1 |
OB_005420 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ifta-2 |
Caenorhabditis elegans |
189055 |
Knockout |
- |
wildtype |
yes |
|
|
|
increased |
50.00% |
|
|
|
unknown |
|
|
|
Knockouts have an extended lifespan phenotype (40-50%) and are defective in dauer formation due to defects in daf-2 receptor signalling pathway in ciliatedsensory neurons. There was no additive effect of the ifta-2 mutation on the daf-2 longevity phenotype. |
Schafer et al. |
2006 |
16968739 |
doi:10.1242/jcs.03187 |
GenAge |
2 |
OB_002276 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
ifta-2 |
Caenorhabditis elegans |
189055 |
loss of function |
tm1724 |
unknown |
unknown |
|
|
|
increased |
47.57% |
24.6 |
16.67 |
days |
mean |
20 |
℃ |
hermaphrodite |
Double mutation extends lifespan approximately 48%. The ifta-2(tm1724);daf-2(e1370) double mutants have a lifespan similar to that of daf-2(e1370) alone or ifta-2(tm1724) alone, indicating that there is no additive effect of the ifta-2 mutation on the daf-2 longevity phenotype. |
Schafer et al. |
2006 |
16968739 |
doi:10.1242/jcs.03187 |
Lifespan Observations Database (ID: 3552) |
3 |
OB_002268 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ifta-2 |
Caenorhabditis elegans |
189055 |
loss of function |
tm1724 |
unknown |
unknown |
|
|
|
increased |
44.04% |
26.33 |
18.28 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutants have an extended lifespan phenotype (44%). Other phenotypes: Defective in dauer formation due to defects in daf-2 receptor signalling pathway in ciliatedsensory neurons. |
Schafer et al. |
2006 |
16968739 |
doi:10.1242/jcs.03187 |
Lifespan Observations Database (ID: 3545) |
4 |
OB_002274 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ifta-2 |
Caenorhabditis elegans |
189055 |
loss of function |
tm1724 |
unknown |
unknown |
|
|
|
increased |
39.53% |
23.26 |
16.67 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutation extends lifespan approximately 40%. |
Schafer et al. |
2006 |
16968739 |
doi:10.1242/jcs.03187 |
Lifespan Observations Database (ID: 3550) |
5 |
OB_002277 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ifta-2 |
Caenorhabditis elegans |
189055 |
loss of function |
tm1724 |
unknown |
unknown |
|
|
|
increased |
21.05% |
23 |
19 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutation extends lifespan approximately 21%. |
Schafer et al. |
2006 |
16968739 |
doi:10.1242/jcs.03187 |
Lifespan Observations Database (ID: 3553) |
6 |
OB_002270 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ifta-2 |
Caenorhabditis elegans |
189055 |
loss of function |
tm1724 |
unknown |
unknown |
|
|
|
increased |
14.63% |
19.67 |
17.16 |
days |
mean |
20 |
℃ |
hermaphrodite |
Mutants have extended lifespan (16%). |
Schafer et al. |
2006 |
16968739 |
doi:10.1242/jcs.03187 |
Lifespan Observations Database (ID: 3547) |
7 |
OB_002279 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
loss of function |
mu86 |
unknown |
unknown |
ifta-2 |
Caenorhabditis elegans |
189055 |
loss of function |
tm1724 |
unknown |
unknown |
|
|
|
increased |
5.00% |
19.95 |
19 |
days |
mean |
20 |
℃ |
hermaphrodite |
Double mutation extends lifespan about 5%. |
Schafer et al. |
2006 |
16968739 |
doi:10.1242/jcs.03187 |
Lifespan Observations Database (ID: 3555) |
8 |
OB_002272 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ifta-2 |
Caenorhabditis elegans |
189055 |
over-expression |
- |
unknown |
unknown |
ifta-2 |
Caenorhabditis elegans |
189055 |
loss of function |
tm1724 |
unknown |
unknown |
|
|
|
none |
3.15% |
17.7 |
17.16 |
days |
mean |
20 |
℃ |
hermaphrodite |
Rescue of IFTA-2::GFP in ifta-2(tm1724) mutants results in greatly reduced lifespan compared with the original ifta-2(tm1724) mutant and is not different from wild type. |
Schafer et al. |
2006 |
16968739 |
doi:10.1242/jcs.03187 |
Lifespan Observations Database (ID: 3549) |
9 |
OB_002271 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ifta-2 |
Caenorhabditis elegans |
189055 |
over-expression |
- |
unknown |
unknown |
|
|
|
none |
-4.55% |
16.38 |
17.16 |
days |
mean |
20 |
℃ |
hermaphrodite |
IFTA-2::GFP in wild type lifespan is not significantly different than wild type, indicating that the transgene has no effect on lifespan. |
Schafer et al. |
2006 |
16968739 |
doi:10.1242/jcs.03187 |
Lifespan Observations Database (ID: 3548) |