Gene: lys-8 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | lys-8 | ||||||||||||||||||||
NCBI Gene ID | : | 173944 | ||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||
Gene Synonyms | : | CELE_C17G10.5 | lys-8 | Protein LYS-8 Source: GPSDB |
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Gene Homologs | : | |||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_006346 | ||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Protein LYS-8 | Caenorhabditis elegans | Q09975 (UniProtKB/TrEMBL) | Q09975_CAEEL (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_005525 | Caenorhabditis elegans |
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lys-8 appears to inhibit the growth of gld-1 tumours. RNA interference reduced mean lifespan up to 29% in wild type animals, up to 19% in daf-2 mutants, and up to 15% in daf-2/gld-1 mutants. It also reduced maximum lifespan 12% in daf-2 mutants and 25% in daf-2/gld-1 mutants. | 17934462 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_003862 | Caenorhabditis elegans |
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increased | 29.00% | RNA interference reduced mean lifespan up to 29% in wild type animals. Other phenotypes: lys-8 appears to inhibit the growth of gld-1 tumours. | Pinkston-Gosse et al. | 2007 | 17934462 | doi:10.1038/ng.2007.1 | Lifespan Observations Database (ID: 582) | ||||||||||||||||||||||||
2 | OB_003863 | Caenorhabditis elegans |
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increased | 19.00% | RNA interference reduced mean lifespan up to 19% in daf-2 mutants. Other phenotypes: lys-8 appears to inhibit the growth of gld-1 tumours. | Pinkston-Gosse et al. | 2007 | 17934462 | doi:10.1038/ng.2007.1 | Lifespan Observations Database (ID: 583) | ||||||||||||||||||||||||
3 | OB_005526 | Caenorhabditis elegans |
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decreased | -29.00% | Average | lys-8 appears to inhibit the growth of gld-1 tumours. RNA interference reduced mean lifespan up to 29% in wild type animals, up to 19% in daf-2 mutants, and up to 15% in daf-2/gld-1 mutants. It also reduced maximum lifespan 12% in daf-2 mutants and 25% in daf-2/gld-1 mutants. | Pinkston-Gosse et al. | 2007 | 17934462 | doi:10.1038/ng.2007.1 | GenAge |
Homology Analysis
no homology analysis observation available
Sequences
Q09975_CAEEL | Q09975 | Protein LYS-8 (Caenorhabditis elegans) from UniProtKB/TrEMBL Length: 286 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 Q09975_CAEEL 1 MLLKSVALLSVLAVLCHSASVSVKVLPFVDSSLPVKFREVIAEAAPRVPPNLASYAFAVDLSVPVSLSQLQCLKQAGYSAVFVRAYNPAGQGSFDTNSCNTIQNAYNAGLGTEIYMTPQPASSKQGYQQLDEIYQGLTARGITIRSVWIQVTSPTNWPSNANNNVNFINSIVSRARQYGMTVGIYTSYYDWNQITNGWSSIGNDVLLWYWNVLGGGVNGETPASFADFRAFGCWTTPSVKQFAQVEQVCQFTVNRDVYAAGTMLKAADAVEEDGKIYAGGFIQGSQ 286
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Pinkston-Gosse J, Kenyon C:
DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans.
Nat Genet. 2007; 39: 1403-9.
PubMed (ID: 17934462), doi:10.1038/ng.2007.1
MeSH Terms: Aging/genetics; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans/genetics; Gene Expression Regulation, Developmental; Neoplasms/pathology; Transcription Factors/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- NCBI Taxonomy
- PubMed
- UniProtKB/TrEMBL