Gene: bec-1 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
bec-1 |
NCBI Gene ID |
: |
177345 |
Species |
: |
Caenorhabditis elegans |
Gene Synonyms |
: |
bec-1 | CELE_T19E7.3 | Protein BEC-1
Source: GPSDB |
Gene Homologs |
: |
AgaP_AGAP003858 (Anopheles gambiae) | AGOS_ACR154W (Eremothecium gossypii) | AT3G61710.1 (Arabidopsis thaliana) | Atg6 (Drosophila melanogaster) | atg6 (Schizosaccharomyces pombe) | bec-1 (Caenorhabditis elegans) | BECN1 (Bos taurus) | BECN1 (Canis lupus familiaris) | becn1 (Danio rerio) | BECN1 (Gallus gallus) | BECN1 (Homo sapiens) | BECN1 (Macaca mulatta) | Becn1 (Mus musculus) | BECN1 (Pan troglodytes) | Becn1 (Rattus norvegicus) | KLLA0F01166g (Kluyveromyces lactis) | MGG_03694 (Magnaporthe oryzae) | NCU03122 (Neurospora crassa) | Os01g0681400 (Oryza sativa) | Os03g0258500 (Oryza sativa) | Os03g0644000 (Oryza sativa) | VPS30 (Saccharomyces cerevisiae) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
decreased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
increased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) putative (Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
4 |
|
|
|
Ageing Factor Stable ID |
: |
AF_007005 |
Download |
: |
XML |
Protein Information
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005570 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
bec-1 |
177345 |
|
|
Required for normal dauer morphogenesis and lifespan extension. RNA interference results in a shortened lifespan. |
12958363 |
GenAge |
2 |
OB_005574 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
bec-1 |
177345 |
|
|
16% lifespan reduction (compared to wild type) and 25% lifespan reduction (in a daf-2 mutant) for RNAi from beginning of life. For post developmental RNAi maximum lifespan was extended by 10-15% both in wild-type and daf2 mutants. |
19469880 |
GenAge |
3 |
OB_007930 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
bec-1 |
177345 |
|
Other Ageing Factor Name |
Dietary restriction |
|
bec-1 is required for normal dauer morphogenesis and lifespan extension. Knockdown of bec-1 via RNA interference results in a shortened mean and maximum lifespan by 14 and 5% [ 12958363]. bec-1 RNAi does not significantly change the lifespan of wild-type, but completely suppresses the longevity phenotype of eat-2 mutation [17912023; 18282106] and prevents lifespan extension by daf-2(e1370) mutation [ 12958363]. bec-1 RNAi causes the formation of abnormal dauers in a daf-2(e1379) background [ 12958363]. |
17912023, 18282106 |
GenDR |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008238 |
|
2 |
The HomoloGene homology group 2794 contains 2 genes with experimental evidence for ageing relevance (VPS30 - Saccharomyces cerevisiae | bec-1 - Caenorhabditis elegans) and 20 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 2794 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Meléndez A, Tallóczy Z, Seaman M, Eskelinen EL, Hall DH, Levine B:
Autophagy genes are essential for dauer development and life-span extension in C. elegans.
Science. 2003; 301: 1387-91.
PubMed (ID: 12958363), doi:10.1126/science.1087782
MeSH Terms: Autophagy/genetics; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans/genetics; Caenorhabditis elegans/growth & development; Genes, Helminth
- Jia K, Hart AC, Levine B:
Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans.
Autophagy. 2007; 3: 21-5.
PubMed (ID: 17172799)
MeSH Terms: Autophagy/genetics; Autophagy/physiology; Caenorhabditis elegans Proteins/genetics; Heredodegenerative Disorders, Nervous System/prevention & control; Peptides/metabolism
- Jia K, Levine B:
Autophagy is required for dietary restriction-mediated life span extension in C. elegans.
Autophagy. 2007; 3: 597-9.
PubMed (ID: 17912023)
MeSH Terms: Autophagy/physiology; Caenorhabditis elegans/physiology; Caloric Restriction/methods; Food Deprivation/physiology; Longevity/physiology
- Tóth ML, Sigmond T, Borsos E, Barna J, Erdélyi P, Takács-Vellai K, Orosz L, Kovács AL, Csikós G, Sass M, Vellai T:
Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans.
Autophagy. 2008; 4: 330-8.
PubMed (ID: 18219227)
MeSH Terms: Caenorhabditis elegans Proteins/physiology; Caenorhabditis elegans/physiology
- Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C:
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans.
PLoS Genet. 2008; 4: e24.
PubMed (ID: 18282106), PubMed Central (ID: PMC2242811), doi:10.1371/journal.pgen.0040024
MeSH Terms: Autophagy/physiology; Caenorhabditis elegans/growth & development; Caenorhabditis elegans/physiology; Longevity/physiology
- Hashimoto Y, Ookuma S, Nishida E:
Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans.
Genes Cells. 2009; 14: 717-26.
PubMed (ID: 19469880), doi:10.1111/j.1365-2443.2009.01306.x
MeSH Terms: Autophagy/genetics; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans/physiology; Genes, Helminth; Longevity/genetics; Longevity/physiology; RNA Interference
- Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F:
Induction of autophagy by spermidine promotes longevity.
Nat Cell Biol. 2009; 11: 1305-14.
PubMed (ID: 19801973), doi:10.1038/ncb1975
MeSH Terms: Autophagy/drug effects; Longevity/drug effects; Spermidine/pharmacology
Sources
Ageing-related Data Sources
Additional Data Sources