Gene: Sirt6 - Drosophila melanogaster
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | Sirt6 | ||||||||||||||||||||||||
NCBI Gene ID | : | 41254 | ||||||||||||||||||||||||
Species | : | Drosophila melanogaster | ||||||||||||||||||||||||
Gene Synonyms | : | CG6284 | CG6284 gene product from transcript CG6284-RB | CG6284-PB | D.mel4 | Dmel_CG6284 | DmelCG6284 | dmSRT408 | dSIRT6 | Sirt6 | Sirt6-PB Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP001458 (Anopheles gambiae) | NCU07624 (Neurospora crassa) | Os04g0271000 (Oryza sativa) | SIRT6 (Bos taurus) | SIRT6 (Canis lupus familiaris) | sirt6 (Danio rerio) | Sirt6 (Drosophila melanogaster) | SIRT6 (Gallus gallus) | SIRT6 (Homo sapiens) | SIRT6 (Macaca mulatta) | Sirt6 (Mus musculus) | SIRT6 (Pan troglodytes) | Sirt6 (Rattus norvegicus) | SRT1 (Arabidopsis thaliana) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_007717 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
NAD-dependent protein deacetylase Sirt6 | Drosophila melanogaster | Q9VH08 (UniProtKB/Swiss-Prot) | SIR6_DROME (UniProtKB/Swiss-Prot) | NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_005933 | Drosophila melanogaster |
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Decreased expression by RNA interference caused lethality during development. Silencing in neurons shortened mean lifespan by 20%. | 17159295 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_003065 | Drosophila melanogaster |
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increased | 20.00% | mean | Silencing in neurons shortened mean lifespan by 20%. Other phenotypes: Decreased expression by RNA interference caused lethality during development. | Kusama et al. | 2006 | 17159295 | Lifespan Observations Database (ID: 4407) | ||||||||||||||||||||||||
2 | OB_005934 | Drosophila melanogaster |
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decreased | -20.00% | Average | Decreased expression by RNA interference caused lethality during development. Silencing in neurons shortened mean lifespan by 20%. | Kusama et al. | 2006 | 17159295 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008240 | 3 | The HomoloGene homology group 6924 contains 3 genes with experimental evidence for ageing relevance (SIRT6 - Homo sapiens | Sirt6 - Drosophila melanogaster | Sirt6 - Mus musculus) and 11 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 6924 |
Sequences
SIR6_DROME | Q9VH08 | NAD-dependent protein deacetylase Sirt6 (Drosophila melanogaster) from UniProtKB/Swiss-Prot Length: 317 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 SIR6_DROME 1 MSCNYADGLSAYDNKGILGAPESFDSDEVVAEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFRGPKGVWTLEEKGEKPDFNVSFDEARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQCKKCRRQFVSPSAVETVGQKSLQRACKSSMDSKGRSCRSGILYDNVLDWEHDLPENDLEMGVMHSTVADLNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQPTKHDKKANLIISSYVDVVLSKVCKLLGVEIPEYSEASDPTKQSKPMEWTIPTSNVNTFHRQYKKYVYFIYYLL 317
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Kusama S, Ueda R, Suda T, Nishihara S, Matsuura ET:
Involvement of Drosophila Sir2-like genes in the regulation of life span.
Genes Genet Syst. 2006; 81: 341-8.
PubMed (ID: 17159295)
MeSH Terms: Drosophila Proteins/genetics; Drosophila melanogaster/genetics; Histone Deacetylases/genetics; Longevity/genetics; Sirtuins/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot