Gene: ser-4 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | ser-4 | ||||||||||||||||||||||||
NCBI Gene ID | : | 175322 | ||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||
Gene Synonyms | : | CELE_Y22D7AR.13 | Protein SER-4 | ser-4 Source: GPSDB |
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Gene Homologs | : | 5-HT1A (Drosophila melanogaster) | GPR5HT1A (Anopheles gambiae) | htr1ab (Danio rerio) | ser-4 (Caenorhabditis elegans) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_007130 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Protein SER-4 | Caenorhabditis elegans | G5EGH0 (UniProtKB/TrEMBL) | G5EGH0_CAEEL (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_002455 | Caenorhabditis elegans | N2 |
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decreased | -11.30% | 10.2 | 11.5 | days | mean | 25 | ℃ | hermaphrodite | Deletion shortened early- to mid-lifespan about 10% | Murakami et al. | 2007 | 17559503 | doi:10.1111/j.1474-9726.2007.00303.x | Lifespan Observations Database (ID: 3716) | ||||||||||||||||
2 | OB_005891 | Caenorhabditis elegans |
|
decreased | unknown | Deletion shortened early- to mid-lifespan. | Murakami et al. | 2007 | 17559503 | doi:10.1111/j.1474-9726.2007.00303.x | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_008203 |
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1 | The HomoloGene homology group 124371 contains 1 gene with experimental evidence for ageing relevance (ser-4 - Caenorhabditis elegans) and 3 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 124371 |
Sequences
G5EGH0_CAEEL | G5EGH0 | Protein SER-4 (Caenorhabditis elegans) from UniProtKB/TrEMBL Length: 445 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 G5EGH0_CAEEL 1 MIDETLLNLTASPSSQPATLLSAVARGTHLVDQFPAHAEIFSDIERPLVQTVILASVLLVLILSCFIGNLFVILAIIMERDLRGRPQYYLIFSLAVADLLVGMIVTPLGAWFTVTGTWNLGVVVCDFWISVDVLVCTASILHLVAIALDRYWSITDICYVQNRTPKRITLMLAVIWFTSLLISLAPFAGWKDEGFSDRVLKSHVCLISQQISYQVFSTATAFYIPLIAIICVYWKIMRAAKKRFKRERDRRTVIRPPPDAIDEKKAMMPKKSKKCPLPPAVVISDIQANGGTGGKTNSIKNPPRHNESSSSASEEERTMTQTNHAPGDVTTQETKIDEENGRSKPGIVKRRRRTKESNEMKRERKAWRTLAIITGTFVACWTPFFLVSIYRPICGCQISPVLEQVTLWLGYLNSALNPIIYTVFSQDFRAAFKRIIKRMCLIHDY 445
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Murakami H, Murakami S:
Serotonin receptors antagonistically modulate Caenorhabditis elegans longevity.
Aging Cell. 2007; 6: 483-8.
PubMed (ID: 17559503), doi:10.1111/j.1474-9726.2007.00303.x
MeSH Terms: Caenorhabditis elegans/genetics; Caenorhabditis elegans/physiology; Longevity/genetics; Longevity/physiology; Receptors, G-Protein-Coupled/genetics; Receptors, Serotonin/metabolism; Serotonin/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/TrEMBL