Gene: cku-70 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | cku-70 | ||||||||||||||||||||||||
NCBI Gene ID | : | 176546 | ||||||||||||||||||||||||
Species | : | Caenorhabditis elegans | ||||||||||||||||||||||||
Gene Synonyms | : | CELE_Y47D3A.4 | cku-70 | Protein CKU-70 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP002690 (Anopheles gambiae) | cku-70 (Caenorhabditis elegans) | Irbp (Drosophila melanogaster) | KLLA0C06226g (Kluyveromyces lactis) | KU70 (Arabidopsis thaliana) | LOC100536337 (Danio rerio) | MGG_01512 (Magnaporthe oryzae) | NCU08290 (Neurospora crassa) | Os07g0184900 (Oryza sativa) | pku70 (Schizosaccharomyces pombe) | XRCC6 (Bos taurus) | XRCC6 (Canis lupus familiaris) | xrcc6 (Danio rerio) | XRCC6 (Gallus gallus) | XRCC6 (Homo sapiens) | XRCC6 (Macaca mulatta) | Xrcc6 (Mus musculus) | XRCC6 (Pan troglodytes) | Xrcc6 (Rattus norvegicus) | YKU70 (Saccharomyces cerevisiae) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_007186 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_006877 | Caenorhabditis elegans |
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RNA interference of cku-70 further increases the lifespan of daf-2 mutants. Lifespan of daf-16 mutants was slightly decreased. | 16099946 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_002898 | Caenorhabditis elegans |
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increased | 35.00% | RNA interference of cku-70 further increases the lifespan of daf-2 mutants by 35%. | McColl et al. | 2005 | 16099946 | doi:10.1096/fj.04-2447fje | Lifespan Observations Database (ID: 420) | ||||||||||||||||||||||||
2 | OB_002899 | Caenorhabditis elegans |
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increased | 11.00% | RNA interference of cku-70 further decreases the lifespan of daf-16 mutants by 11%. | McColl et al. | 2005 | 16099946 | doi:10.1096/fj.04-2447fje | Lifespan Observations Database (ID: 421) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
Sequences
no sequence information available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- McColl G, Vantipalli MC, Lithgow GJ:
The C. elegans ortholog of mammalian Ku70, interacts with insulin-like signaling to modulate stress resistance and life span.
FASEB J. 2005; 19: 1716-8.
PubMed (ID: 16099946), PubMed Central (ID: PMC1400606), doi:10.1096/fj.04-2447fje
MeSH Terms: Antigens, Nuclear/physiology; Caenorhabditis elegans Proteins/chemistry; Caenorhabditis elegans Proteins/genetics; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology; Insulin/metabolism; Longevity
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed