1 |
OB_000021 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
increased |
165.82% |
52.1 |
19.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of daf-2 increased life span additively with deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1019) |
2 |
OB_000020 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
increased |
150.25% |
49.3 |
19.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of daf-2 increased life span additively with deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1018) |
3 |
OB_000019 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
increased |
76.50% |
38.3 |
21.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of daf-2 increased life span additively with deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1017) |
4 |
OB_000015 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation |
|
increased |
72.20% |
41.5 |
24.1 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of vhl-1 increased life span additively with dietary restriction by bacterial deprivation. These data support the model that VHL-1 and dietary restriction act in parallel pathways to promote longevity. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1013) |
5 |
OB_000016 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation |
|
increased |
68.53% |
39.1 |
23.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of vhl-1 increased life span additively with dietary restriction by bacterial deprivation. These data support the model that VHL-1 and dietary restriction act in parallel pathways to promote longevity. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1014) |
6 |
OB_000012 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
increased |
61.73% |
31.7 |
19.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1010) |
7 |
OB_000037 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
57.14% |
29.7 |
18.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1033) |
8 |
OB_000035 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
51.85% |
28.7 |
18.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1031) |
9 |
OB_000009 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
increased |
51.61% |
32.9 |
21.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1008) |
10 |
OB_000027 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation |
|
increased |
51.60% |
33.2 |
21.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Dietary restriction by bacterial deprivation significantly increased the life span of vhl-1(ok161); hif-1(ia04) double mutant animals. These data support the model that dietary restriction acts in a longevity pathway parallel to VHL-1/HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1024) |
11 |
OB_000028 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation |
|
increased |
49.38% |
36 |
24.1 |
days |
mean |
20 |
℃ |
hermaphrodite |
Dietary restriction by bacterial deprivation significantly increased the life span of vhl-1(ok161); hif-1(ia04) double mutant animals. These data support the model that dietary restriction acts in a longevity pathway parallel to VHL-1/HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1025) |
12 |
OB_000010 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
increased |
46.19% |
28.8 |
19.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1009) |
13 |
OB_000006 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
increased |
42.92% |
30.3 |
21.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1005) |
14 |
OB_000005 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
increased |
36.52% |
31.4 |
23 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1004) |
15 |
OB_000017 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
increased |
31.12% |
25.7 |
19.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of daf-16 failed to prevent life span extension from deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1015) |
16 |
OB_000007 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
increased |
30.89% |
32.2 |
24.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1006) |
17 |
OB_006617 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNA interference |
- |
wildtype |
yes |
|
|
|
increased |
30.00% |
|
|
|
Average |
|
|
|
Loss of VHL-1 significantly increased average lifespan (by 30%) and enhanced resistance to polyglutamine and amyloid beta toxicity, no change in MLS |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
GenAge |
18 |
OB_000029 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation |
|
increased |
29.95% |
28.2 |
21.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of daf-2 significantly increased the life span of vhl-1(ok161); hif-1(ia04) double mutant animals. These data support the model that insulin-like signaling acts in a longevity pathway parallel to VHL-1/HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1026) |
19 |
OB_000008 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
increased |
29.88% |
31.3 |
24.1 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1007) |
20 |
OB_000014 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
increased |
28.45% |
29.8 |
23.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1012) |
21 |
OB_000031 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
25.87% |
25.3 |
20.1 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1028) |
22 |
OB_000036 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
24.06% |
23.2 |
18.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1032) |
23 |
OB_000032 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
22.64% |
26 |
21.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1029) |
24 |
OB_000034 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
18.44% |
28.9 |
24.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1030) |
25 |
OB_000013 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
increased |
12.45% |
28.9 |
25.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1011) |
26 |
OB_000030 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
11.92% |
21.6 |
19.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of vhl-1 significantly increased life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1027) |
27 |
OB_000038 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
11.63% |
24 |
21.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1034) |
28 |
OB_000041 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
7.11% |
22.6 |
21.1 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1037) |
29 |
OB_003776 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
flcn-1 |
Caenorhabditis elegans |
|
loss of function |
ok975 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
HT115 |
unknown |
unknown |
|
|
|
none |
3.96% |
20.99 |
20.19 |
days |
mean |
20 |
℃ |
|
Wildtype and flcn-1 deficient worms grown on RNAi against vhl-1 display a nearly identical lifespan. |
Gharbi et al. |
2013 |
23566034 |
doi:10.1111/acel.12081 |
Lifespan Observations Database (ID: 5357) |
30 |
OB_000040 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
none |
3.69% |
25.3 |
24.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1036) |
31 |
OB_000025 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
none |
1.22% |
24.8 |
24.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1022) |
32 |
OB_003777 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
flcn-1 |
Caenorhabditis elegans |
|
loss of function |
ok975 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
HT115 |
unknown |
unknown |
|
|
|
none |
0.00% |
19.5 |
19.5 |
days |
max |
20 |
℃ |
|
Wildtype and flcn-1 deficient worms grown on RNAi against vhl-1 display a nearly identical lifespan. |
Gharbi et al. |
2013 |
23566034 |
doi:10.1111/acel.12081 |
Lifespan Observations Database (ID: 5358) |
33 |
OB_000039 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
none |
-0.93% |
21.4 |
21.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1035) |
34 |
OB_004270 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mu86 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
none |
-1.03% |
19.2 |
19.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of vhl-1 in daf-16(mu86) animals resulted in a life span that was comparable to wild type animals but longer than daf-16(mu86) animals. This experiment supports the model that life span extension from reduced vhl-1 activity increases life span by a DAF-16-independent mechanism. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 967) |
35 |
OB_000026 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
none |
-1.66% |
23.7 |
24.1 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1023) |
36 |
OB_000024 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
none |
-2.76% |
21.1 |
21.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1021) |
37 |
OB_000018 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
decreased |
-8.95% |
23.4 |
25.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of daf-16 failed to prevent life span extension from deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1016) |
38 |
OB_000023 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
decreased |
-10.05% |
19.7 |
21.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1020) |
39 |
OB_006619 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNA interference |
- |
wildtype |
yes |
|
|
|
increased |
|
|
|
|
unknown |
|
|
|
Loss of vhl-1 significantly increased lifespan and resulted in accelerated basal signaling of the p38 mitogen-activated protein kinase PMK-3. |
Müller et al. |
2009 |
19797165 |
doi:10.1681/ASN.2009050497 |
GenAge |