Gene: tbp-1 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | tbp-1 | ||||||||||||||||
NCBI Gene ID | : | 176054 | ||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||
Gene Synonyms | : | 3H475 | CE01408 | CELE_T20B12.2 | Protein TBP-1 | T20B12.2 | T20B12.2.1 | T20B12.2.2 | TBP | tbp | tbp-1 | WP:CE01408 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP010958 (Anopheles gambiae) | AGOS_AGR134W (Eremothecium gossypii) | KLLA0E10099g (Kluyveromyces lactis) | MGG_08878 (Magnaporthe oryzae) | NCU04770 (Neurospora crassa) | Os10g0432300 (Oryza sativa) | SPT15 (Saccharomyces cerevisiae) | TBP (Bos taurus) | TBP (Canis lupus familiaris) | tbp (Danio rerio) | Tbp (Drosophila melanogaster) | TBP (Gallus gallus) | TBP (Homo sapiens) | TBP (Macaca mulatta) | Tbp (Mus musculus) | TBP (Pan troglodytes) | Tbp (Rattus norvegicus) | tbp-1 (Caenorhabditis elegans) | tbp1 (Schizosaccharomyces pombe) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_006074 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
TATA-box-binding protein | Caenorhabditis elegans | P32085 (UniProtKB/Swiss-Prot) | TBP_CAEEL (UniProtKB/Swiss-Prot) | General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_006604 | Caenorhabditis elegans |
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decreased | -21.00% | Average | 21% mean decrease in lifespan | Xue et al. | 2007 | 18059442 | doi:10.1038/msb4100189 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008951 | 2 | The HomoloGene homology group 2404 contains 2 genes with experimental evidence for ageing relevance (TBP - Homo sapiens | tbp-1 - Caenorhabditis elegans) and 17 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 2404 |
Sequences
TBP_CAEEL | P32085 | TATA-box-binding protein (Caenorhabditis elegans) from UniProtKB/Swiss-Prot Length: 340 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 TBP_CAEEL 1 MNLNSPAVSMLGGDTPAHGGPNSVLGGQGPSSILTGHGPNSVMGPNSILGPGSVLNPQSIQPMQSQQMHSLQGSSMQMHSHLANSNLNLNINPASVGPDRNPGSVMHHNLDINPPSVAYQNLTVPMTPLAYSVYDRDALTHQAPASNIAATMVPATPASQLDIPMPALQNIVSTVNLGVQLDLKKIALHARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEASRLAARKYARIVQKLGFQAKFTEFMVQNMVGSCDVRFPIQLEGLCITHSQFSTYEPELFPGLIYRMVKPRVVLLIFVSGKVVITGAKTKRDIDEAFGQIYPILKGFKK 340
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Xue H, Xian B, Dong D, Xia K, Zhu S, Zhang Z, Hou L, Zhang Q, Zhang Y, Han JD:
A modular network model of aging.
Mol Syst Biol. 2007; 3: 147.
PubMed (ID: 18059442), PubMed Central (ID: PMC2174624), doi:10.1038/msb4100189
MeSH Terms: Aging/physiology; Models, Biological
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot