1 |
OB_002291 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
248.39% |
108 |
31 |
days |
max |
20 |
℃ |
hermaphrodite |
Double mutation leads to increased (250%) maximum lifespan. |
Feng et al. |
2001 |
11709184 |
|
Lifespan Observations Database (ID: 3566) |
2 |
OB_002294 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
238.09% |
71 |
21 |
days |
max |
25 |
℃ |
hermaphrodite |
Double mutation leads to increased (230%) maximum lifespan. |
Feng et al. |
2001 |
11709184 |
|
Lifespan Observations Database (ID: 3569) |
3 |
OB_002293 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
231.45% |
41.1 |
12.4 |
days |
mean |
25 |
℃ |
hermaphrodite |
Double mutation leads to increased (230%) mean lifespan. |
Feng et al. |
2001 |
11709184 |
|
Lifespan Observations Database (ID: 3568) |
4 |
OB_002688 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
RNAi knockdown |
25% RNAi |
unknown |
unknown |
nuo-6 |
Caenorhabditis elegans |
172438 |
loss of function |
qm200 |
unknown |
unknown |
|
|
|
increased |
129.63% |
49.6 |
21.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutation of nuo-6 or isp-1 appears to increase life span by a mechanism that is genetically distinct from RNAi of these genes. |
Yang et al. |
2010 |
20346072 |
doi:10.1111/j.1474-9726.2010.00571.x |
Lifespan Observations Database (ID: 3983) |
5 |
OB_002692 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
eat-2 |
Caenorhabditis elegans |
175072 |
loss of function |
ad1116 |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
120.67% |
45.9 |
20.8 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutation of nuo-6 or isp-1 appears to increase life span by a mechanism that is genetically distinct from RNAi of these genes. |
Yang et al. |
2010 |
20346072 |
doi:10.1111/j.1474-9726.2010.00571.x |
Lifespan Observations Database (ID: 3987) |
6 |
OB_002292 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
115.82% |
42.3 |
19.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Double mutation leads to increased (150%) mean lifespan. |
Feng et al. |
2001 |
11709184 |
|
Lifespan Observations Database (ID: 3567) |
7 |
OB_002286 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
103.23% |
63 |
31 |
days |
max |
20 |
℃ |
hermaphrodite |
A missense mutation leads to increased mean (60%) and maximum (100%) lifespan. Other phenotypes: Also to low oxygen consumption and decreased sensitivity to reactive oxygen species. |
Feng et al. |
2001 |
11709184 |
|
Lifespan Observations Database (ID: 3561) |
8 |
OB_005449 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
Mutation |
- |
wildtype |
yes |
|
|
|
increased |
100.00% |
|
|
|
maximum |
|
|
|
A missense mutation leads to low oxygen consumption, decreased sensitivity to reactive oxygen species, and increased mean (60%) and maximum (100%) lifespan. |
Feng et al. |
2001 |
11709184 |
|
GenAge |
9 |
OB_002696 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
nuo-6 |
Caenorhabditis elegans |
172438 |
RNAi knockdown |
50% RNAi |
unknown |
unknown |
|
|
|
increased |
93.06% |
41.7 |
21.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutation of nuo-6 or isp-1 appears to increase life span by a mechanism that is genetically distinct from RNAi of these genes. |
Yang et al. |
2010 |
20346072 |
doi:10.1111/j.1474-9726.2010.00571.x |
Lifespan Observations Database (ID: 3990) |
10 |
OB_002925 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
RNAi knockdown |
1/10 |
unknown |
unknown |
|
|
|
increased |
86.79% |
29.7 |
15.9 |
days |
mean |
30 |
℃ |
hermaphrodite |
cep-1 is required to extend longevity in response to mild suppression of several bioenergetically relevant mitochondrial proteins, including frataxin the protein defective in patients with Friedreichs Ataxia. |
Ventura et al. |
2009 |
19416129 |
doi:10.1111/j.1474-9726.2009.00482.x |
Lifespan Observations Database (ID: 4243) |
11 |
OB_002299 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
85.71% |
39 |
21 |
days |
max |
25 |
℃ |
hermaphrodite |
Mutation leads to increased (86%) maximum lifespan. |
Feng et al. |
2001 |
11709184 |
|
Lifespan Observations Database (ID: 3573) |
12 |
OB_001453 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
F48E8.3 |
Caenorhabditis elegans |
175751 |
RNAi knockdown |
- |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
unknown |
qm150 |
unknown |
unknown |
|
|
|
increased |
85.00% |
37 |
20 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi-mediated inhibition of soluble fumarate reductase differentially increases Mit mutant life span. Life-span studies were performed in duplicate and using 25 microM FuDR (n=120 worms/condition). |
Butler et al. |
2010 |
20732954 |
doi:10.1096/fj.10-162941 |
Lifespan Observations Database (ID: 2764) |
13 |
OB_002927 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cep-1 |
Caenorhabditis elegans |
172616 |
loss of function |
gk138 |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
82.39% |
29 |
15.9 |
days |
mean |
30 |
℃ |
hermaphrodite |
cep-1 is required to extend longevity in response to mild suppression of several bioenergetically relevant mitochondrial proteins, including frataxin the protein defective in patients with Friedreichs Ataxia. |
Ventura et al. |
2009 |
19416129 |
doi:10.1111/j.1474-9726.2009.00482.x |
Lifespan Observations Database (ID: 4245) |
14 |
OB_002298 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
77.42% |
22 |
12.4 |
days |
mean |
25 |
℃ |
hermaphrodite |
Mutation leads to increased (77%) mean lifespan. |
Feng et al. |
2001 |
11709184 |
|
Lifespan Observations Database (ID: 3572) |
15 |
OB_002290 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
74.19% |
54 |
31 |
days |
max |
20 |
℃ |
hermaphrodite |
Double mutation leads to increased (74%). maximum lifespan. |
Feng et al. |
2001 |
11709184 |
|
Lifespan Observations Database (ID: 3565) |
16 |
OB_002285 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
68.37% |
33 |
19.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
A missense mutation leads to increased mean (60%) and maximum (100%) lifespan. Other phenotypes: Also to low oxygen consumption and decreased sensitivity to reactive oxygen species. |
Feng et al. |
2001 |
11709184 |
|
Lifespan Observations Database (ID: 3560) |
17 |
OB_002287 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ctb-1 |
Caenorhabditis elegans |
|
loss of function |
qm189 |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
67.74% |
52 |
31 |
days |
max |
20 |
℃ |
hermaphrodite |
Double mutation leads to increased maximum lifespan (67%) . |
Feng et al. |
2001 |
11709184 |
|
Lifespan Observations Database (ID: 3562) |
18 |
OB_002288 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ctb-1 |
Caenorhabditis elegans |
|
loss of function |
qm189 |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
67.35% |
32.8 |
19.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Double mutation leads to increased mean (67%) lifespan. |
Feng et al. |
2001 |
11709184 |
|
Lifespan Observations Database (ID: 3563) |
19 |
OB_001454 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
unknown |
qm150 |
unknown |
unknown |
|
|
|
increased |
65.00% |
33 |
20 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi-mediated inhibition of soluble fumarate reductase differentially increases Mit mutant life span. Life-span studies were performed in duplicate and using 25 microM FuDR (n=120 worms/condition). |
Butler et al. |
2010 |
20732954 |
doi:10.1096/fj.10-162941 |
Lifespan Observations Database (ID: 2765) |
20 |
OB_002690 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
63.46% |
34 |
20.8 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutation of nuo-6 or isp-1 appears to increase life span by a mechanism that is genetically distinct from RNAi of these genes. |
Yang et al. |
2010 |
20346072 |
doi:10.1111/j.1474-9726.2010.00571.x |
Lifespan Observations Database (ID: 3985) |
21 |
OB_002926 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
59.12% |
25.3 |
15.9 |
days |
mean |
30 |
℃ |
hermaphrodite |
cep-1 is required to extend longevity in response to mild suppression of several bioenergetically relevant mitochondrial proteins, including frataxin the protein defective in patients with Friedreichs Ataxia. |
Ventura et al. |
2009 |
19416129 |
doi:10.1111/j.1474-9726.2009.00482.x |
Lifespan Observations Database (ID: 4244) |
22 |
OB_001670 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
rsks-1 |
Caenorhabditis elegans |
176554 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
57.29% |
30.2 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown of S6K/rsks-1 increased lifespan of isp-1(qm150) mutants by 34% relative to isp-1(qm150) mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 3002) |
23 |
OB_001669 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
rps-22 |
Caenorhabditis elegans |
175338 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
56.77% |
30.1 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of isp-1(qm150) mutants by 34% relative to isp-1(qm150) mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 3001) |
24 |
OB_002686 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
RNAi knockdown |
25% RNAi |
unknown |
unknown |
|
|
|
increased |
52.78% |
33 |
21.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutation of nuo-6 or isp-1 appears to increase life span by a mechanism that is genetically distinct from RNAi of these genes. |
Yang et al. |
2010 |
20346072 |
doi:10.1111/j.1474-9726.2010.00571.x |
Lifespan Observations Database (ID: 3981) |
25 |
OB_001135 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
F48E8.3 |
Caenorhabditis elegans |
175751 |
RNAi knockdown |
- |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
unknown |
qm150 |
unknown |
unknown |
|
|
|
increased |
52.38% |
32 |
21 |
days |
median |
20 |
℃ |
hermaphrodite |
RNAi-mediated inhibition of soluble fumarate reductase differentially increases Mit mutant life span. |
Butler et al. |
2010 |
20732954 |
doi:10.1096/fj.10-162941 |
Lifespan Observations Database (ID: 2453) |
26 |
OB_002694 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
52.31% |
32.9 |
21.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutation of nuo-6 or isp-1 appears to increase life span by a mechanism that is genetically distinct from RNAi of these genes. |
Yang et al. |
2010 |
20346072 |
doi:10.1111/j.1474-9726.2010.00571.x |
Lifespan Observations Database (ID: 3989) |
27 |
OB_001664 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
rps-15 |
Caenorhabditis elegans |
172693 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
51.56% |
29.1 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of isp-1(qm150) mutants by 21% relative to isp-1(qm150) mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 2999) |
28 |
OB_003150 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm 150 |
unknown |
unknown |
|
|
|
increased |
51.50% |
30.3 |
20 |
|
mean |
20 |
℃ |
|
Lifespan of isp-1 (qm 150) mutant increased by approximately 52% relative to N2. |
Curtis et al. |
2006 |
16626391 |
doi:10.1111/j.1474-9726.2006.00205.x |
Lifespan Observations Database (ID: 4544) |
29 |
OB_002289 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
m26 |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
51.02% |
29.6 |
19.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Double mutation leads to increased mean (50%) lifespan. |
Feng et al. |
2001 |
11709184 |
|
Lifespan Observations Database (ID: 3564) |
30 |
OB_002297 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ctb-1 |
Caenorhabditis elegans |
|
loss of function |
qm189 |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
50.81% |
18.7 |
12.4 |
days |
mean |
25 |
℃ |
hermaphrodite |
Double mutation leads to increased (50%) mean lifespan. |
Feng et al. |
2001 |
11709184 |
|
Lifespan Observations Database (ID: 3571) |
31 |
OB_001668 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
rps-15 |
Caenorhabditis elegans |
172693 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
50.00% |
28.8 |
19.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown increased lifespan of isp-1(qm150) mutants by 19% relative to isp-1(qm150) mutant lifespan. |
Hansen et al. |
2007 |
17266679 |
doi:10.1111/j.1474-9726.2006.00267.x |
Lifespan Observations Database (ID: 3000) |
32 |
OB_002296 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ctb-1 |
Caenorhabditis elegans |
|
loss of function |
qm189 |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
47.62% |
31 |
21 |
days |
max |
25 |
℃ |
hermaphrodite |
Double mutation leads to increased (47%) maximum lifespan. |
Feng et al. |
2001 |
11709184 |
|
Lifespan Observations Database (ID: 3570) |
33 |
OB_002691 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
nuo-6 |
Caenorhabditis elegans |
172438 |
loss of function |
qm200 |
unknown |
unknown |
|
|
|
increased |
45.19% |
30.2 |
20.8 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutation of nuo-6 or isp-1 appears to increase life span by a mechanism that is genetically distinct from RNAi of these genes. |
Yang et al. |
2010 |
20346072 |
doi:10.1111/j.1474-9726.2010.00571.x |
Lifespan Observations Database (ID: 3986) |
34 |
OB_002924 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
cep-1 |
Caenorhabditis elegans |
172616 |
loss of function |
gk138 |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
RNAi knockdown |
1/10 |
unknown |
unknown |
|
|
|
increased |
42.77% |
22.7 |
15.9 |
days |
mean |
30 |
℃ |
hermaphrodite |
cep-1 is required to extend longevity in response to mild suppression of several bioenergetically relevant mitochondrial proteins, including frataxin the protein defective in patients with Friedreichs Ataxia. |
Ventura et al. |
2009 |
19416129 |
doi:10.1111/j.1474-9726.2009.00482.x |
Lifespan Observations Database (ID: 4242) |
35 |
OB_001136 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
unknown |
qm150 |
unknown |
unknown |
|
|
|
increased |
23.81% |
26 |
21 |
days |
median |
20 |
℃ |
hermaphrodite |
RNAi-mediated inhibition of soluble fumarate reductase differentially increases Mit mutant life span. |
Butler et al. |
2010 |
20732954 |
doi:10.1096/fj.10-162941 |
Lifespan Observations Database (ID: 2454) |
36 |
OB_002651 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Valproic acid |
0.6 |
mM |
|
|
increased |
21.60% |
19.7 |
16.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
The mood stabilizer and anticonvulsant valproic acid (VA) extended C. elegans lifespan. |
Evason et al. |
2008 |
18248662 |
doi:10.1111/j.1474-9726.2008.00375.x |
Lifespan Observations Database (ID: 3943) |
37 |
OB_003151 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
aak-2 |
Caenorhabditis elegans |
181727 |
loss of function |
ok524 |
unknown |
unknown |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm 150 |
unknown |
unknown |
|
|
|
increased |
13.00% |
22.6 |
20 |
|
mean |
20 |
℃ |
|
Lifespan of double mutant isp-1 (qm 150); aak-2(ok524) increased by approximately 13% relative to N2. |
Curtis et al. |
2006 |
16626391 |
doi:10.1111/j.1474-9726.2006.00205.x |
Lifespan Observations Database (ID: 4545) |
38 |
OB_002650 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
|
|
increased |
10.49% |
17.9 |
16.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
The mood stabilizer and anticonvulsant valproic acid (VA) extended C. elegans lifespan. |
Evason et al. |
2008 |
18248662 |
doi:10.1111/j.1474-9726.2008.00375.x |
Lifespan Observations Database (ID: 3942) |
39 |
OB_002653 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Valproic acid |
6 |
mM |
|
|
none |
-4.32% |
15.5 |
16.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
The mood stabilizer and anticonvulsant valproic acid (VA) extended C. elegans lifespan. |
Evason et al. |
2008 |
18248662 |
doi:10.1111/j.1474-9726.2008.00375.x |
Lifespan Observations Database (ID: 3945) |
40 |
OB_002652 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
isp-1 |
Caenorhabditis elegans |
177609 |
loss of function |
qm150 |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Valproic acid |
3 |
mM |
|
|
decreased |
-6.17% |
15.2 |
16.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
The mood stabilizer and anticonvulsant valproic acid (VA) extended C. elegans lifespan. |
Evason et al. |
2008 |
18248662 |
doi:10.1111/j.1474-9726.2008.00375.x |
Lifespan Observations Database (ID: 3944) |