Gene: hus-1 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | hus-1 | ||||||||||||||||||||||||||||
NCBI Gene ID | : | 171939 | ||||||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||||||
Gene Synonyms | : | CELE_H26D21.1 | hus-1 | Protein HUS-1 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP011361 (Anopheles gambiae) | hus-1 (Caenorhabditis elegans) | HUS1 (Canis lupus familiaris) | HUS1 (Gallus gallus) | HUS1 (Homo sapiens) | HUS1 (Macaca mulatta) | Hus1 (Mus musculus) | HUS1 (Pan troglodytes) | Hus1 (Rattus norvegicus) | hus1 (Schizosaccharomyces pombe) | Hus1-like (Drosophila melanogaster) | MGG_12138 (Magnaporthe oryzae) | NCU11262 (Neurospora crassa) | zgc:162895 (Danio rerio) | ||||||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_006782 | ||||||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Hus1-like protein | Caenorhabditis elegans | G5EFI9 (UniProtKB/TrEMBL) | G5EFI9_CAEEL (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_005397 | Caenorhabditis elegans |
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RNA interference increased mean lifespan by 11%. In hus-1 mutants, RNA interference of cep-1 did not increase lifespan, suggesting both genes influence lifespan through the same pathway. | 17895432 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_003828 | Caenorhabditis elegans |
|
increased | 11.00% | RNA interference increased mean lifespan by 11%. | Arum et al. | 2007 | 17895432 | Lifespan Observations Database (ID: 551) | |||||||||||||||||||||||||
2 | OB_005398 | Caenorhabditis elegans |
|
increased | 11.00% | Average | RNA interference increased mean lifespan by 11%. In hus-1 mutants, RNA interference of cep-1 did not increase lifespan, suggesting both genes influence lifespan through the same pathway. | Arum et al. | 2007 | 17895432 | GenAge | ||||||||||||||||||||||||
3 | OB_003829 | Caenorhabditis elegans |
|
none | In hus-1 mutants, RNA interference of cep-1 did not increase lifespan, Other phenotypes: Suggests that both genes influence lifespan through the same pathway. | Arum et al. | 2007 | 17895432 | Lifespan Observations Database (ID: 552) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_009115 | 1 | The HomoloGene homology group 37932 contains 1 gene with experimental evidence for ageing relevance (hus-1 - Caenorhabditis elegans) and 13 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 37932 |
Sequences
G5EFI9_CAEEL | G5EFI9 | Hus1-like protein (Caenorhabditis elegans) from UniProtKB/TrEMBL Length: 277 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 G5EFI9_CAEEL 1 MKFSSLLQDTAAIDVFIKILTSVSKLSKKRCCVKIEKNALNFICCSGLHDGGSWFSLSIPYSSQIFRKFDMVGMNPRNEEQNLIYFELEIDSLVRVLPGGHCYLKLKLSKSQKDEPMLSVEVRNPEADIVSHQIPITIILSKYWNSYSRPSIGHRKMSISMPPPKMMSRFLHVFKNMNTRVVKLTASTSGDLRISTKIETGEIDVSFSDLQTNPSETDSQEDTAKVQLMIRNISPLFQSFANTRTRAKMNIISNRMAEFNFHNEDCVLSYIVGNVSD 277
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Arum O, Johnson TE:
Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity.
J Gerontol A Biol Sci Med Sci. 2007; 62: 951-9.
PubMed (ID: 17895432)
MeSH Terms: Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans/genetics; Genes, Helminth; Longevity/genetics; Tumor Suppressor Protein p53/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- UniProtKB/TrEMBL
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed