Gene: chico - Drosophila melanogaster
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
chico |
NCBI Gene ID |
: |
64880 |
Species |
: |
Drosophila melanogaster |
Gene Synonyms |
: |
CG5686 | CG5686 gene product from transcript CG5686-RB | CG5686-PA | CG5686-PB | CG5686-PC | chic | CHICO | Chico | chico | chico-PA | chico-PB | chico-PC | dIRS | Dmel_CG5686 | DmelCG5686 | flipper | fs(2)4 | fs(2)ry4 | Insulin receptor substrate | insulin receptor substrate | insulin-like receptor substrate | IRS | IRS/chico
Source: GPSDB |
Gene Homologs |
: |
|
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
increased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Total |
2 |
|
|
|
Ageing Factor Stable ID |
: |
AF_007697 |
Download |
: |
XML |
Protein Information
Protein Name |
Species |
UniProt Accession Number |
UniProt Entry Name |
Protein Function |
Sequence |
Insulin receptor substrate 1 |
Drosophila melanogaster |
Q9XTN2 (UniProtKB/Swiss-Prot) |
IRS1_DROME (UniProtKB/Swiss-Prot) |
Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation. |
View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_006795 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
chico |
64880 |
|
|
Lifespan extension of 48% in homozygotes and 36% in heterozygotes. |
11292874 |
GenAge |
2 |
OB_007942 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
chico |
64880 |
|
Other Ageing Factor Name |
Dietary restriction |
|
Mutation in chico extends mean, median, and maximum lifespan by 56%, 48%, and 42% in homozygotes and 44%, 36%, and 35% in heterozygotes. chico mutation produces dwarf, long-lived females at normal nutrition. Male heterozygous live 13% longer than wild-type, but male homozygous have a shortened lifespan [ 11292874]. Wild-type and chico mutant females have similar peak lifespan under DR, but the food concentration at which these are achieved is shifted to higher amounts. chico mutation induces a state equivalent to submaximal, DR-induced slowing of aging [ 11951037]. chico heterzoygous females have a reduced fecundity and homozygous recessive mutants are sterile. chico heterozygous mutants are resistant to starvation but not oxidative stress or temperature stress [ 11292874]. |
11292874, 11951037 |
GenDR |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Homology Analysis
no homology analysis observation available
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, Leevers SJ, Partridge L:
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.
Science. 2001; 292: 104-6.
PubMed (ID: 11292874), doi:10.1126/science.1057991
MeSH Terms: Aging/physiology; Drosophila Proteins; Drosophila melanogaster/physiology; Insect Proteins/genetics; Insect Proteins/metabolism; Intracellular Signaling Peptides and Proteins; Longevity/physiology; Receptor Protein-Tyrosine Kinases; Receptor, Insulin/metabolism
- Clancy DJ, Gems D, Hafen E, Leevers SJ, Partridge L:
Dietary restriction in long-lived dwarf flies.
Science. 2002; 296: 319.
PubMed (ID: 11951037), doi:10.1126/science.1069366
MeSH Terms: Carrier Proteins; Drosophila Proteins/physiology; Drosophila melanogaster/physiology; Energy Intake; Intracellular Signaling Peptides and Proteins; Longevity/physiology
- Tu MP, Epstein D, Tatar M:
The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico.
Aging Cell. 2002; 1: 75-80.
PubMed (ID: 12882356)
MeSH Terms: Aging/genetics; Carrier Proteins/genetics; Drosophila Proteins/genetics; Drosophila melanogaster/genetics; Intracellular Signaling Peptides and Proteins; Longevity/genetics; Mutation/genetics; Receptor, Insulin/genetics
Sources
Ageing-related Data Sources
Additional Data Sources