Gene: Gclm - Drosophila melanogaster
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | Gclm | ||||||||||||||||||||||||
NCBI Gene ID | : | 248194 | ||||||||||||||||||||||||
Species | : | Drosophila melanogaster | ||||||||||||||||||||||||
Gene Synonyms | : | box | CG4919 | CG4919-PA | CG4919-PB | Dmel_CG4919 | DmelCG4919 | DmGCLM | DmGCSl | gamma-Glutamylcysteine synthetase regulatory subunit | GCLm | Gclm | Gclm-PA | Gclm-PB | GCSl | Gcsl | Glutamate-cysteine ligase modifier subunit Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP012038 (Anopheles gambiae) | E01A2.1 (Caenorhabditis elegans) | GCLM (Bos taurus) | GCLM (Canis lupus familiaris) | gclm (Danio rerio) | Gclm (Drosophila melanogaster) | GCLM (Gallus gallus) | GCLM (Homo sapiens) | Gclm (Mus musculus) | GCLM (Pan troglodytes) | Gclm (Rattus norvegicus) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_007673 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
GH03051p | Drosophila melanogaster | Q9VCW6 (UniProtKB/TrEMBL) | Q9VCW6_DROME (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_003642 | Drosophila melanogaster |
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increased | 24.00% | Overexpression extended the mean lifespan by up to 24%. | Orr et al. | 2005 | 16148000 | doi:10.1074/jbc.M508272200 | Lifespan Observations Database (ID: 511) | ||||||||||||||||||||||||
2 | OB_007809 | Drosophila melanogaster |
|
increased | 24.00% | Average | Overexpression extended the mean lifespan by up to 24%. | Orr et al. | 2005 | 16148000 | doi:10.1074/jbc.M508272200 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008210 | 2 | The HomoloGene homology group 1557 contains 2 genes with experimental evidence for ageing relevance (GCLM - Homo sapiens | Gclm - Drosophila melanogaster) and 9 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 1557 |
Sequences
Q9VCW6_DROME | Q9VCW6 | GH03051p (Drosophila melanogaster) from UniProtKB/TrEMBL Length: 285 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 Q9VCW6_DROME 1 MIPTITKKYQNVVISTGNIIATELGQRKSNEELYDGLKITLHTDSTAERVVVEKEIDELHGRVQRATQELTTRLTENGRNEISIGAKIFLNRHSTESVNQAVEELLHILSVTHVDNVVLAYHPNAVATATPVATTKPPCSEDSNVSRATNWSQRNGKEGVAELKELYKTLEQYALKQQITQLGIADLDAAALEELHNSAQVVPTIAQVNLSTCCVVPPELQEFCTAHDIQLNTHSDPELLLPVEQFDGLVPGYTIDWTLRYQVHVRCRGVLTAKGYIVGASRSSV 285
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Orr WC, Radyuk SN, Prabhudesai L, Toroser D, Benes JJ, Luchak JM, Mockett RJ, Rebrin I, Hubbard JG, Sohal RS:
Overexpression of glutamate-cysteine ligase extends life span in Drosophila melanogaster.
J Biol Chem. 2005; 280: 37331-8.
PubMed (ID: 16148000), doi:10.1074/jbc.M508272200
MeSH Terms: Drosophila melanogaster/enzymology; Drosophila melanogaster/physiology; Glutamate-Cysteine Ligase/genetics; Glutamate-Cysteine Ligase/metabolism; Longevity/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- UniProtKB/TrEMBL
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed