1 |
OB_002350 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
kri-1 |
Caenorhabditis elegans |
191275 |
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
increased |
188.46% |
52.5 |
18.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA interference increased lifespan 112% relative to double mutant lifespan. |
Berman et al. |
2006 |
16530050 |
doi:10.1016/j.cell.2006.01.039 |
Lifespan Observations Database (ID: 3621) |
2 |
OB_002347 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
increased |
157.69% |
46.9 |
18.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Double mutation extended lifespan approximately 158%. |
Berman et al. |
2006 |
16530050 |
doi:10.1016/j.cell.2006.01.039 |
Lifespan Observations Database (ID: 3619) |
3 |
OB_004285 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
egl-9 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
increased |
67.72% |
31.7 |
18.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of egl-9 in the RNAi sensitive rrf-3(pk1426) background significantly increased life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 980) |
4 |
OB_002354 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1368 |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
increased |
66.48% |
30.3 |
18.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Double mutation extended lifespan 66%. |
Berman et al. |
2006 |
16530050 |
doi:10.1016/j.cell.2006.01.039 |
Lifespan Observations Database (ID: 3625) |
5 |
OB_000037 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
57.14% |
29.7 |
18.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1033) |
6 |
OB_000035 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
51.85% |
28.7 |
18.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1031) |
7 |
OB_004282 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
egl-9 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
increased |
48.68% |
28.1 |
18.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of egl-9 in the RNAi sensitive rrf-3(pk1426) background significantly increased life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 978) |
8 |
OB_002356 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1368 |
unknown |
unknown |
kri-1 |
Caenorhabditis elegans |
191275 |
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
increased |
37.91% |
25.1 |
18.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA interference suppressed lifespan extension by 17% relative to double mutant. |
Berman et al. |
2006 |
16530050 |
doi:10.1016/j.cell.2006.01.039 |
Lifespan Observations Database (ID: 3627) |
9 |
OB_004281 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
egl-9 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
increased |
35.12% |
27.7 |
20.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of egl-9 in the RNAi sensitive rrf-3(pk1426) background significantly increased life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 977) |
10 |
OB_004283 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
egl-9 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
increased |
31.15% |
32 |
24.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of egl-9 in the RNAi sensitive rrf-3(pk1426) background significantly increased life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 979) |
11 |
OB_000031 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
25.87% |
25.3 |
20.1 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1028) |
12 |
OB_000036 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
24.06% |
23.2 |
18.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1032) |
13 |
OB_000032 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
22.64% |
26 |
21.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1029) |
14 |
OB_000034 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
18.44% |
28.9 |
24.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1030) |
15 |
OB_002349 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
increased |
14.29% |
20.8 |
18.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA interferenced suppressed lifespan 56% relative to double mutant lifespan. |
Berman et al. |
2006 |
16530050 |
doi:10.1016/j.cell.2006.01.039 |
Lifespan Observations Database (ID: 3620) |
16 |
OB_000038 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
11.63% |
24 |
21.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1034) |
17 |
OB_002355 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1368 |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
increased |
7.14% |
19.5 |
18.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNA interference suppressed lifespan extension by 36% relative to double mutant. |
Berman et al. |
2006 |
16530050 |
doi:10.1016/j.cell.2006.01.039 |
Lifespan Observations Database (ID: 3626) |
18 |
OB_000041 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
7.11% |
22.6 |
21.1 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1037) |
19 |
OB_000040 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
none |
3.69% |
25.3 |
24.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1036) |
20 |
OB_000001 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
none |
0.00% |
24.4 |
24.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1000) |
21 |
OB_000039 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
none |
-0.93% |
21.4 |
21.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1035) |
22 |
OB_004305 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
none |
-2.12% |
18.5 |
18.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 999) |
23 |
OB_000002 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
none |
-4.23% |
18.1 |
18.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1001) |
24 |
OB_000004 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
none |
-4.25% |
20.3 |
21.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1003) |
25 |
OB_000003 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
decreased |
-8.37% |
19.7 |
21.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1002) |