Gene: asb-2 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | asb-2 | ||||||||||||||||||||||||
NCBI Gene ID | : | 180718 | ||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||
Gene Synonyms | : | asb-2 | CELE_F02E8.1 | Protein ASB-2 Source: GPSDB |
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Gene Homologs | : | asb-1 (Caenorhabditis elegans) | asb-2 (Caenorhabditis elegans) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_006462 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Protein ASB-2 | Caenorhabditis elegans | Q19126 (UniProtKB/TrEMBL) | Q19126_CAEEL (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||||||||||||||||
1 | OB_002152 | Caenorhabditis elegans | N2 |
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increased | 205.21% | 58.6 | 19.2 | days | mean | 20 | ℃ | hermaphrodite | For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased daf-2 lifespan by 52% relative to daf-2 lifespan alone. | Hansen et al. | 2005 | 16103914 | doi:10.1371/journal.pgen.0010017 | Lifespan Observations Database (ID: 3437) | ||||||||||||||||||||||||||||||
2 | OB_002053 | Caenorhabditis elegans | N2 |
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increased | 46.41% | 26.5 | 18.1 | days | mean | 20 | ℃ | hermaphrodite | RNA knockdown extended N2 lifespan. | Hansen et al. | 2005 | 16103914 | doi:10.1371/journal.pgen.0010017 | Lifespan Observations Database (ID: 3348) | ||||||||||||||||||||||||||||||
3 | OB_002229 | Caenorhabditis elegans | N2 |
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increased | 25.66% | 19.1 | 15.2 | days | mean | 25 | ℃ | hermaphrodite | For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown extended lifespan of fer-15;fem-1 mutants by 19% relative to fer-15;fem-1 lifespan. | Hansen et al. | 2005 | 16103914 | doi:10.1371/journal.pgen.0010017 | Lifespan Observations Database (ID: 3506) | ||||||||||||||||||||||||||||||
4 | OB_002134 | Caenorhabditis elegans | N2 |
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increased | 10.42% | 21.2 | 19.2 | days | mean | 20 | ℃ | hermaphrodite | For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of daf-16 mutants by 65% relative to daf-16 mutant lifespan alone. | Hansen et al. | 2005 | 16103914 | doi:10.1371/journal.pgen.0010017 | Lifespan Observations Database (ID: 3420) | ||||||||||||||||||||||||||||||
5 | OB_007529 | Caenorhabditis elegans |
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increased | unknown | RNA interference leads to lifespan extension. | Hansen et al. | 2005 | 16103914 | doi:10.1371/journal.pgen.0010017 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | |||||||||
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1 | OB_008171 |
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1 | The HomoloGene homology group 119364 contains 1 gene with experimental evidence for ageing relevance (asb-2 - Caenorhabditis elegans) and 1 other gene. | AgeFactDB Homology Analysis | HomoloGene homology group 119364 |
Sequences
Q19126_CAEEL | Q19126 | Protein ASB-2 (Caenorhabditis elegans) from UniProtKB/TrEMBL Length: 305 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 Q19126_CAEEL 1 MSLSRCLPLGQNARVIIIPARLAHAASTQAAAATDDAPNFFQKLAHRFQGVPLKGEAHAPKSMFEDCNKEWSAPEPLPAIPKDFKEHPDRDLVNYPYPARPMYPPKSRLLMMPDSWFTPFQKVTGVSGPYLFFGGLFAFLVNKELWVFEEQGHMTVGWILFYLLVTRTAGYKIDQGLYNGYQERVNFFKGLIQEDLKEAVEFKKTSAKQTESLNSIKESYPTALKESMALQLEATYRKNVQSVATELKRRIDYLKETEESKARVEREQLLKLINSEVDKEFSDRSFKDKYLQNAIQQLKGLNVQL 305
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Hansen M, Hsu AL, Dillin A, Kenyon C:
New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen.
PLoS Genet. 2005; 1: 119-28.
PubMed (ID: 16103914), PubMed Central (ID: PMC1183531), doi:10.1371/journal.pgen.0010017
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/TrEMBL