Gene: crn-5 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | crn-5 | ||||||||||||||||||||||||
NCBI Gene ID | : | 174634 | ||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||
Gene Synonyms | : | CELE_C14A4.5 | crn-5 | Protein CRN-5 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP002177 (Anopheles gambiae) | AGOS_AAR035C (Eremothecium gossypii) | AT3G46210.1 (Arabidopsis thaliana) | crn-5 (Caenorhabditis elegans) | EXOSC5 (Bos taurus) | EXOSC5 (Canis lupus familiaris) | exosc5 (Danio rerio) | EXOSC5 (Homo sapiens) | EXOSC5 (Macaca mulatta) | Exosc5 (Mus musculus) | EXOSC5 (Pan troglodytes) | Exosc5 (Rattus norvegicus) | KLLA0D14993g (Kluyveromyces lactis) | LOC100858931 (Gallus gallus) | MGG_09936 (Magnaporthe oryzae) | NCU03268 (Neurospora crassa) | Os03g0854200 (Oryza sativa) | Rrp46 (Drosophila melanogaster) | RRP46 (Saccharomyces cerevisiae) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_006334 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Cell death-related nuclease 5 | Caenorhabditis elegans | G5EG59 (UniProtKB/TrEMBL) | G5EG59_CAEEL (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_002921 | Caenorhabditis elegans |
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increased | 41.00% | RNA interference in adulthood resulted in a 41% increase in mean lifespan. | Curran et al. | 2007 | 17411345 | doi:10.1371/journal.pgen.0030056 | Lifespan Observations Database (ID: 423) | ||||||||||||||||||||||||
2 | OB_007018 | Caenorhabditis elegans |
|
increased | 41.00% | Average | RNA interference in adulthood resulted in a 41% increase in mean lifespan. | Curran et al. | 2007 | 17411345 | doi:10.1371/journal.pgen.0030056 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008170 | 1 | The HomoloGene homology group 5981 contains 1 gene with experimental evidence for ageing relevance (crn-5 - Caenorhabditis elegans) and 18 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 5981 |
Sequences
G5EG59_CAEEL | G5EG59 | Cell death-related nuclease 5 (Caenorhabditis elegans) from UniProtKB/TrEMBL Length: 214 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 G5EG59_CAEEL 1 MAGRLREMRCELSFLKNADGSACFSQGATCIWASCSGPGDVHASKASDEAMTLDISYRANCGDNKFNVLNNIIHSTLSNAINLELFPHTTISVTVHGIQDDGSMGAVAINGACFALLDNGMPFETVFCGVLIVRVKDELIIDPTAKQEAASTGRVLFSVCKGSDGHPEVCAMDAIGHWDFIQLEAAWSLAQPSASAIFDFYKTVMKRKLSVDEQ 214
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Curran SP, Ruvkun G:
Lifespan regulation by evolutionarily conserved genes essential for viability.
PLoS Genet. 2007; 3: e56.
PubMed (ID: 17411345), PubMed Central (ID: PMC1847696), doi:10.1371/journal.pgen.0030056
MeSH Terms: Caenorhabditis elegans/genetics; Caenorhabditis elegans/physiology; Conserved Sequence/genetics; Evolution, Molecular; Genes, Essential; Genes, Helminth; Longevity/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/TrEMBL