Gene: kermit - Drosophila melanogaster
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | kermit | ||||||||||||||||
NCBI Gene ID | : | 46027 | ||||||||||||||||
Species | : | Drosophila melanogaster | ||||||||||||||||
Gene Synonyms | : | CG11546 | CG11546 gene product from transcript CG11546-RB | CG11546-PA | CG11546-PB | CG11546-PC | CG11546-PD | dGIPC | dKermit | Dmel_CG11546 | DmelCG11546 | Kermit | kermit | kermit-PA | kermit-PB | kermit-PC | kermit-PD | l(2)02045 | lethal (2) 02045 Source: GPSDB |
||||||||||||||||
Gene Homologs | : | AgaP_AGAP007674 (Anopheles gambiae) | GIPC3 (Bos taurus) | GIPC3 (Canis lupus familiaris) | GIPC3 (Homo sapiens) | GIPC3 (Macaca mulatta) | Gipc3 (Mus musculus) | GIPC3 (Pan troglodytes) | Gipc3 (Rattus norvegicus) | kermit (Drosophila melanogaster) | LOC100857667 (Gallus gallus) | zgc:136839 (Danio rerio) | ||||||||||||||||
Ageing Relevance Analysis | : |
|
||||||||||||||||
Ageing Factor Stable ID | : | AF_007422 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
GH21964p | Drosophila melanogaster | Q7JX82 (UniProtKB/TrEMBL) | Q7JX82_DROME (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_006384 | Drosophila melanogaster |
|
Disruption of dGIPC (kermit) function results in premature loss of locomotor activity and reduced mean life span. | 21029723 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_006385 | Drosophila melanogaster |
|
decreased | -30.00% | Average | Disruption of dGIPC (kermit) function results in premature loss of locomotor activity and reduced mean life span. | Kim et al. | 2010 | 21029723 | doi:10.1016/j.bbrc.2010.10.095 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008162 | 1 | The HomoloGene homology group 77068 contains 1 gene with experimental evidence for ageing relevance (kermit - Drosophila melanogaster) and 10 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 77068 |
Sequences
Q7JX82_DROME | Q7JX82 | GH21964p (Drosophila melanogaster) from UniProtKB/TrEMBL Length: 336 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 Q7JX82_DROME 1 MPLFTRKSPKQGPTSDGGSQFGSRSSMNSGSSQGSHISNNNNNSIPEKTKPPLVFHCQLAHGSPTGLIHDFSSVRELYQKIAECFDISEKDILFCTLNSHKVDMTRLLGGQIGLDDFIFAHRKGRPKEIEIVKSQDALGLTITDNGAGYAFIKRIKEDSIIDRIEHISVGDHIEKLNGQNMVGKRHYEVARMLKDIATGETFTLRLVEPVRSGFQGIGPRSQSRASGSAGGKNYGSGKETLRFKANGNAQIEPQFDEATVAGIEAINNLLESFMGINDTELASQIWDLGDQKSNSMDFAEAIDNSDLESFGFTDDFIIELWGAITDARRKSTTSPK 336
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Kim J, Lee S, Ko S, Kim-Ha J:
dGIPC is required for the locomotive activity and longevity in Drosophila.
Biochem Biophys Res Commun. 2010; 402: 565-70.
PubMed (ID: 21029723), doi:10.1016/j.bbrc.2010.10.095
MeSH Terms: Brain/metabolism; Carrier Proteins/metabolism; Drosophila Proteins/metabolism; Drosophila melanogaster/physiology; Locomotion; Longevity; Neuroglia/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/TrEMBL