Gene: mth - Drosophila melanogaster
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
mth |
NCBI Gene ID |
: |
38058 |
Species |
: |
Drosophila melanogaster |
Gene Synonyms |
: |
CG6936 | CG6936-PA | CG6936-PB | CG6936-PE | Dmel_CG6936 | DmelCG6936 | methusalah | Methuselah | methuselah | MTH | Mth | mth | mth-PA | mth-PB | mth-PE
Source: GPSDB |
Gene Homologs |
: |
mth (Drosophila melanogaster) | mthl10 (Drosophila melanogaster) | mthl11 (Drosophila melanogaster) | mthl12 (Drosophila melanogaster) | mthl13 (Drosophila melanogaster) | mthl2 (Drosophila melanogaster) | mthl3 (Drosophila melanogaster) | mthl4 (Drosophila melanogaster) | mthl6 (Drosophila melanogaster) | mthl7 (Drosophila melanogaster) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
increased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
3 |
|
|
|
Ageing Factor Stable ID |
: |
AF_007745 |
Download |
: |
XML |
Protein Information
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005590 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
mth |
38058 |
|
|
Mutants displayed approximately 35 percent increase in average lifespan and enhanced resistance to various forms of stress. |
9794765 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_003013 |
Drosophila melanogaster |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mth |
Drosophila melanogaster |
38058 |
loss of function |
- |
unknown |
unknown |
|
|
|
increased |
36.36% |
75 |
55 |
days |
mean |
25 |
℃ |
male |
Mutants displayed approximately 35 percent increase in average lifespan. Other phenotypes: Mutants displayed enhanced resistance to various forms of stress. |
Lin et al. |
1998 |
9794765 |
|
Lifespan Observations Database (ID: 4346) |
2 |
OB_005591 |
Drosophila melanogaster |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
mth |
Drosophila melanogaster |
38058 |
Mutation |
- |
wildtype |
yes |
|
|
|
increased |
35.00% |
|
|
|
unknown |
|
|
|
Mutants displayed approximately 35 percent increase in average lifespan and enhanced resistance to various forms of stress. |
Lin et al. |
1998 |
9794765 |
|
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_009088 |
|
1 |
The HomoloGene homology group 120037 contains 1 gene with experimental evidence for ageing relevance (mth - Drosophila melanogaster) and 9 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 120037 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Lin YJ, Seroude L, Benzer S:
Extended life-span and stress resistance in the Drosophila mutant methuselah.
Science. 1998; 282: 943-6.
PubMed (ID: 9794765)
MeSH Terms: Drosophila Proteins; Drosophila melanogaster/genetics; Drosophila melanogaster/physiology; GTP-Binding Proteins/genetics; Genes, Insect; Receptors, Cell Surface/genetics; Receptors, G-Protein-Coupled
Sources
Ageing-related Data Sources
Additional Data Sources