Release 1 - Aug 15, 2014

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Gene: Top1 - Drosophila melanogaster

Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Ageing relevance by computational analysis: putative
Defined by: NCBI Gene ID
Ageing relevance by computational analysis: putative
Defined by: NCBI Gene ID

Summary

Gene Symbol : Top1
NCBI Gene ID : 32458
Species : Drosophila melanogaster
Gene Synonyms : CG6146 | CG6146-PA | CG6146-PB | CG6146-PC | CG6146-PD | Dmel_CG6146 | DmelCG6146 | dTopoI | l(1)G0134 | l(1)G0201 | l(1)G0229 | l(1)G0278 | l(1)top1 | TOP1 | Top1 | top1 | Top1-PA | Top1-PB | Top1-PC | Top1-PD | TopI | Topo I | topo I | TopoI | topoI | Topoisomerase 1 | topoisomerase 1 | Topoisomerase I | topoisomerase I | topoisomerase1 | type I topoisomerase
Source: [GPSDB icon]GPSDB
Gene Homologs : AgaP_AGAP004078 (Anopheles gambiae) | AGOS_ACL008C (Eremothecium gossypii) | AT5G55310.1 (Arabidopsis thaliana) | KLLA0C06116g (Kluyveromyces lactis) | MGG_09917 (Magnaporthe oryzae) | NCU09118 (Neurospora crassa) | Os08g0154600 (Oryza sativa) | top-1 (Caenorhabditis elegans) | TOP1 (Arabidopsis thaliana) | TOP1 (Bos taurus) | TOP1 (Canis lupus familiaris) | Top1 (Drosophila melanogaster) | TOP1 (Gallus gallus) | TOP1 (Homo sapiens) | TOP1 (Macaca mulatta) | Top1 (Mus musculus) | TOP1 (Pan troglodytes) | Top1 (Rattus norvegicus) | TOP1 (Saccharomyces cerevisiae) | top1 (Schizosaccharomyces pombe) | top1l (Danio rerio)
Ageing Relevance Analysis :
Observation Type Count Ageing Relevance Source
Homology Analysis 1 putative (Comp. Analysis) [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
Total 1
Ageing Factor Stable ID : AF_007714
Download : [xml icon]XML

Protein Information

Protein Name Species UniProt Accession Number UniProt Entry Name Protein Function Sequence
RE58921p Drosophila melanogaster [UniProtKB/TrEMBL icon]Q494M1 (UniProtKB/TrEMBL) [UniProtKB/TrEMBL icon]Q494M1_DROME (UniProtKB/TrEMBL) View
Topoisomerase 1, isoform B Drosophila melanogaster [UniProtKB/TrEMBL icon]Q8IR39 (UniProtKB/TrEMBL) [UniProtKB/TrEMBL icon]Q8IR39_DROME (UniProtKB/TrEMBL) View
DNA topoisomerase 1 Drosophila melanogaster [UniProtKB/Swiss-Prot icon]P30189 (UniProtKB/Swiss-Prot) [UniProtKB/Swiss-Prot icon]TOP1_DROME (UniProtKB/Swiss-Prot) Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. View

Observations

Ageing Phenotype

Data Type 1

no ageing phenotype observation—data type 1 available

Data Type 2

no ageing phenotype observation—data type 2 available

Homology Analysis

Ageing Relevance:
  • yes (Exp. Analysis)
  • yes, but no ageing factor assigned (Exp. Analysis)
  • no (Exp. Analysis)
  • putative (Comp. Analysis)
Legend:
#EGHG:
Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# Observation Stable ID Homology Group Genes #EGHG Description Source Homology Source
1 OB_008172
Gene Symbol Species NCBI Gene ID
AgaP_AGAP004078 Anopheles gambiae 1270877
AGOS_ACL008C Eremothecium gossypii 4619521
AT5G55310.1 Arabidopsis thaliana 835624
KLLA0C06116g Kluyveromyces lactis 2892647
MGG_09917 Magnaporthe oryzae 2680887
NCU09118 Neurospora crassa 3874180
Os08g0154600 Oryza sativa 4344685
top-1 Caenorhabditis elegans 266847
TOP1 Arabidopsis thaliana 835623
TOP1 Bos taurus 534799
TOP1 Canis lupus familiaris 477229
Top1 Drosophila melanogaster 32458
TOP1 Gallus gallus 396004
TOP1 Homo sapiens 7150
TOP1 Macaca mulatta 697300
Top1 Mus musculus 21969
TOP1 Pan troglodytes 458252
Top1 Rattus norvegicus 64550
TOP1 Saccharomyces cerevisiae 854156
top1 Schizosaccharomyces pombe 2540032
top1l Danio rerio 553496
3 The HomoloGene homology group 2467 contains 3 genes with experimental evidence for ageing relevance (TOP1 - Homo sapiens | TOP1 - Saccharomyces cerevisiae | top-1 - Caenorhabditis elegans) and 18 other genes. [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis [HomoloGene icon]HomoloGene homology group 2467

Sequences

[UniProtKB/TrEMBL icon]Q494M1_DROME | [UniProtKB/TrEMBL icon]Q494M1 | RE58921p (Drosophila melanogaster) from UniProtKB/TrEMBL  Length: 974

                                    10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420       430       440       450       460       470       480       490       500       510       520       530       540       550       560       570       580       590       600       610       620       630       640       650       660       670       680       690       700       710       720       730       740       750       760       770       780       790       800       810       820       830       840       850       860       870       880       890       900       910       920       930       940       950       960       970    
         Q494M1_DROME     1 MSGDVAAENSIHIQNGGSCEVVQSNGVTTNGHGHHHHHHHSSSSSSSSKHKSSSKDKHRDREREHKSSNSSSSSKEHKSSSRDKDRHKSSSSSSKHRDKDKERDGSSNSHRSGSSSSHKDKDGSSSSKHKSSSGHHKRSSKDKERRDKDKDRGSSSSSRHKSSSSSRDKERSSSSHKSSSSSSSSKSKHSSSRHSSSSSSKDQPSYDGVFVKPEPVSQQLMHSGSVDAFQMQQLGSYEAAAAGTNFNGNGNVAGANYKNGYEESIVDIKKEEESFNNLSQASSCDYSMSQFRADEPPFVVKHEQSYAEEDSTMNYNDHDDDADEMNDDEEDVPLAMRKRKQEATDRPDGGMDNDDDDDIPLLARKKVKKEKIKKESKEKSKKRVKEEPSDDYGNVKPKKKKMKKEPEPAVSPGKRQKAKAKVEEEEVWRWWEEEKRADGVKWSTLEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPREREIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEALMKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKVPSPPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVIDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQLHKELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDLFDRLNTQVLNEHLKELMEGLTAKVFRTYNASKTLQSQLDLLTDPSATVPEKLLAYNRANRAVAILCNHQRSVPKSHEKSMENLKEKIKAKREAIEKCESEYHSRDEKKGKQLERLRDQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWCKKHDVPIEKIFNKTQRTKFLWAVHMADENYRF 974


[UniProtKB/TrEMBL icon]Q8IR39_DROME | [UniProtKB/TrEMBL icon]Q8IR39 | Topoisomerase 1, isoform B (Drosophila melanogaster) from UniProtKB/TrEMBL  Length: 581

                                    10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420       430       440       450       460       470       480       490       500       510       520       530       540       550       560       570       580 
         Q8IR39_DROME     1 MPYNRKNFFCQEPEPAVSPGKRQKAKAKVEEEEVWRWWEEEKRADGVKWSTLEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPREREIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEALMKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKVPSPPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVIDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQLHKELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDLFDRLNTQVLNEHLKELMEGLTAKVFRTYNASKTLQSQLDLLTDPSATVPEKLLAYNRANRAVAILCNHQRSVPKSHEKSMENLKEKIKAKREAIEKCESEYHSRDEKKGKQLERLRDQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWCKKHDVPIEKIFNKTQRTKFLWAVHMADENYRF 581


[UniProtKB/Swiss-Prot icon]TOP1_DROME | [UniProtKB/Swiss-Prot icon]P30189 | DNA topoisomerase 1 (Drosophila melanogaster) from UniProtKB/Swiss-Prot  Length: 972

                                    10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420       430       440       450       460       470       480       490       500       510       520       530       540       550       560       570       580       590       600       610       620       630       640       650       660       670       680       690       700       710       720       730       740       750       760       770       780       790       800       810       820       830       840       850       860       870       880       890       900       910       920       930       940       950       960       970  
           TOP1_DROME     1 MSGDVAAENSIHIQNGGSCEVVQSNGVTTNGHGHHHHHHSSSSSSSKHKSSSKDKHRDREREHKSSNSSSSSKEHKSSSRDKDRHKSSSSSSKHRDKDKERDGSSNSHRSGSSSSHKDKDGSSSSKHKSSSGHHKRSSKDKERRDKDKDRGSSSSSRHKSSSSSRDKERSSSSHKSSSSSSSSKSKHSSSRHSSSSSSKDHPSYDGVFVKPEPVSQQLMHSGSVDAFQMQQLGSYEAAAAGTNFNGNGNVAGANYKNGYEESIVDIKKEEESFNNLSQASSCDYSMSQFRADEPPFVVKHEQSYAEEDSTMNYNDHDDDADEMNDDEEDVPLAMRKRKQEATDRPDGGMDNDDDDDIPLLARKKVKKEKIKKESKEKSKKRVKEEPSDDYGNVKPKKKKMKKEPEPAVSPGKRQKAKAKVEEEEVWRWWEEEKRADGVKWSTLEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPREREIIKDFRKCNFQEMFNYFQAESEKRKAASKEEKLIKKNENEALMKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKVPSPPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKVIDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHVQLHKELNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDLFDRLNTQVLNEHLKELMEGLTAKVFRTYNASKTLQSQLDLLTDPSATVPEKLLAYNRANRAVAILCNHQRSVPKSHEKSMENLKEKIKAKREAIEKCESEYHSRDEKKGKQLERLRDQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWCKKHDVPIEKIFNKTQRTKFLWAVHMADENYRF 972

References

no reference information available

Sources

Ageing-related Data Sources

  • AgeFactDB Homology Analysis

Additional Data Sources