA interference (RNAi) in glp-4(bn2) animals rendered these animals significantly more susceptible to PA14. Lifespan was approximately 34% shorter than control. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4833) |
313 |
OB_001581 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
iftb-1 |
Caenorhabditis elegans |
172584 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-35.94% |
12.3 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown did not have a significant effect on lifespan relative to daf-16 mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2919) |
314 |
OB_001985 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
sac-1 |
Caenorhabditis elegans |
172778 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-36.05% |
9.4 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3287) |
315 |
OB_001986 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
smk-1 |
Caenorhabditis elegans |
179243 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-36.05% |
9.4 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3288) |
316 |
OB_001987 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
gdi-1 |
Caenorhabditis elegans |
178402 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-36.05% |
9.4 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3289) |
317 |
OB_001979 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
elo-5 |
Caenorhabditis elegans |
177320 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-36.73% |
9.3 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3281) |
318 |
OB_001980 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
let-653 |
Caenorhabditis elegans |
178120 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-36.73% |
9.3 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3282) |
319 |
OB_001981 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
wwp-1 |
Caenorhabditis elegans |
171647 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-36.73% |
9.3 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3283) |
320 |
OB_001982 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
mag-1 |
Caenorhabditis elegans |
173073 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-36.73% |
9.3 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3284) |
321 |
OB_001983 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
T22B11.2 |
Caenorhabditis elegans |
188726 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-36.73% |
9.3 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3285) |
322 |
OB_001984 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
F28D1.9 |
Caenorhabditis elegans |
178190 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-36.73% |
9.3 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3286) |
323 |
OB_001510 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mgDf50 |
unknown |
unknown |
hsf-1 |
Caenorhabditis elegans |
173078 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-37.04% |
8.5 |
13.5 |
days |
mean |
25 |
℃ |
hermaphrodite |
RNA knockdown of hsf-1 of daf-16 mutan had no significant effect relative to daf-16 mutant lifespan. |
Morley et al. |
2004 |
14668486 |
doi:10.1091/mbc.E03-07-0532 |
Lifespan Observations Database (ID: 2855) |
324 |
OB_001482 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
|
|
|
decreased |
-37.35% |
15.6 |
24.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Treatment of Caenorhabditis elegans with trehalose starting from the young-adult stage extended the mean life span by over 30% without any obvious side effects. Trehalose extended life span more effectively on UV-killed E. coli than on live E. coli. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation. The life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants. RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span. |
Honda et al. |
2010 |
20477758 |
doi:10.1111/j.1474-9726.2010.00582.x |
Lifespan Observations Database (ID: 2802) |
325 |
OB_001974 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
hpk-1 |
Caenorhabditis elegans |
180695 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-37.41% |
9.2 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3277) |
326 |
OB_001975 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
Y55F3AM.3 |
Caenorhabditis elegans |
176922 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-37.41% |
9.2 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3278) |
327 |
OB_001976 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
Y57G11C.13 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-37.41% |
9.2 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3279) |
328 |
OB_001978 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
Y61A9LA.5 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-37.41% |
9.2 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3280) |
329 |
OB_003782 |
Caenorhabditis elegans |
daf-2(e1370) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-37.97% |
26.24 |
42.3 |
days |
mean |
20 |
℃ |
|
RNAi knockdown of daf-16 decreased lifespan of daf-2(e1370) worms by 38%. |
Maman et al. |
2013 |
23554491 |
doi:10.1523/JNEUROSCI.4023-12.2013 |
Lifespan Observations Database (ID: 5362) |
330 |
OB_001970 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
ntl-3 |
Caenorhabditis elegans |
176614 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-38.10% |
9.1 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3273) |
331 |
OB_001971 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
H27M09.1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-38.10% |
9.1 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3274) |
332 |
OB_001972 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
M57.2 |
Caenorhabditis elegans |
177113 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-38.10% |
9.1 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3275) |
333 |
OB_001973 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
vps-16 |
Caenorhabditis elegans |
175913 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-38.10% |
9.1 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3276) |
334 |
OB_001481 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
tps-1 |
Caenorhabditis elegans |
181778 |
RNAi knockdown |
- |
unknown |
unknown |
tps-2 |
Caenorhabditis elegans |
3565050 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-39.36% |
15.1 |
24.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Treatment of Caenorhabditis elegans with trehalose starting from the young-adult stage extended the mean life span by over 30% without any obvious side effects. Trehalose extended life span more effectively on UV-killed E. coli than on live E. coli. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation. The life span-extending effect of trehalose was abolished in long-lived insulin/IGF-1-like receptor (daf-2) mutants. RNA interference-mediated inactivation of the trehalose-biosynthesis genes trehalose-6-phosphate synthase-1 (tps-1) and tps-2, which are known to be up-regulated in daf-2 mutants, decreased the daf-2 life span. |
Honda et al. |
2010 |
20477758 |
doi:10.1111/j.1474-9726.2010.00582.x |
Lifespan Observations Database (ID: 2801) |
335 |
OB_001965 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
T14G10.1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-39.46% |
8.9 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3269) |
336 |
OB_001967 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C27F2.5 |
Caenorhabditis elegans |
175672 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-39.46% |
8.9 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3270) |
337 |
OB_001968 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
vps-36 |
Caenorhabditis elegans |
179520 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-39.46% |
8.9 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3271) |
338 |
OB_001969 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
lsm-7 |
Caenorhabditis elegans |
177988 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-39.46% |
8.9 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3272) |
339 |
OB_001964 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ain-1 |
Caenorhabditis elegans |
181719 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-40.14% |
8.8 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3268) |
340 |
OB_002250 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
25 |
mM |
|
|
decreased |
-40.41% |
11.5 |
19.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
Growing mutant worms on Nam results in no significant difference in lifespan compared to growing mutant worms in the absence of Nam. |
van der Horst et al. |
2007 |
17335870 |
doi:10.1016/j.mad.2007.01.004 |
Lifespan Observations Database (ID: 3526) |
341 |
OB_001962 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
F37C4.4 |
Caenorhabditis elegans |
177145 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-40.82% |
8.7 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3266) |
342 |
OB_001963 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
npp-3 |
Caenorhabditis elegans |
174823 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-40.82% |
8.7 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3267) |
343 |
OB_002951 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
non-null recessive |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-41.38% |
11.9 |
20.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi inactivation of 23 essential genes specifically during adulthood extends life span. |
Chen et al. |
2007 |
17521386 |
doi:10.1111/j.1474-9726.2007.00305.x |
Lifespan Observations Database (ID: 4271) |
344 |
OB_001954 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
Y77E11A.7 |
Caenorhabditis elegans |
176951 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-41.50% |
8.6 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3259) |
345 |
OB_001956 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ada-2 |
Caenorhabditis elegans |
174194 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-41.50% |
8.6 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3260) |
346 |
OB_001957 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
vrk-1 |
Caenorhabditis elegans |
174004 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-41.50% |
8.6 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3261) |
347 |
OB_001958 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
lmn-1 |
Caenorhabditis elegans |
172687 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-41.50% |
8.6 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3262) |
348 |
OB_001959 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
B0395.2 |
Caenorhabditis elegans |
181681 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-41.50% |
8.6 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3263) |
349 |
OB_001960 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
ulp-1 |
Caenorhabditis elegans |
175704 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-41.50% |
8.6 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3264) |
350 |
OB_001961 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
Y47G6A.18 |
Caenorhabditis elegans |
171919 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-41.50% |
8.6 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3265) |
351 |
OB_001953 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
smn-1 |
Caenorhabditis elegans |
172783 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-42.18% |
8.5 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3258) |
352 |
OB_001947 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ccr-4 |
Caenorhabditis elegans |
178184 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-42.86% |
8.4 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3252) |
353 |
OB_001948 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
F55B12.4 |
Caenorhabditis elegans |
3565786 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-42.86% |
8.4 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3253) |
354 |
OB_001949 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
mep-1 |
Caenorhabditis elegans |
178074 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-42.86% |
8.4 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3254) |
355 |
OB_001950 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C33H5.18 |
Caenorhabditis elegans |
3565046 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-42.86% |
8.4 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3255) |
356 |
OB_001951 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C11H1.3 |
Caenorhabditis elegans |
181537 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-42.86% |
8.4 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3256) |
357 |
OB_001952 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C01F1.1 |
Caenorhabditis elegans |
173764 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-42.86% |
8.4 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3257) |
358 |
OB_001942 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cel-1 |
Caenorhabditis elegans |
172814 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-43.54% |
8.3 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3248) |
359 |
OB_001943 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
M03F4.7 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-43.54% |
8.3 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3249) |
360 |
OB_001945 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C07A9.2 |
Caenorhabditis elegans |
176368 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-43.54% |
8.3 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3250) |
361 |
OB_001946 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C40H5.6 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-43.54% |
8.3 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3251) |
362 |
OB_001941 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
Y39G10AL.3 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-44.22% |
8.2 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3247) |
363 |
OB_001714 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-44.90% |
8.1 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3042) |
364 |
OB_001937 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
F33H2.8 |
Caenorhabditis elegans |
185238 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-44.90% |
8.1 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3243) |
365 |
OB_001938 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
spl-1 |
Caenorhabditis elegans |
176857 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-44.90% |
8.1 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3244) |
366 |
OB_001939 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C26B9.3 |
Caenorhabditis elegans |
180804 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-44.90% |
8.1 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3245) |
367 |
OB_001940 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
Y57A10A.19 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-44.90% |
8.1 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3246) |
368 |
OB_007355 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNA interference |
- |
wildtype |
yes |
|
|
|
decreased |
-45.00% |
|
|
|
Average |
|
|
|
70% decrease in median lifespan in daf-2 background and 45% decrease in lifespan in wild-type background. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
GenAge |
369 |
OB_001934 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
rab-7 |
Caenorhabditis elegans |
174834 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-45.58% |
8 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3240) |
370 |
OB_001935 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
F30A10.10 |
Caenorhabditis elegans |
172782 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-45.58% |
8 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3241) |
371 |
OB_001936 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
pnk-1 |
Caenorhabditis elegans |
172327 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-45.58% |
8 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3242) |
372 |
OB_001932 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
F25D7.3, blmp-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-46.94% |
7.8 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3239) |
373 |
OB_001931 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
npp-2 |
Caenorhabditis elegans |
172611 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-47.62% |
7.7 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3238) |
374 |
OB_001929 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C35C5.1, sdc-2 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-48.30% |
7.6 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3236) |
375 |
OB_001930 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
let-765 |
Caenorhabditis elegans |
175934 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-48.30% |
7.6 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3237) |
376 |
OB_001927 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
Y59A8B.2 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-48.98% |
7.5 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3234) |
377 |
OB_001928 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
CD4.4 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-48.98% |
7.5 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3235) |
378 |
OB_001925 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
C06A5.1 |
Caenorhabditis elegans |
182280 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-49.66% |
7.4 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3232) |
379 |
OB_001926 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
egr-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-49.66% |
7.4 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3233) |
380 |
OB_003406 |
Caenorhabditis elegans |
rrf-3(pk1426);glp-4(bn2) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Pathogen resistance |
Worms were infected at 25 C by feeding on PA14 lawns. |
|
decreased |
-49.85% |
34.1 |
68 |
|
mean |
25 |
℃ |
|
Knock-down of daf-16 by RNA interference (RNAi) in rrf-3(pk1426); glp-4(bn2) animals rendered these animals significantly more susceptible to PA14. Lifespan was approximately 50% shorter than control. |
Evans et al. |
2008 |
18782349 |
doi:10.1111/j.1474-9726.2008.00435.x |
Lifespan Observations Database (ID: 4832) |
381 |
OB_001924 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
ZC250.3 |
Caenorhabditis elegans |
191128 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-50.34% |
7.3 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3231) |
382 |
OB_001921 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
mxl-2 |
Caenorhabditis elegans |
175184 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-51.70% |
7.1 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3229) |
383 |
OB_001923 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
T27F7.1 |
Caenorhabditis elegans |
173863 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-51.70% |
7.1 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3230) |
384 |
OB_001919 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
T19B10.2 |
Caenorhabditis elegans |
179551 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-53.06% |
6.9 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3227) |
385 |
OB_001920 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
W04G3.2 |
Caenorhabditis elegans |
181297 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-53.06% |
6.9 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3228) |
386 |
OB_001918 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
glf-1 |
Caenorhabditis elegans |
177358 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-55.78% |
6.5 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3226) |
387 |
OB_001916 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
vps-20 |
Caenorhabditis elegans |
171654 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-56.46% |
6.4 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3224) |
388 |
OB_001917 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
F43D2.1 |
Caenorhabditis elegans |
185704 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-56.46% |
6.4 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3225) |
389 |
OB_001915 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cyp-42A1 |
Caenorhabditis elegans |
180236 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-57.82% |
6.2 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3223) |
390 |
OB_001914 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
Y39C12A.2 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-61.22% |
5.7 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3222) |
391 |
OB_001913 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
ufd-1 |
Caenorhabditis elegans |
3565860 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-61.90% |
5.6 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3221) |
392 |
OB_001912 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
M05B5.2 |
Caenorhabditis elegans |
187451 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-62.59% |
5.5 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3220) |
393 |
OB_001910 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
hsf-1 |
Caenorhabditis elegans |
173078 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-63.27% |
5.4 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3219) |
394 |
OB_001909 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
tag-249 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-63.95% |
5.3 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3218) |
395 |
OB_003467 |
Caenorhabditis elegans |
daf-2(e1370) |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
|
|
|
decreased |
-65.97% |
13 |
38.2 |
days |
mean |
20 |
℃ |
|
Mean lifespan of daf-2(e1370);daf-16(mu86) double mutant was approximately 66% shorter than the daf-2(e1370) control. |
Takahashi et al. |
2011 |
21531333 |
doi:10.1016/j.cmet.2011.03.017 |
Lifespan Observations Database (ID: 4895) |
396 |
OB_001908 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
arx-4 |
Caenorhabditis elegans |
175247 |
RNAi knockdown |
- |
unknown |
unknown |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
|
|
|
decreased |
-66.67% |
4.9 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3217) |
397 |
OB_000329 |
Caenorhabditis elegans |
Bristol N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
over-expression |
- |
unknown |
unknown |
|
|
|
increased |
|
|
|
|
|
|
|
|
Overexpression of daf-16 modestly increases life-span (~20%). Other phenotypes: Loss of function allele shortens life span. Some alleles have life span equal to wild type. daf-16 is required for life span extension by mutation of daf-2 or age-1 [ 8247153]. daf-16 mutants are dauer defective [ 7219552]. Mutation of daf-16 completely suppresses all the phenotypes of daf-2 and age-1 mutants, including life span extension, dauer arrest, reduced fertility, and viability defects [ 8247153]. |
Henderson et al. |
2001 |
11747825 |
|
Lifespan Observations Database (ID: 156) |
398 |
OB_003743 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mgDf50 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Malate |
10 |
mM |
|
|
none |
|
|
|
days |
mean |
20 |
℃ |
|
Treatment with malate did not extend the lifespan of daf-16(mgDf50) worms. |
Edwards et al. |
2013 |
23472183 |
doi:10.1371/journal.pone.0058345 |
Lifespan Observations Database (ID: 5276) |