Gene: aakb-2 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | aakb-2 | ||||||||||||||||
NCBI Gene ID | : | 176552 | ||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||
Gene Synonyms | : | aakb-2 | CELE_Y47D3A.15 | Protein AAKB-2 Source: GPSDB |
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Gene Homologs | : | aakb-1 (Caenorhabditis elegans) | aakb-2 (Caenorhabditis elegans) | amk2 (Schizosaccharomyces pombe) | KINB1 (Arabidopsis thaliana) | LOC100856379 (Canis lupus familiaris) | MGG_06930 (Magnaporthe oryzae) | NCU03837 (Neurospora crassa) | Os05g0491200 (Oryza sativa) | PRKAB2 (Bos taurus) | prkab2 (Danio rerio) | PRKAB2 (Gallus gallus) | PRKAB2 (Homo sapiens) | PRKAB2 (Macaca mulatta) | Prkab2 (Mus musculus) | PRKAB2 (Pan troglodytes) | Prkab2 (Rattus norvegicus) | SIP2 (Saccharomyces cerevisiae) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_007183 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Protein AAKB-2 | Caenorhabditis elegans | Q9NAH7 (UniProtKB/TrEMBL) | Q9NAH7_CAEEL (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_006223 | Caenorhabditis elegans |
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RNA interference resulted in decreased lifespan and earlier accumulation of lipofuscin. | 16673436 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_006224 | Caenorhabditis elegans |
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decreased | unknown | RNA interference resulted in decreased lifespan and earlier accumulation of lipofuscin. | Ha et al. | 2006 | 16673436 | doi:10.1002/pmic.200500395 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008372 | 3 | The HomoloGene homology group 38046 contains 3 genes with experimental evidence for ageing relevance (SIP2 - Saccharomyces cerevisiae | aakb-1 - Caenorhabditis elegans | aakb-2 - Caenorhabditis elegans) and 14 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 38046 |
Sequences
Q9NAH7_CAEEL | Q9NAH7 | Protein AAKB-2 (Caenorhabditis elegans) from UniProtKB/TrEMBL Length: 274 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 Q9NAH7_CAEEL 1 MGNNQSGGPDARYGGPNDKAGLRRHRMMSETAKIAGQVLPNPDGGPPMIFDDGNEDKSGECPVVFRWSFTQNAQPRVVHIVGSWDNWQTRIPMVKSTNDFSTIIDLQPGQYEYKFQVDGSWVVDDNQGKAQDVHGNENNMINIQDSDFAVFEALDEDFQSSTAGEVLRGESESTKNHDTPNDRELEKLRSFTQEIPSMDMLRKAAGPPVIPPQLMQVLLNKETPESCDPNVLPEPNHVMLNHMYALSIKDSVMVLSSTQRYRKKFVTTLLYKPV 274
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Ha MK, Soo Cho J, Baik OR, Lee KH, Koo HS, Chung KY:
Caenorhabditis elegans as a screening tool for the endothelial cell-derived putative aging-related proteins detected by proteomic analysis.
Proteomics. 2006; 6: 3339-51.
PubMed (ID: 16673436), doi:10.1002/pmic.200500395
MeSH Terms: Caenorhabditis elegans Proteins/physiology; Caenorhabditis elegans/physiology; Cell Aging/physiology; Endothelial Cells/physiology
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/TrEMBL