Gene: Pex16 - Drosophila melanogaster
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
Pex16 |
NCBI Gene ID |
: |
40293 |
Species |
: |
Drosophila melanogaster |
Gene Synonyms |
: |
CG3947 | CG3947-PA | Dmel_CG3947 | DmelCG3947 | DmelPex16 | Peroxin 16 | peroxin 16 | Pex16 | pex16 | Pex16-PA
Source: GPSDB |
Gene Homologs |
: |
AgaP_AGAP002283 (Anopheles gambiae) | MGG_09011 (Magnaporthe oryzae) | NCU01850 (Neurospora crassa) | PEX16 (Bos taurus) | PEX16 (Canis lupus familiaris) | pex16 (Danio rerio) | Pex16 (Drosophila melanogaster) | PEX16 (Gallus gallus) | PEX16 (Homo sapiens) | PEX16 (Macaca mulatta) | Pex16 (Mus musculus) | PEX16 (Pan troglodytes) | Pex16 (Rattus norvegicus) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
2 |
|
|
|
Ageing Factor Stable ID |
: |
AF_007639 |
Download |
: |
XML |
Protein Information
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_009922 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
Pex16 |
40293 |
|
|
Mutant flies lack normal peroxisomes, have an reduced adult body size (70%-85% smaller than controls) and rozy eyes, show locomotion defects and defects in the development of the nervous system. The mean longevity of the females was reduced to one-third (data not shown) and that of the males to one-fourth of the wild-type lifespan. The shortened lifespan was rescued by the simultaneous overexpression of pex16 in the fat body and differentiated neurons. |
21826223 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_009923 |
Drosophila melanogaster |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Pex16 |
Drosophila melanogaster |
40293 |
Mutations |
- |
wildtype |
yes |
|
|
|
decreased |
-75.00% |
|
|
|
unknown |
|
|
male |
Mutant flies lack normal peroxisomes, have an reduced adult body size (70%-85% smaller than controls) and rozy eyes, show locomotion defects and defects in the development of the nervous system. The mean longevity of the females was reduced to one-third (data not shown) and that of the males to one-fourth of the wild-type lifespan. The shortened lifespan was rescued by the simultaneous overexpression of pex16 in the fat body and differentiated neurons. |
Nakayama et al. |
2011 |
21826223 |
doi:10.1371/journal.pone.0022984 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008245 |
|
1 |
The HomoloGene homology group 3537 contains 1 gene with experimental evidence for ageing relevance (pex16 - Drosophila melanogaster) and 12 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 3537 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Nakayama M, Sato H, Okuda T, Fujisawa N, Kono N, Arai H, Suzuki E, Umeda M, Ishikawa HO, Matsuno K:
Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes.
PLoS ONE. 2011; 6: e22984.
PubMed (ID: 21826223), PubMed Central (ID: PMC3149631), doi:10.1371/journal.pone.0022984
MeSH Terms: Membrane Proteins/genetics; Peroxisomes/metabolism; Zellweger Syndrome/genetics; Zellweger Syndrome/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources