Gene: nnt-1 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | nnt-1 | ||||||||||||||||||||||||
NCBI Gene ID | : | 180884 | ||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||
Gene Synonyms | : | CELE_C15H9.1 | nnt-1 | Protein NNT-1 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP003167 (Anopheles gambiae) | MGG_07539 (Magnaporthe oryzae) | NCU01140 (Neurospora crassa) | NNT (Bos taurus) | NNT (Canis lupus familiaris) | nnt (Danio rerio) | NNT (Gallus gallus) | NNT (Homo sapiens) | NNT (Macaca mulatta) | NNT (Pan troglodytes) | Nnt (Rattus norvegicus) | nnt-1 (Caenorhabditis elegans) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_006339 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Protein NNT-1 | Caenorhabditis elegans | Q18031 (UniProtKB/TrEMBL) | Q18031_CAEEL (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_005627 | Caenorhabditis elegans |
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nnt-1 appears to inhibit the growth of gld-1 tumours. RNA interference reduced mean lifespan up to 18% in wild type animals, 20% in daf-2 mutants and 16% in daf-2/gld-1 mutants. | 17934462 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_003899 | Caenorhabditis elegans |
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increased | 20.00% | RNA interference reduced mean lifespan up to 20% in daf-2 mutants. Other phenotypes: nnt-1 appears to inhibit the growth of gld-1 tumours. | Pinkston-Gosse et al. | 2007 | 17934462 | doi:10.1038/ng.2007.1 | Lifespan Observations Database (ID: 615) | ||||||||||||||||||||||||
2 | OB_003898 | Caenorhabditis elegans |
|
increased | 18.00% | RNA interference reduced mean lifespan up to 18% in wild type animals. Other phenotypes: nnt-1 appears to inhibit the growth of gld-1 tumours. | Pinkston-Gosse et al. | 2007 | 17934462 | doi:10.1038/ng.2007.1 | Lifespan Observations Database (ID: 614) | ||||||||||||||||||||||||
3 | OB_003900 | Caenorhabditis elegans |
|
increased | 16.00% | RNA interference reduced mean lifespan up to 16% in daf-2/gld-1 mutants. Other phenotypes: nnt-1 appears to inhibit the growth of gld-1 tumours. | Pinkston-Gosse et al. | 2007 | 17934462 | doi:10.1038/ng.2007.1 | Lifespan Observations Database (ID: 616) | ||||||||||||||||||||||||
4 | OB_005628 | Caenorhabditis elegans |
|
decreased | -18.00% | Average | nnt-1 appears to inhibit the growth of gld-1 tumours. RNA interference reduced mean lifespan up to 18% in wild type animals, 20% in daf-2 mutants and 16% in daf-2/gld-1 mutants. | Pinkston-Gosse et al. | 2007 | 17934462 | doi:10.1038/ng.2007.1 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_009108 | 1 | The HomoloGene homology group 7445 contains 1 gene with experimental evidence for ageing relevance (nnt-1 - Caenorhabditis elegans) and 11 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 7445 |
Sequences
Q18031_CAEEL | Q18031 | Protein NNT-1 (Caenorhabditis elegans) from UniProtKB/TrEMBL Length: 1041 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 Q18031_CAEEL 1 MVILRSKITRLYWFRLFSNGQKKIEYSKLKVAVPKEIFPGEKRVSLSPNGVALLKKNGISVLIEENAGVLAGYSNEEYVRSGADVGKHNEVFNTDIMLKVRPPTENEVSKLKSGCTLISFIHPGQNQALLDSLTKTDKTVFAMDCVPRISRAQVFDALSSMANIAGYRAVIEAANHFGRFFTGQITAAGKVPPAKVLVIGGGVAGLSAIGTSRGMGAVVRGFDTRAAVKEHVESLGAQFLTVNVKEDGEGGGGYAKEMSKEFIDAEMKLFADQCKDVDIIITTALIPGKKAPILITEEMIKSMKPGSVVVDLAAESGGNIATTRPGEVYVKHGVTHIGFTDLPSRLPTQSSELYSNNIAKFLLHLGKDKTFFVNEEDEVARGALVVRDGQMKWPPPPINFPPPAAPKSDKPSENTALVPLTPFRKTANQTLLLTSGLGSVSLLGIAGTNPQISSMSTTFALAGLVGYHTVWGVTPALHSPLMSVTNAISGTTAAGALCLMGGGLMPQNSAQTMALLATFISSVNIGGGFLVTKRMLDMFKRKDDPPEHNYLFSIPAAVFLGGYGYGVYTAAPLIHSYAYLGSSLCCVGALAGLSSQSTARVGNALGIIGVTGGIGATLGLLQPDFNTLCQMGGSVAMGSLIGLGIANRIKVTDLPQLVAAFHSFVGLAATLTCLANFIQEHPHFLEDPSNAAAAKLALFLGTYIGGVTFTGSLMAYGKLQGILASAPTYLPARHVLNGALLAGNVGALGTYMYSTDFGTGMSMLGGTVGLSSLMGVTLTMAIGGADMPIVITVLNSYSGWALCAEGFMLDNSLLTVLGALIGSSGAILSHIMCKAMNRSLLNVILGGVGTKSKGTGEAKAIEGTAKEIAPVETADMLLNARSVIIIPGYGLCAAQAQYPIAQLVKELQQRGVRVRFAIHPVAGRMPGQLNVLLAEAGVPYDIVEEMEEINEDFKETDVALVIGSNDTINSAAEDDPNSSIAGMPVLRVWNSKQVIIVKRTLGTGYAAVDNPVFFNENTQMLLGDAKKMSEKLLEEVKSKPM 1041
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Pinkston-Gosse J, Kenyon C:
DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans.
Nat Genet. 2007; 39: 1403-9.
PubMed (ID: 17934462), doi:10.1038/ng.2007.1
MeSH Terms: Aging/genetics; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans/genetics; Gene Expression Regulation, Developmental; Neoplasms/pathology; Transcription Factors/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- UniProtKB/TrEMBL
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed