Gene: aqp-1 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | aqp-1 | ||||||||||||||||
NCBI Gene ID | : | 174190 | ||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||
Gene Synonyms | : | aqp-1 | CELE_F32A5.5 | Protein AQP-1 Source: GPSDB |
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Gene Homologs | : | AGOS_ACL068W (Eremothecium gossypii) | aqp-1 (Caenorhabditis elegans) | aqp-2 (Caenorhabditis elegans) | aqp-3 (Caenorhabditis elegans) | aqp-7 (Caenorhabditis elegans) | AQP9 (Bos taurus) | AQP9 (Canis lupus familiaris) | AQP9 (Gallus gallus) | AQP9 (Homo sapiens) | AQP9 (Macaca mulatta) | Aqp9 (Mus musculus) | AQP9 (Pan troglodytes) | Aqp9 (Rattus norvegicus) | aqp9a (Danio rerio) | aqp9b (Danio rerio) | NIP7;1 (Arabidopsis thaliana) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_006573 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Protein AQP-1, isoform a | Caenorhabditis elegans | Q19949 (UniProtKB/TrEMBL) | Q19949_CAEEL (UniProtKB/TrEMBL) | View | |
Protein AQP-1, isoform b | Caenorhabditis elegans | Q8IG23 (UniProtKB/TrEMBL) | Q8IG23_CAEEL (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||||
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1 | OB_007921 | Caenorhabditis elegans |
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aqp-1 expression changes in response to glucose or glycerol. Similar to daf-16 and hsf-1 mutants, aqp-1 mutants were short-lived, and their short lifespan was not further decreased by glucose. Overexpression of aqp-1::GFP rescues short lifespan of aqp-1 deletion mutants and partially prevented glucose from shortening lifespan. Glucose or glycerol feeding downregulates aqp-1 in wild-type. In daf-16 and/or hsf-1 mutants aqp-1 is repressed and glucose feeding does not significantly affect its expression. aqp-1 mutation does not further decrease the short lifespan of daf-16 and/or hsf-1 mutants. aqp-1 transgene is expressed in pharynx and intestine (which behaves as entire endoderm of animal, including adipose tissues). Dietary glucose does not cause significant differences in levels of glucose or glycerol in wild-type vs. aqp-1 mutants [ 19883616]. | 19883616 | GenDR |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
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1 | OB_008163 | 1 | The HomoloGene homology group 41405 contains 1 gene with experimental evidence for ageing relevance (aqp-1 - Caenorhabditis elegans) and 15 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 41405 |
Sequences
Q19949_CAEEL | Q19949 | Protein AQP-1, isoform a (Caenorhabditis elegans) from UniProtKB/TrEMBL Length: 304 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 Q19949_CAEEL 1 MLLRFIRKIMTAEEDTLPERLRFHGVHTNILARNLIAEFFGTFLLCFIGLSIVFQFHAGGGKTTEWIGVNIGWGFAIMFAVMATARMSGGHLNPAVSLLLWSLGHLKLAWVPLYAIAQTAGAFVASLGMYSYYYEQFNAFDGGNRTILGATGTAGCFASYPSPNLGVWGPYIDQCVGTGVLAYFLCVVIDERNQIPKIWHPMFFGFLVMMIGTGFGMNIGYPINPARDLGPRLFSYFIYGPGVFHSPYPNYWLAPAIAPFVGALVGGWFYHFSLGMHNPDIEEADDIFVQQPPKSVEQQKLLQA 304
Q8IG23_CAEEL | Q8IG23 | Protein AQP-1, isoform b (Caenorhabditis elegans) from UniProtKB/TrEMBL Length: 295 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 Q8IG23_CAEEL 1 MTAEEDTLPERLRFHGVHTNILARNLIAEFFGTFLLCFIGLSIVFQFHAGGGKTTEWIGVNIGWGFAIMFAVMATARMSGGHLNPAVSLLLWSLGHLKLAWVPLYAIAQTAGAFVASLGMYSYYYEQFNAFDGGNRTILGATGTAGCFASYPSPNLGVWGPYIDQCVGTGVLAYFLCVVIDERNQIPKIWHPMFFGFLVMMIGTGFGMNIGYPINPARDLGPRLFSYFIYGPGVFHSPYPNYWLAPAIAPFVGALVGGWFYHFSLGMHNPDIEEADDIFVQQPPKSVEQQKLLQA 295
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Lee SJ, Murphy CT, Kenyon C:
Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression.
Cell Metab. 2009; 10: 379-91.
PubMed (ID: 19883616), PubMed Central (ID: PMC2887095), doi:10.1016/j.cmet.2009.10.003
MeSH Terms: Aquaporin 1/metabolism; Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/physiology; DNA-Binding Proteins/metabolism; Glucose/metabolism; Signal Transduction; Transcription Factors/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenDR
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/TrEMBL