Gene: mnk-1 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | mnk-1 | ||||||||||||||||||||||||||||
NCBI Gene ID | : | 174623 | ||||||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||||||
Gene Synonyms | : | CELE_R166.5 | mnk-1 | Protein MNK-1 Source: GPSDB |
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Gene Homologs | : | MKNK1 (Bos taurus) | MKNK1 (Canis lupus familiaris) | mknk1 (Danio rerio) | MKNK1 (Gallus gallus) | MKNK1 (Homo sapiens) | MKNK1 (Macaca mulatta) | Mknk1 (Mus musculus) | MKNK1 (Pan troglodytes) | Mknk1 (Rattus norvegicus) | mnk-1 (Caenorhabditis elegans) | ||||||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_006922 | ||||||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Protein MNK-1, isoform a | Caenorhabditis elegans | Q22005 (UniProtKB/TrEMBL) | Q22005_CAEEL (UniProtKB/TrEMBL) | View | |
Protein MNK-1, isoform b | Caenorhabditis elegans | Q8I113 (UniProtKB/TrEMBL) | Q8I113_CAEEL (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_005565 | Caenorhabditis elegans |
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RNA interference shortened wild-type (20%) and ife-2 mutant (15%) maximum lifespan. | 17277769 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_003877 | Caenorhabditis elegans |
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increased | 20.00% | RNA interference shortened wild-type lifespan (20%). | Syntichaki et al. | 2007 | 17277769 | doi:10.1038/nature05603 | Lifespan Observations Database (ID: 596) | ||||||||||||||||||||||||
2 | OB_003878 | Caenorhabditis elegans |
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increased | 15.00% | RNA interference shortened ife-2 mutant (15%) maximum lifespan. | Syntichaki et al. | 2007 | 17277769 | doi:10.1038/nature05603 | Lifespan Observations Database (ID: 597) | ||||||||||||||||||||||||
3 | OB_004233 | Caenorhabditis elegans | N2 |
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none | 2.00% | days | mean | 20 | ℃ | hermaphrodite | RNAi knockdown of mnk-1 had no significant effect on life span of N2 animals. | Okuyama et al. | 2010 | 20624915 | doi:10.1074/jbc.M110.146274 | Lifespan Observations Database (ID: 926) | ||||||||||||||||||
4 | OB_005566 | Caenorhabditis elegans |
|
decreased | -20.00% | maximum | RNA interference shortened wild-type (20%) and ife-2 mutant (15%) maximum lifespan. | Syntichaki et al. | 2007 | 17277769 | doi:10.1038/nature05603 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_009189 | 1 | The HomoloGene homology group 37838 contains 1 gene with experimental evidence for ageing relevance (mnk-1 - Caenorhabditis elegans) and 9 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 37838 |
Sequences
Q22005_CAEEL | Q22005 | Protein MNK-1, isoform a (Caenorhabditis elegans) from UniProtKB/TrEMBL Length: 705 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 Q22005_CAEEL 1 MTILHAGYPQSPVVHFGRHHNVNINQLNLNHLGQVDNIPNNSAVGGGGAAFHHLHTSAATPRHVATSEFYDDEEATSPRGGIEIGAGGGKMMANLRRHRQRERETYEDEDVLSSSDESSGRPIPRYVGRDTDHVFGEFEMDDEDVVMRREDGYGEDETDEDYFDEEEPVAELLPLGGGTRRVPRTPGRKNSSKCGFFDYYKLTDEHLGSGAYGSVTTCKSIKSGVEYAVKIVDKQGETHSRKRILREVNIFKTCKDHPNIVQLLDWFEDETNFYLVMEKMRGGPLLQHILQRKYFTEEEARRVTKDISLALKFMHDRGIAHRDVKPENVLCTDPNHVSPVKLCDLDLASQRPPQHERHPLSQVASEPDLASPVGSAEFMAPEVVDAYVGDSLKYDKKCDTWSLGVILYIMLAGYAPFQGMCDDEDCGWSEGKPCEDCQQDLFHRIQDGYYEFPEEEWGMISEEAKDLVSNLLKRDPVDRFNADQILSHRWLQQSAASTILQTPSNLINRKDSARDVQQMSEHFNLMNRLADTRLSARFDNKMTMSECGSDLGTATIHGDGSFLSMGGEPFGTFPRKKSVGIAIEKSRSGEFTPPISRASPTTPPPSMLNLSEDLTDSPVKRRSADDSGTFSLFSPASSNGDDSICSPPMVFVDMPSIQLFGTGALLTSVQMTPRHTTEDDASLKSFEDEQENANPIHRIETQVNV 705
Q8I113_CAEEL | Q8I113 | Protein MNK-1, isoform b (Caenorhabditis elegans) from UniProtKB/TrEMBL Length: 707 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 Q8I113_CAEEL 1 MFFLDNTDSMTSSSRGITMPNTISSHEDVGGYSPRKVGIQHDYSAVGGGGAAFHHLHTSAATPRHVATSEFYDDEEATSPRGGIEIGAGGGKMMANLRRHRQRERETYEDEDVLSSSDESSGRPIPRYVGRDTDHVFGEFEMDDEDVVMRREDGYGEDETDEDYFDEEEPVAELLPLGGGTRRVPRTPGRKNSSKCGFFDYYKLTDEHLGSGAYGSVTTCKSIKSGVEYAVKIVDKQGETHSRKRILREVNIFKTCKDHPNIVQLLDWFEDETNFYLVMEKMRGGPLLQHILQRKYFTEEEARRVTKDISLALKFMHDRGIAHRDVKPENVLCTDPNHVSPVKLCDLDLASQRPPQHERHPLSQVASEPDLASPVGSAEFMAPEVVDAYVGDSLKYDKKCDTWSLGVILYIMLAGYAPFQGMCDDEDCGWSEGKPCEDCQQDLFHRIQDGYYEFPEEEWGMISEEAKDLVSNLLKRDPVDRFNADQILSHRWLQQSAASTILQTPSNLINRKDSARDVQQMSEHFNLMNRLADTRLSARFDNKMTMSECGSDLGTATIHGDGSFLSMGGEPFGTFPRKKSVGIAIEKSRSGEFTPPISRASPTTPPPSMLNLSEDLTDSPVKRRSADDSGTFSLFSPASSNGDDSICSPPMVFVDMPSIQLFGTGALLTSVQMTPRHTTEDDASLKSFEDEQENANPIHRIETQVNV 707
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Syntichaki P, Troulinaki K, Tavernarakis N:
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans.
Nature. 2007; 445: 922-6.
PubMed (ID: 17277769), doi:10.1038/nature05603
MeSH Terms: Aging/physiology; Caenorhabditis elegans/cytology; Caenorhabditis elegans/physiology; Eukaryotic Initiation Factor-4E/metabolism; Longevity/physiology - Okuyama T, Inoue H, Ookuma S, Satoh T, Kano K, Honjoh S, Hisamoto N, Matsumoto K, Nishida E:
The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans.
J Biol Chem. 2010; 285: 30274-81.
PubMed (ID: 20624915), PubMed Central (ID: PMC2943277), doi:10.1074/jbc.M110.146274
MeSH Terms: Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/metabolism; DNA-Binding Proteins/metabolism; Longevity/physiology; MAP Kinase Signaling System/physiology; Receptor, Insulin/metabolism; Transcription Factors/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- UniProtKB/TrEMBL
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed