Gene: atg-9 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
atg-9 |
NCBI Gene ID |
: |
178561 |
Species |
: |
Caenorhabditis elegans |
Gene Synonyms |
: |
atg-9 | CELE_T22H9.2 | Protein ATG-9
Source: GPSDB |
Gene Homologs |
: |
AgaP_AGAP001762 (Anopheles gambiae) | atg-9 (Caenorhabditis elegans) | Atg9 (Drosophila melanogaster) | ATG9A (Bos taurus) | ATG9A (Canis lupus familiaris) | atg9a (Danio rerio) | ATG9A (Gallus gallus) | ATG9A (Homo sapiens) | ATG9A (Macaca mulatta) | Atg9a (Mus musculus) | ATG9A (Pan troglodytes) | Atg9a (Rattus norvegicus) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
2 |
|
|
|
Ageing Factor Stable ID |
: |
AF_007022 |
Download |
: |
XML |
Protein Information
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_006449 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
atg-9 |
Caenorhabditis elegans |
178561 |
RNA interference |
- |
wildtype |
yes |
|
|
|
increased |
15.00% |
|
|
|
maximum |
|
|
|
21% (daf-2 mutant) lifespan extension. For postdevelopmental RNAi (wt) maximum lifespan was extended by 10-15% . |
Hashimoto et al. |
2009 |
19469880 |
doi:10.1111/j.1365-2443.2009.01306.x |
GenAge |
2 |
OB_006447 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
atg-9 |
Caenorhabditis elegans |
178561 |
RNA interference |
- |
wildtype |
yes |
|
|
|
decreased |
-35.00% |
|
|
|
Average |
|
|
|
35% mean lifespan reduction |
Tóth et al. |
2008 |
18219227 |
|
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008178 |
|
1 |
The HomoloGene homology group 34495 contains 1 gene with experimental evidence for ageing relevance (atg-9 - Caenorhabditis elegans) and 11 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 34495 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Tóth ML, Sigmond T, Borsos E, Barna J, Erdélyi P, Takács-Vellai K, Orosz L, Kovács AL, Csikós G, Sass M, Vellai T:
Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans.
Autophagy. 2008; 4: 330-8.
PubMed (ID: 18219227)
MeSH Terms: Caenorhabditis elegans Proteins/physiology; Caenorhabditis elegans/physiology
- Hashimoto Y, Ookuma S, Nishida E:
Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans.
Genes Cells. 2009; 14: 717-26.
PubMed (ID: 19469880), doi:10.1111/j.1365-2443.2009.01306.x
MeSH Terms: Autophagy/genetics; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans/physiology; Genes, Helminth; Longevity/genetics; Longevity/physiology; RNA Interference
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources