Gene: ifg-1 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | ifg-1 | ||||||||||||||||||||||||
NCBI Gene ID | : | 174322 | ||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||
Gene Synonyms | : | CELE_M110.4 | ifg-1 | Protein IFG-1 Source: GPSDB |
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Gene Homologs | : | ifg-1 (Caenorhabditis elegans) | LOC100333590 (Danio rerio) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_006862 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Protein IFG-1, isoform c | Caenorhabditis elegans | B5BM23 (UniProtKB/TrEMBL) | B5BM23_CAEEL (UniProtKB/TrEMBL) | View | |
Protein IFG-1, isoform d | Caenorhabditis elegans | B5BM24 (UniProtKB/TrEMBL) | B5BM24_CAEEL (UniProtKB/TrEMBL) | View | |
Protein IFG-1, isoform e | Caenorhabditis elegans | B5BM25 (UniProtKB/TrEMBL) | B5BM25_CAEEL (UniProtKB/TrEMBL) | View | |
Protein IFG-1, isoform a | Caenorhabditis elegans | Q21531 (UniProtKB/TrEMBL) | Q21531_CAEEL (UniProtKB/TrEMBL) | View | |
Protein IFG-1, isoform b | Caenorhabditis elegans | Q7JMF0 (UniProtKB/TrEMBL) | Q7JMF0_CAEEL (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_005413 | Caenorhabditis elegans |
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RNAi increased maximum lifespan by about 30%. Reducing the levels of eIF2β or eIF4G did not extend the lifespan of daf-16 mutants at all. eIF2β and eIF4G RNAi slightly shortened the lifespan of daf-2 mutants. sir-2.1 deletion mutant was subjected to sir-2.1(ok434), to RP, S6K, TOR or eIF RNAi - In each case, lifespan was extended. | 17266679 | GenAge | |||||
2 | OB_005415 | Caenorhabditis elegans |
|
Inhibition of ifg-1 during adulthood led to a 36% increase in maximum lifespan. Inhibition of at least one eIF4E isoform and two of the three poly(A)-binding proteins also has a significant effect on lifespan extension. Inhibition of let-363 increased lifespan in both the N2 background and when ifg-1 was inhibited. In the daf-2 (e1370) mutant background, inhibition of either ifg-1 or rsks-1 further extended lifespan by 70% and 24%, respectively. Inhibition of either ifg-1 or rsks-1 extended lifespan by 27% and 14%, respectively, in a daf-16 (mu86 ) background. Inhibition of either ifg-1 or rsks-1 in the clk-1(e2519) mutant background led to a further lifespan extension by 19% and 13%, respectively. Inhibition of either ifg-1 or rsks-1 extended lifespan in the eat-2 background by 54% and 11%, respectively. In a sir-2.1 mutant background, ifg-1 inhibition extended lifespan by 93% and rsks-1 inhibition by 33%. | 17266680 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||||||||||||||||
1 | OB_001555 | Caenorhabditis elegans | N2 |
|
increased | 72.40% | 33.1 | 19.2 | days | mean | 20 | ℃ | hermaphrodite | For calculating relative effect of lifespan in mutant background, an average of all N2 data in Table I was used since no experiment matched control was provided. RNA knockdown extended lifespan of fer-15;fem-1 mutants by 48% relative to fer-15;fem-1 mutant lifespan.. | Hansen et al. | 2007 | 17266679 | doi:10.1111/j.1474-9726.2006.00267.x | Lifespan Observations Database (ID: 2896) | ||||||||||||||||||||||||||||||
2 | OB_001641 | Caenorhabditis elegans | N2 |
|
increased | 71.35% | 32.9 | 19.2 | days | mean | 20 | ℃ | hermaphrodite | For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown of eIF4G/ifg-1 extended lifespan of eat-2(ad1116) mutants by 29% relative to eat-2(ad1116) mutant lifespan. | Hansen et al. | 2007 | 17266679 | doi:10.1111/j.1474-9726.2006.00267.x | Lifespan Observations Database (ID: 2978) | ||||||||||||||||||||||||||||||
3 | OB_005417 | Caenorhabditis elegans |
|
increased | 55.00% | Average | RNA interference in adulthood resulted in a 55% mean lifespan extension. | Curran et al. | 2007 | 17411345 | doi:10.1371/journal.pgen.0030056 | GenAge | |||||||||||||||||||||||||||||||||||||
4 | OB_001642 | Caenorhabditis elegans | N2 |
|
increased | 53.65% | 29.5 | 19.2 | days | mean | 20 | ℃ | hermaphrodite | For calculating relative effect of lifespan in mutant background, an average of N2 data in Table I was used since no experiment matched control was provided. RNA knockdown of eIF4G/ifg-1 extended lifespan of eat-2(ad1116) mutants by 17% relative to eat-2(ad1116) mutant lifespan. | Hansen et al. | 2007 | 17266679 | doi:10.1111/j.1474-9726.2006.00267.x | Lifespan Observations Database (ID: 2979) | ||||||||||||||||||||||||||||||
5 | OB_001556 | Caenorhabditis elegans | N2 |
|
increased | 48.44% | 28.5 | 19.2 | days | mean | 20 | ℃ | hermaphrodite | For calculating relative effect of lifespan in mutant background, an average of all N2 data in Table I was used since no experiment matched control was provided. RNA knockdown extended lifespan of fer-15;fem-1 mutants by 30% relative to fer-15;fem-1 mutant lifespan.. | Hansen et al. | 2007 | 17266679 | doi:10.1111/j.1474-9726.2006.00267.x | Lifespan Observations Database (ID: 2897) | ||||||||||||||||||||||||||||||
6 | OB_005416 | Caenorhabditis elegans |
|
increased | 36.00% | maximum | Inhibition of ifg-1 during adulthood led to a 36% increase in maximum lifespan. Inhibition of at least one eIF4E isoform and two of the three poly(A)-binding proteins also has a significant effect on lifespan extension. Inhibition of let-363 increased lifespan in both the N2 background and when ifg-1 was inhibited. In the daf-2 (e1370) mutant background, inhibition of either ifg-1 or rsks-1 further extended lifespan by 70% and 24%, respectively. Inhibition of either ifg-1 or rsks-1 extended lifespan by 27% and 14%, respectively, in a daf-16 (mu86 ) background. Inhibition of either ifg-1 or rsks-1 in the clk-1(e2519) mutant background led to a further lifespan extension by 19% and 13%, respectively. Inhibition of either ifg-1 or rsks-1 extended lifespan in the eat-2 background by 54% and 11%, respectively. In a sir-2.1 mutant background, ifg-1 inhibition extended lifespan by 93% and rsks-1 inhibition by 33%. | Pan et al. | 2007 | 17266680 | doi:10.1111/j.1474-9726.2006.00266.x | GenAge | |||||||||||||||||||||||||||||||||||||
7 | OB_005414 | Caenorhabditis elegans |
|
increased | 30.00% | maximum | RNAi increased maximum lifespan by about 30%. Reducing the levels of eIF2β or eIF4G did not extend the lifespan of daf-16 mutants at all. eIF2β and eIF4G RNAi slightly shortened the lifespan of daf-2 mutants. sir-2.1 deletion mutant was subjected to sir-2.1(ok434), to RP, S6K, TOR or eIF RNAi - In each case, lifespan was extended. | Hansen et al. | 2007 | 17266679 | doi:10.1111/j.1474-9726.2006.00267.x | GenAge | |||||||||||||||||||||||||||||||||||||
8 | OB_005418 | Caenorhabditis elegans |
|
increased | 30.00% | maximum | RNAi resulted in a 30% maximum lifespan extension compared to wild-type. | Wang et al. | 2010 | 20700440 | doi:10.1371/journal.pgen.1001048 | GenAge | |||||||||||||||||||||||||||||||||||||
9 | OB_001557 | Caenorhabditis elegans | N2 |
|
increased | 29.69% | 24.9 | 19.2 | days | mean | 20 | ℃ | hermaphrodite | For calculating relative effect of lifespan in mutant background, an average of all N2 data in Table I was used since no experiment matched control was provided. RNA knockdown extended lifespan of fer-15;fem-1 mutants by 9% relative to fer-15;fem-1 mutant lifespan.. | Hansen et al. | 2007 | 17266679 | doi:10.1111/j.1474-9726.2006.00267.x | Lifespan Observations Database (ID: 2898) | ||||||||||||||||||||||||||||||
10 | OB_005412 | Caenorhabditis elegans |
|
increased | unknown | Post developmental RNAi resulted in a mean and maximum lifespan daf-16 dependent extension. | Henderson et al. | 2006 | 16720740 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_008306 |
|
1 | The HomoloGene homology group 123899 contains 1 gene with experimental evidence for ageing relevance (ifg-1 - Caenorhabditis elegans) and 1 other gene. | AgeFactDB Homology Analysis | HomoloGene homology group 123899 |
Sequences
B5BM23_CAEEL | B5BM23 | Protein IFG-1, isoform c (Caenorhabditis elegans) from UniProtKB/TrEMBL Length: 1042 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 B5BM23_CAEEL 1 MPYQPAQPAQQQMTHTAPQEPKRQRKALEIVDPTTKKAIEVTPHLAPAAPAPAAPAAPIAPEEEKKKQNITLEFLNQVKNELHHEDRRHDNPPAVPAAVPAAVQAAVLPNFSVPPPALGQTPPAASIAPQVVPSVPKTPEAPAKADYEVKQAETLVTPVSSPHASDTTTTTPASGTAESASTVADVRVTPTLTKEESKEETDDDKFEENDERESTPDVADSSTEKTPEELEIEKAQKEAEEIEKKKLREEALEKRIEELILAGSAVISDGTFGRDFMVTIREIEKVFSRTPCPLSPAQLADFGLDIKTMRVSDNKKPNFTPNWANKGGNRQQVPYRGRTTTDGTGRGGQQQRDRMHNKRPPVVRPSIERVQRVTLPSSKDAWKPDRQKTAEAVASEEAAVIEVCKKVRSLMNKVTPTSQRPLTEEFISYNVSSNDAQLAQVVEIVFDKAVEEPKFCALYAEMCKAQANHELSQTGGKSAFRNKVLTRTQMTFQDKKDIDADKLAIIEKEEDPVKKELMLAEEKQKFRRRKFGVMTFMGYLYRNQLLSTKIVQTCTFELFNSIKDQDIKKEDVDEESIHCGLQLIETVGVMLDKSKDSTTVFLDQWFQKLEAAKPYCSNKIRFMIMNLMELRKDKWIPRKSTESGPKKIDEIHKDIRQEKIENEKARDQYDRDRDRRHGGVRPNSNSLRKSVPVSRNSLDRNRGMQHPEQKRAAAAANTKLASSSVQPKNISLSSMDNNTLGKSKKEWHSGASGGGNTSSESAVPVKSAWGRRDSNDQRKKSTVDEKQAALAAAKEISAMSISSRRSTSQNSNTDKTDDELTEEEKAVRAKIMNTVKSDLLEMSSGELSQKELVDSITDYVGKEKYGSPSLTVVYEMIIRAVIEKGLKDDDRKKLAIALRMSLVSKTEKQAFIEGATRFCKFANDVELQQDYPKLWTVTGEVLVNTSHAPHDEIGEVESFSLADMKPIFSAAKGEGNKKFDLLVQVLKQLIELELEVTGAAEGISWEFSDMKLKTEMEEGLSAEMEAVTFKNGKTLSSYLTGN 1042
B5BM24_CAEEL | B5BM24 | Protein IFG-1, isoform d (Caenorhabditis elegans) from UniProtKB/TrEMBL Length: 734 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 B5BM24_CAEEL 1 MRVSDNKKPNFTPNWANKGGNRQQVPYRGRTTTDGTGRGGQQQRDRMHNKRPPVVRPSIERVQRVTLPSSKDAWKPDRQKTAEAVASEEAAVIEVCKKVRSLMNKVTPTSQRPLTEEFISYNVSSNDAQLAQVVEIVFDKAVEEPKFCALYAEMCKAQANHELSQTGGKSAFRNKVLTRTQMTFQDKKDIDADKLAIIEKEEDPVKKELMLAEEKQKFRRRKFGVMTFMGYLYRNQLLSTKIVQTCTFELFNSIKDQDIKKEDVDEESIHCGLQLIETVGVMLDKSKDSTTVFLDQWFQKLEAAKPYCSNKIRFMIMNLMELRKDKWIPRKSTESGPKKIDEIHKDIRQEKIENEKARDQYDRDRDRRHGGVRPNSNSLRKSVPVSRNSLDRNRGMQHPEQKRAAAAANTKLASSSVQPKNISLSSMDNNTLGKSKKEWHSGASGGGNTSSESAVPVKSAWGRRDSNDQRKKSTVDEKQAALAAAKEISAMSISSRRSTSQNSNTDKTDDELTEEEKAVRAKIMNTVKSDLLEMSSGELSQKELVDSITDYVGKEKYGSPSLTVVYEMIIRAVIEKGLKDDDRKKLAIALRMSLVSKTEKQAFIEGATRFCKFANDVELQQDYPKLWTVTGEVLVNTSHAPHDEIGEVESFSLADMKPIFSAAKGEGNKKFDLLVQVLKQLIELELEVTGAAEGISWEFSDMKLKTEMEEGLSAEMEAVTFKNGKTLSSYLTGN 734
B5BM25_CAEEL | B5BM25 | Protein IFG-1, isoform e (Caenorhabditis elegans) from UniProtKB/TrEMBL Length: 688 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 B5BM25_CAEEL 1 MHNKRPPVVRPSIERVQRVTLPSSKDAWKPDRQKTAEAVASEEAAVIEVCKKVRSLMNKVTPTSQRPLTEEFISYNVSSNDAQLAQVVEIVFDKAVEEPKFCALYAEMCKAQANHELSQTGGKSAFRNKVLTRTQMTFQDKKDIDADKLAIIEKEEDPVKKELMLAEEKQKFRRRKFGVMTFMGYLYRNQLLSTKIVQTCTFELFNSIKDQDIKKEDVDEESIHCGLQLIETVGVMLDKSKDSTTVFLDQWFQKLEAAKPYCSNKIRFMIMNLMELRKDKWIPRKSTESGPKKIDEIHKDIRQEKIENEKARDQYDRDRDRRHGGVRPNSNSLRKSVPVSRNSLDRNRGMQHPEQKRAAAAANTKLASSSVQPKNISLSSMDNNTLGKSKKEWHSGASGGGNTSSESAVPVKSAWGRRDSNDQRKKSTVDEKQAALAAAKEISAMSISSRRSTSQNSNTDKTDDELTEEEKAVRAKIMNTVKSDLLEMSSGELSQKELVDSITDYVGKEKYGSPSLTVVYEMIIRAVIEKGLKDDDRKKLAIALRMSLVSKTEKQAFIEGATRFCKFANDVELQQDYPKLWTVTGEVLVNTSHAPHDEIGEVESFSLADMKPIFSAAKGEGNKKFDLLVQVLKQLIELELEVTGAAEGISWEFSDMKLKTEMEEGLSAEMEAVTFKNGKTLSSYLTGN 688
Q21531_CAEEL | Q21531 | Protein IFG-1, isoform a (Caenorhabditis elegans) from UniProtKB/TrEMBL Length: 1156 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 1150 Q21531_CAEEL 1 MSNAVSRGPGRGKPNQDHNAVPMQDSSQQFVMPFVNTSGPVNSNYQRMPMNQSAYPQYGQQQYNQPQTNHYYPPQAPQHQQQYGGYQRPDYGHQPQMYNQQYQGYQAPQQYHPEMPYQPAQPAQQQMTHTAPQEPKRQRKALEIVDPTTKKAIEVTPHLAPAAPAPAAPAAPIAPEEEKKKQNITLEFLNQVKNELHHEDRRHDNPPAVPAAVPAAVQAAVLPNFSVPPPALGQTPPAASIAPQVVPSVPKTPEAPAKADYEVKQAETLVTPVSSPHASDTTTTTPASGTAESASTVADVRVTPTLTKEESKEETDDDKFEENDERESTPDVADSSTEKTPEELEIEKAQKEAEEIEKKKLREEALEKRIEELILAGSAVISDGTFGRDFMVTIREIEKVFSRTPCPLSPAQLADFGLDIKTMRVSDNKKPNFTPNWANKGGNRQQVPYRGRTTTDGTGRGGQQQRDRMHNKRPPVVRPSIERVQRVTLPSSKDAWKPDRQKTAEAVASEEAAVIEVCKKVRSLMNKVTPTSQRPLTEEFISYNVSSNDAQLAQVVEIVFDKAVEEPKFCALYAEMCKAQANHELSQTGGKSAFRNKVLTRTQMTFQDKKDIDADKLAIIEKEEDPVKKELMLAEEKQKFRRRKFGVMTFMGYLYRNQLLSTKIVQTCTFELFNSIKDQDIKKEDVDEESIHCGLQLIETVGVMLDKSKDSTTVFLDQWFQKLEAAKPYCSNKIRFMIMNLMELRKDKWIPRKSTESGPKKIDEIHKDIRQEKIENEKARDQYDRDRDRRHGGVRPNSNSLRKSVPVSRNSLDRNRGMQHPEQKRAAAAANTKLASSSVQPKNISLSSMDNNTLGKSKKEWHSGASGGGNTSSESAVPVKSAWGRRDSNDQRKKSTVDEKQAALAAAKEISAMSISSRRSTSQNSNTDKTDDELTEEEKAVRAKIMNTVKSDLLEMSSGELSQKELVDSITDYVGKEKYGSPSLTVVYEMIIRAVIEKGLKDDDRKKLAIALRMSLVSKTEKQAFIEGATRFCKFANDVELQQDYPKLWTVTGEVLVNTSHAPHDEIGEVESFSLADMKPIFSAAKGEGNKKFDLLVQVLKQLIELELEVTGAAEGISWEFSDMKLKTEMEEGLSAEMEAVTFKNGKTLSSYLTGN 1156
Q7JMF0_CAEEL | Q7JMF0 | Protein IFG-1, isoform b (Caenorhabditis elegans) from UniProtKB/TrEMBL Length: 1155 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 1150 Q7JMF0_CAEEL 1 MSNAVSRGPGRGKPNQDHNAVPMQDSSQQFVMPFVNTSGPVNSNYQRMPMNQSAYPQYGQQQYNQPQTNHYYPPQAPQHQQQYGGYQRPDYGHQPQMYNQQYQGYQAPQQYHPEMPYQPAQPAQQQMTHTAPQEPKRQRKALEIVDPTTKKAIEVTPHLAPAAPAPAAPAAPIAPEEEKKKQNITLEFLNQVKNELHHEDRRHDNPPAVPAAVPAAVQAAVLPNFSVPPPALGQTPPAASIAPQVVPSVPKTPEAPAKADYEVKQAETLVTPVSSPHASDTTTTTPASGTAESASTVADVRVTPTLTKEESKEETDDDKFEENDERESTPDVADSSTEKTPEELEIEKAQKEAEEIEKKKLREEALEKRIEELILAGSAVISDGTFGRDFMVTIREIEKVFSRTPCPLSPAQLADFGLDIKTMRVSDNKKPNFTPNWANKGGNRQQPYRGRTTTDGTGRGGQQQRDRMHNKRPPVVRPSIERVQRVTLPSSKDAWKPDRQKTAEAVASEEAAVIEVCKKVRSLMNKVTPTSQRPLTEEFISYNVSSNDAQLAQVVEIVFDKAVEEPKFCALYAEMCKAQANHELSQTGGKSAFRNKVLTRTQMTFQDKKDIDADKLAIIEKEEDPVKKELMLAEEKQKFRRRKFGVMTFMGYLYRNQLLSTKIVQTCTFELFNSIKDQDIKKEDVDEESIHCGLQLIETVGVMLDKSKDSTTVFLDQWFQKLEAAKPYCSNKIRFMIMNLMELRKDKWIPRKSTESGPKKIDEIHKDIRQEKIENEKARDQYDRDRDRRHGGVRPNSNSLRKSVPVSRNSLDRNRGMQHPEQKRAAAAANTKLASSSVQPKNISLSSMDNNTLGKSKKEWHSGASGGGNTSSESAVPVKSAWGRRDSNDQRKKSTVDEKQAALAAAKEISAMSISSRRSTSQNSNTDKTDDELTEEEKAVRAKIMNTVKSDLLEMSSGELSQKELVDSITDYVGKEKYGSPSLTVVYEMIIRAVIEKGLKDDDRKKLAIALRMSLVSKTEKQAFIEGATRFCKFANDVELQQDYPKLWTVTGEVLVNTSHAPHDEIGEVESFSLADMKPIFSAAKGEGNKKFDLLVQVLKQLIELELEVTGAAEGISWEFSDMKLKTEMEEGLSAEMEAVTFKNGKTLSSYLTGN 1155
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Henderson ST, Bonafè M, Johnson TE:
daf-16 protects the nematode Caenorhabditis elegans during food deprivation.
J Gerontol A Biol Sci Med Sci. 2006; 61: 444-60.
PubMed (ID: 16720740)
MeSH Terms: Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/physiology; Food Deprivation; Reactive Oxygen Species/metabolism; Transcription Factors/metabolism - Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, Kenyon C:
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans.
Aging Cell. 2007; 6: 95-110.
PubMed (ID: 17266679), doi:10.1111/j.1474-9726.2006.00267.x
MeSH Terms: Caenorhabditis elegans/genetics; Caenorhabditis elegans/metabolism; Gene Expression Regulation/genetics; Longevity/genetics; Protein Biosynthesis/genetics; Saccharomyces cerevisiae Proteins/metabolism - Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, Lithgow GJ, Kapahi P:
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans.
Aging Cell. 2007; 6: 111-9.
PubMed (ID: 17266680), PubMed Central (ID: PMC2745345), doi:10.1111/j.1474-9726.2006.00266.x
MeSH Terms: Caenorhabditis elegans Proteins/biosynthesis; Caenorhabditis elegans/genetics; Caenorhabditis elegans/metabolism; Gene Expression Regulation, Developmental/genetics; Longevity/genetics; Protein Biosynthesis/genetics; Ribosomal Protein S6 Kinases, 70-kDa/biosynthesis - Curran SP, Ruvkun G:
Lifespan regulation by evolutionarily conserved genes essential for viability.
PLoS Genet. 2007; 3: e56.
PubMed (ID: 17411345), PubMed Central (ID: PMC1847696), doi:10.1371/journal.pgen.0030056
MeSH Terms: Caenorhabditis elegans/genetics; Caenorhabditis elegans/physiology; Conserved Sequence/genetics; Evolution, Molecular; Genes, Essential; Genes, Helminth; Longevity/genetics - Wang J, Robida-Stubbs S, Tullet JM, Rual JF, Vidal M, Blackwell TK:
RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition.
PLoS Genet. 2010; 6:
PubMed (ID: 20700440), PubMed Central (ID: PMC2916858), doi:10.1371/journal.pgen.1001048
MeSH Terms: Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/physiology; DNA-Binding Proteins/metabolism; Longevity; Protein Biosynthesis; RNA Interference; Transcription Factors/metabolism; Transcription, Genetic
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/TrEMBL