Gene: DJ-1alpha - Drosophila melanogaster
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | DJ-1alpha | ||||||||||||||||||||||||
NCBI Gene ID | : | 36543 | ||||||||||||||||||||||||
Species | : | Drosophila melanogaster | ||||||||||||||||||||||||
Gene Synonyms | : | CG6646 | CG6646 gene product from transcript CG6646-RA | CG6646-PA | DJ-1 | DJ-1A | DJ-1a | DJ-1alpha | DJ-1alpha-PA | Dmel_CG6646 | DmelCG6646 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP000705 (Anopheles gambiae) | DJ-1alpha (Drosophila melanogaster) | dj-1beta (Drosophila melanogaster) | djr-1.1 (Caenorhabditis elegans) | djr-1.2 (Caenorhabditis elegans) | Os01g0217800 (Oryza sativa) | PARK7 (Bos taurus) | PARK7 (Canis lupus familiaris) | park7 (Danio rerio) | PARK7 (Gallus gallus) | PARK7 (Homo sapiens) | Park7 (Mus musculus) | PARK7 (Pan troglodytes) | Park7 (Rattus norvegicus) | SPAC22E12.03c (Schizosaccharomyces pombe) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_007737 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
DJ-1alpha | Drosophila melanogaster | A1Z9J4 (UniProtKB/TrEMBL) | A1Z9J4_DROME (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_007586 | Drosophila melanogaster |
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RNA interference shortened maximum lifespan by 13% and resulted in increased sensitivity to oxidative stress and motor impairments. | 17651920 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_007587 | Drosophila melanogaster |
|
decreased | -13.00% | maximum | RNA interference shortened maximum lifespan by 13% and resulted in increased sensitivity to oxidative stress and motor impairments. | Lavara-Culebras et al. | 2007 | 17651920 | doi:10.1016/j.gene.2007.06.013 | GenAge | |||||||||||||||||||||||
2 | OB_003017 | Drosophila melanogaster | DJ-1 |
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decreased | -55.26% | 17 | 38 | RNA interference shortened mean lifespan 55%/ | Lavara-Culebras et al. | 2007 | 17651920 | doi:10.1016/j.gene.2007.06.013 | Lifespan Observations Database (ID: 435) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008250 | 2 | The HomoloGene homology group 38295 contains 2 genes with experimental evidence for ageing relevance (DJ-1alpha - Drosophila melanogaster | dj-1beta - Drosophila melanogaster) and 13 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 38295 |
Sequences
A1Z9J4_DROME | A1Z9J4 | DJ-1alpha (Drosophila melanogaster) from UniProtKB/TrEMBL Length: 217 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 A1Z9J4_DROME 1 MLSVLRKSFPNGVTHAHRVIRCKSNQDKCAKNALIILAPGAEEMEFTISADVLRRGKILVTVAGLHDCEPVKCSRSVVIVPDTSLEEAVTRGDYDVVVLPGGLAGNKALMNSSAVGDVLRCQESKGGLIAAICAAPTALAKHGIGKGKSITSHPDMKPQLKELYCYIDDKTVVQDGNIITSRGPGTTFDFALKITEQLVGAEVAKEVAKAMLWTYKP 217
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Lavara-Culebras E, Paricio N:
Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits.
Gene. 2007; 400: 158-65.
PubMed (ID: 17651920), doi:10.1016/j.gene.2007.06.013
MeSH Terms: Drosophila Proteins/genetics; Life Expectancy; Motor Activity/genetics; Oxidative Stress
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/TrEMBL