Gene: LBR - Drosophila melanogaster
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | LBR | ||||||||||||||||
NCBI Gene ID | : | 37482 | ||||||||||||||||
Species | : | Drosophila melanogaster | ||||||||||||||||
Gene Synonyms | : | CG17952 | CG17952-PA | CG17952-PB | CG17952-PC | dLBR | Dmel_CG17952 | DmelCG17952 | Lamin B receptor | lamin B receptor | LBR | LBR-PA | LBR-PB | LBR-PC Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP003745 (Anopheles gambiae) | AGOS_AFR346W (Eremothecium gossypii) | ERG24 (Saccharomyces cerevisiae) | erg24 (Schizosaccharomyces pombe) | KLLA0C12265g (Kluyveromyces lactis) | LBR (Bos taurus) | LBR (Canis lupus familiaris) | lbr (Danio rerio) | LBR (Drosophila melanogaster) | LBR (Gallus gallus) | LBR (Homo sapiens) | LBR (Macaca mulatta) | Lbr (Mus musculus) | LBR (Pan troglodytes) | Lbr (Rattus norvegicus) | MGG_13986 (Magnaporthe oryzae) | NCU08762 (Neurospora crassa) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_007535 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Lamin-B receptor | Drosophila melanogaster | Q8MLV1 (UniProtKB/Swiss-Prot) | LBR_DROME (UniProtKB/Swiss-Prot) | Anchors the lamina and the heterochromatin to the inner nuclear membrane. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_006390 | Drosophila melanogaster |
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decreased | unknown | Overexpression of lamin B receptor in the adult muscle and in the abdominal fat body, resulted in a 54% and respectively 46% reduction of mean life span. | Brandt et al. | 2008 | 18494863 | doi:10.1111/j.1474-9726.2008.00406.x | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008578 | 2 | The HomoloGene homology group 2455 contains 2 genes with experimental evidence for ageing relevance (ERG24 - Saccharomyces cerevisiae | LBR - Drosophila melanogaster) and 15 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 2455 |
Sequences
LBR_DROME | Q8MLV1 | Lamin-B receptor (Drosophila melanogaster) from UniProtKB/Swiss-Prot Length: 741 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 LBR_DROME 1 MQHSPSTTTDHIHFAARFFDRNSYTMDRRLRRPRRTEDVSSGPLLAQSKQPSLLPVTRRTGSVTAAGATATATATAGPATRTRASPSRNKVVAPPSPDLGPRTRRSSRPRSSVGPLTGSGSGSSLPIKAAIKARTPIPEVSEVSSPIRLSTSNLPMTLTTNTSSGAPNKAFNTSSVNSGNSFSRTTTSSTTTTTERIEIRAEGDGEVDTDSIRKRITERLRRSVSKTISNLAGTPVTNTEEGSRYSRSVSRSVYDDEKSSKRSYSTGEEDIDEEDELEEDQFRSFNVTRKSATPAEISCRQLKAPREFGGWLGAFLFLLLLPTAVYYLTWSCTARNACQFKHLNLGILLDVNYLTRQVFQPRVVGAFAAYQVVVFLLVALLPGRRVHLTRETYKFNCLAVSLTLLIASGVAEYLKYPVVTFVLRHYLRFCIFGLVGAFVAAAWSYWLVDTAKYNVLRQTLTNDYGRTGSFVVDFALGRQLNPKWLGRVDWKQFQYRLSLVTTLIYATCYIYQTLVWPQKPQLGEQEGYLYQAKYYWNNVNYDPATLFSASCLLFYVLDAIIFEHHLSSSFELQHEGYGCLLLLRYAATPYLLTAVTKYFYEQRVPISCWYAPLAVAALLSLGLLVKRFSCAYKYKYRLNSQSPIFANIETIHTYQGSRLLLSGMWGWVRQPNYLGDIVALLALAAPMALRPAWPPVLGLSLIILLLLHRATRANARNQARYHSSWQRYSTQVRSYILPRVY 741
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Brandt A, Krohne G, Grosshans J:
The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies.
Aging Cell. 2008; 7: 541-51.
PubMed (ID: 18494863), doi:10.1111/j.1474-9726.2008.00406.x
MeSH Terms: Aging/physiology; Drosophila Proteins/metabolism; Drosophila melanogaster/physiology; Lamin Type B/metabolism; Nuclear Proteins/metabolism; Protein Prenylation
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot