Gene: nhx-2 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | nhx-2 | ||||||||||||||||||||||||
NCBI Gene ID | : | 174242 | ||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||
Gene Synonyms | : | CELE_B0495.4 | nhx-2 | Protein NHX-2 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP009036 (Anopheles gambiae) | Nhe2 (Drosophila melanogaster) | nhx-2 (Caenorhabditis elegans) | nhx-3 (Caenorhabditis elegans) | nhx-6 (Caenorhabditis elegans) | nhx-9 (Caenorhabditis elegans) | SLC9A3 (Bos taurus) | SLC9A3 (Gallus gallus) | SLC9A3 (Homo sapiens) | Slc9a3 (Mus musculus) | Slc9a3 (Rattus norvegicus) | slc9a3.1 (Danio rerio) | slc9a3.2 (Danio rerio) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_006295 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Sodium/hydrogen exchanger | Caenorhabditis elegans | Q09432 (UniProtKB/TrEMBL) | Q09432_CAEEL (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_005625 | Caenorhabditis elegans |
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Gene inactivation by RNA interference led to a loss of fat stores in the intestine and a 40% increase in lifespan. | 12939266 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_003897 | Caenorhabditis elegans |
|
increased | 40.00% | Gene inactivation by RNA interference led to a 40% increase in lifespan. Other phenotypes: Also led to a loss of fat stores in the intestine. | Nehrke | 2003 | 12939266 | doi:10.1074/jbc.M307351200 | Lifespan Observations Database (ID: 613) | ||||||||||||||||||||||||
2 | OB_005626 | Caenorhabditis elegans |
|
increased | 40.00% | unknown | Gene inactivation by RNA interference led to a loss of fat stores in the intestine and a 40% increase in lifespan. | Nehrke | 2003 | 12939266 | doi:10.1074/jbc.M307351200 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008988 | 1 | The HomoloGene homology group 55804 contains 1 gene with experimental evidence for ageing relevance (nhx-2 - Caenorhabditis elegans) and 12 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 55804 |
Sequences
Q09432_CAEEL | Q09432 | Sodium/hydrogen exchanger (Caenorhabditis elegans) from UniProtKB/TrEMBL Length: 627 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 Q09432_CAEEL 1 MSYVGAECEEEEKEYPSRYPIAYFEWENVKIPMTICLWLIGASIAKIIFNLIPHLNELFPDSALLIMIGLIIGIIFKLIGVNKNAFFLESEVFMLYLLPPLVFDAGYFMPARQFFDNFGSILCFAMIGTSFNIVAIALSLWAISLTGLFSVETPLMHMLLFGSVAADVDPVAVIVIFEELKVNEVLFIAVFGESLLNDGVAVVLYRMFLTFSEIGTENLITSDYINGGVSFLVVAFGGIGIGLLFAFLTSLVTRFARDEEVKVLNSVFILILPYTCYLCGELFGLSSIMAIVFCGAAMRQYCRENVDPDTVKATESFIKVLSLASETVIFVFLGLSTVSSNHHWDTSFIVLTVVFCLIYRTLGVVVMCYFLNKYRLNKYTKVDQFIMAYGGLRGAIAYGLVVAIPDFIPGKNMFVTSCIIVIYFTVFLQGITLKPIAEFLQVEKKNVHSKNMIEHIYSELIDTTMAGMEDIAGFKGHHWIRDSWNALNNNYLRPILVNKNNMKEMDKTKLVRKYKHLVDEDAKKIARGDLNSNMVFTKALIEHTRSRTNTMIDGVSSTSKIDFTKHMKENFGVTVYDDHSTVPMTPTHLFQETTEVEYSVRSEINDNDGFENDGYESDESGSFHERV 627
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Nehrke K:
A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+/H+ exchanger NHX-2 increases life span.
J Biol Chem. 2003; 278: 44657-66.
PubMed (ID: 12939266), doi:10.1074/jbc.M307351200
MeSH Terms: Caenorhabditis elegans Proteins/physiology; Caenorhabditis elegans/physiology; Sodium-Hydrogen Antiporter/physiology
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- UniProtKB/TrEMBL
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed