Gene: iff-1 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | iff-1 | ||||||||||||||||||||||||
NCBI Gene ID | : | 176373 | ||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||
Gene Synonyms | : | CE37787 | CELE_T05G5.10 | iff-1 | Protein IFF-1 | T05G5.10 | WP:CE37787 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP011284 (Anopheles gambiae) | eIF-5A (Drosophila melanogaster) | EIF5A2 (Bos taurus) | EIF5A2 (Canis lupus familiaris) | eif5a2 (Danio rerio) | EIF5A2 (Gallus gallus) | EIF5A2 (Homo sapiens) | EIF5A2 (Macaca mulatta) | Eif5a2 (Mus musculus) | EIF5A2 (Pan troglodytes) | Eif5a2 (Rattus norvegicus) | iff-1 (Caenorhabditis elegans) | iff-2 (Caenorhabditis elegans) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_006119 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Eukaryotic translation initiation factor 5A-1 | Caenorhabditis elegans | P34563 (UniProtKB/Swiss-Prot) | IF5A1_CAEEL (UniProtKB/Swiss-Prot) | mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity). Required for mitotic germ cell proliferation, gametogenesis after entry into meiosis, and localization of the P granule component pgl-1 on P granules. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_001900 | Caenorhabditis elegans | sir-2.1 (ok434); rrf-3 (pk1426) |
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increased | 11.00% | RNAi knockdown in the sir-2.1 (ok434); rrf-3 (pk1426) background increases lifespan by 11%. | Hamilton et al. | 2005 | 15998808 | doi:10.1101/gad.1308205 | Lifespan Observations Database (ID: 320) | |||||||||||||||||||||||
2 | OB_001340 | Caenorhabditis elegans | rrf-3(pk1426) |
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increased | 10.00% | RNA interference in the rrf-3(pk1426) background leads to lifespan extension of about 10%. | Hamilton et al. | 2005 | 15998808 | doi:10.1101/gad.1308205 | Lifespan Observations Database (ID: 265) | |||||||||||||||||||||||
3 | OB_005411 | Caenorhabditis elegans |
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increased | unknown | RNA interference extended lifespan. | Hamilton et al. | 2005 | 15998808 | doi:10.1101/gad.1308205 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008695 | 2 | The HomoloGene homology group 1490 contains 2 genes with experimental evidence for ageing relevance (Eif5a2 - Mus musculus | iff-1 - Caenorhabditis elegans) and 11 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 1490 |
Sequences
IF5A1_CAEEL | P34563 | Eukaryotic translation initiation factor 5A-1 (Caenorhabditis elegans) from UniProtKB/Swiss-Prot Length: 161 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 IF5A1_CAEEL 1 MSEDHHDEEQFDSAESGAAATFPKQCSALRKNEHVMIRGRPCKIVEMSTSKTGKHGHAKVHMVAIDIFTTKKLEDICPSTHNMDVPVVKRREYILMSIEDGFCSLMDPESCELKDDLKMPEGDLGNTIREALEKDEGSVLVQVVAACGEEAILGYKISTKE 161
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS:
A systematic RNAi screen for longevity genes in C. elegans.
Genes Dev. 2005; 19: 1544-55.
PubMed (ID: 15998808), PubMed Central (ID: PMC1172061), doi:10.1101/gad.1308205
MeSH Terms: Caenorhabditis elegans/genetics; Longevity/genetics; RNA Interference
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot