Gene: dve-1 - Caenorhabditis elegans
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
dve-1 |
NCBI Gene ID |
: |
180398 |
Species |
: |
Caenorhabditis elegans |
Gene Synonyms |
: |
CELE_ZK1193.5 | dve-1 | Protein DVE-1
Source: GPSDB |
Gene Homologs |
: |
AgaP_AGAP006642 (Anopheles gambiae) | dve (Drosophila melanogaster) | dve-1 (Caenorhabditis elegans) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
2 |
|
|
|
Ageing Factor Stable ID |
: |
AF_007308 |
Download |
: |
XML |
Protein Information
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_007955 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
dve-1 |
180398 |
|
Other Ageing Factor Name |
Dietary restriction |
|
dve-1 RNAi attenuates lifespan extension by bDR, but only partially that of daf-2 mutation. dve-1 RNAi attenuates protection against oxidative stress by bDR. dve-1 expression is not induced by bDR [ 19924292]. |
19924292 |
GenDR |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_006475 |
Caenorhabditis elegans |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
dve-1 |
Caenorhabditis elegans |
180398 |
RNA interference |
- |
wildtype |
yes |
|
|
|
decreased |
|
|
|
|
unknown |
|
|
|
Shortned lifespan compared to wild type controls. |
Durieux et al. |
2011 |
21215371 |
doi:10.1016/j.cell.2010.12.016 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008241 |
|
1 |
The HomoloGene homology group 35113 contains 1 gene with experimental evidence for ageing relevance (dve-1 - Caenorhabditis elegans) and 2 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 35113 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Zhang M, Poplawski M, Yen K, Cheng H, Bloss E, Zhu X, Patel H, Mobbs CV:
Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling.
PLoS Biol. 2009; 7: e1000245.
PubMed (ID: 19924292), PubMed Central (ID: PMC2774267), doi:10.1371/journal.pbio.1000245
MeSH Terms: Aging/metabolism; CREB-Binding Protein/metabolism; Caenorhabditis elegans/physiology; Insulin/metabolism; Longevity/physiology; Matrix Attachment Region Binding Proteins/metabolism; Signal Transduction/genetics; Signal Transduction/physiology
- Durieux J, Wolff S, Dillin A:
The cell-non-autonomous nature of electron transport chain-mediated longevity.
Cell. 2011; 144: 79-91.
PubMed (ID: 21215371), PubMed Central (ID: PMC3062502), doi:10.1016/j.cell.2010.12.016
MeSH Terms: Caenorhabditis elegans/physiology; Cell Aging; Electron Transport; Longevity
Sources
Ageing-related Data Sources
Additional Data Sources