Gene: mcm-2 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
mcm-2 |
NCBI Gene ID |
: |
174841 |
Species |
: |
Caenorhabditis elegans |
Gene Synonyms |
: |
CELE_Y17G7B.5 | mcm-2 | Protein MCM-2
Source: GPSDB |
Gene Homologs |
: |
AgaP_AGAP004275 (Anopheles gambiae) | AGOS_AFR178W (Eremothecium gossypii) | AT1G44900.1 (Arabidopsis thaliana) | KLLA0F12584g (Kluyveromyces lactis) | mcm-2 (Caenorhabditis elegans) | MCM2 (Bos taurus) | MCM2 (Canis lupus familiaris) | mcm2 (Danio rerio) | Mcm2 (Drosophila melanogaster) | MCM2 (Gallus gallus) | MCM2 (Homo sapiens) | MCM2 (Macaca mulatta) | Mcm2 (Mus musculus) | MCM2 (Pan troglodytes) | Mcm2 (Rattus norvegicus) | MCM2 (Saccharomyces cerevisiae) | mcm2 (Schizosaccharomyces pombe) | MGG_08122 (Magnaporthe oryzae) | NCU04327 (Neurospora crassa) | Os11g0484300 (Oryza sativa) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
decreased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
increased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) putative (Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
4 |
|
|
|
Ageing Factor Stable ID |
: |
AF_007120 |
Download |
: |
XML |
Protein Information
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005539 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
mcm-2 |
174841 |
|
|
RNAi let to a 33% decrease in median lifespan in daf-2 background and a 14% decrease in lifespan in a wild-type background. |
18006689 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_001829 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
mcm-2 |
Caenorhabditis elegans |
174841 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
72.11% |
25.3 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3146) |
2 |
OB_005538 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mcm-2 |
Caenorhabditis elegans |
174841 |
RNA interference |
- |
wildtype |
yes |
|
|
|
increased |
15.00% |
|
|
|
Average |
|
|
|
RNA interference in adulthood resulted in a 15% mean lifespan extension. |
Curran et al. |
2007 |
17411345 |
doi:10.1371/journal.pgen.0030056 |
GenAge |
3 |
OB_005540 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mcm-2 |
Caenorhabditis elegans |
174841 |
RNA interference |
- |
wildtype |
yes |
|
|
|
decreased |
-14.00% |
|
|
|
Median |
|
|
|
RNAi let to a 33% decrease in median lifespan in daf-2 background and a 14% decrease in lifespan in a wild-type background. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
GenAge |
4 |
OB_001763 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mcm-2 |
Caenorhabditis elegans |
174841 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-14.29% |
12.6 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3087) |
5 |
OB_002009 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
deletion / null |
mgDf47 |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
loss of function |
e1370 |
unknown |
unknown |
mcm-2 |
Caenorhabditis elegans |
174841 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-31.29% |
10.1 |
14.7 |
days |
median |
25 |
℃ |
hermaphrodite |
A genome-wide RNAi screen was performed to identify genes necessary for the extended life span of daf-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span. Some of these gene inactivations dramatically shorten daf-2 mutant life span but less dramatically shorten daf-2; daf-16 mutant or wild-type life span. RNAi experiments were initiated at egg. Animals were grown at 15 degrees C until L4, then transferred to 25 degrees C. |
Samuelson et al. |
2007 |
18006689 |
doi:10.1101/gad.1588907 |
Lifespan Observations Database (ID: 3308) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008173 |
|
2 |
The HomoloGene homology group 3325 contains 2 genes with experimental evidence for ageing relevance (Mcm2 - Mus musculus | mcm-2 - Caenorhabditis elegans) and 18 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 3325 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Curran SP, Ruvkun G:
Lifespan regulation by evolutionarily conserved genes essential for viability.
PLoS Genet. 2007; 3: e56.
PubMed (ID: 17411345), PubMed Central (ID: PMC1847696), doi:10.1371/journal.pgen.0030056
MeSH Terms: Caenorhabditis elegans/genetics; Caenorhabditis elegans/physiology; Conserved Sequence/genetics; Evolution, Molecular; Genes, Essential; Genes, Helminth; Longevity/genetics
- Samuelson AV, Carr CE, Ruvkun G:
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.
Genes Dev. 2007; 21: 2976-94.
PubMed (ID: 18006689), PubMed Central (ID: PMC2049198), doi:10.1101/gad.1588907
MeSH Terms: Caenorhabditis elegans/physiology; Genes, Helminth; Insulin-Like Growth Factor I/genetics; Mutation; Signal Transduction/physiology
Sources
Ageing-related Data Sources
Additional Data Sources