Gene: Eip71CD - Drosophila melanogaster
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
Eip71CD |
NCBI Gene ID |
: |
39675 |
Species |
: |
Drosophila melanogaster |
Gene Synonyms |
: |
CG7266 | CG7266-PA | CG7266-PB | CG7266-PC | CG7266-PE | CG7266-PF | CG7266-PG | Dmel_CG7266 | DmelCG7266 | dmsrA | DROZ60MEX | Ecdysone-induced protein 28/29kD | Eip28 | Eip28 /29 | Eip28/29 | eip28/29 | Eip71C | Eip71CD | Eip71CD-PA | Eip71CD-PB | Eip71CD-PC | Eip71CD-PE | Eip71CD-PF | Eip71CD-PG | methionine sulfoxide reductase A | methionine-S-sulfoxide reductase | MsrA
Source: GPSDB |
Gene Homologs |
: |
AgaP_AGAP012394 (Anopheles gambiae) | AgaP_AGAP012395 (Anopheles gambiae) | Eip71CD (Drosophila melanogaster) | msra-1 (Caenorhabditis elegans) | MSRA5 (Arabidopsis thaliana) | Os06g0138100 (Oryza sativa) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) putative (Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
2 |
|
|
|
Ageing Factor Stable ID |
: |
AF_007756 |
Download |
: |
XML |
Protein Information
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005583 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
Eip71CD |
39675 |
|
|
Overexpression in the nervous system extended lifespan by up to 70%, increased resistance to oxidative stress, and delayed the onset of senescence-induced decline in activity levels and reproductive capacity. |
11867705 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_005584 |
Drosophila melanogaster |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Eip71CD |
Drosophila melanogaster |
39675 |
Overexpression |
- |
wildtype |
yes |
|
|
|
increased |
70.00% |
|
|
|
unknown |
|
|
|
Overexpression in the nervous system extended lifespan by up to 70%, increased resistance to oxidative stress, and delayed the onset of senescence-induced decline in activity levels and reproductive capacity. |
Ruan et al. |
2002 |
11867705 |
doi:10.1073/pnas.032671199 |
GenAge |
2 |
OB_005585 |
Drosophila melanogaster |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Eip71CD |
Drosophila melanogaster |
39675 |
Overexpression |
- |
wildtype |
yes |
|
|
|
increased |
20.00% |
|
|
|
maximum |
|
|
|
Mean and maximal lifepsan was increased by up to 20% in flies with overexpressed Msra. |
Chung et al. |
2010 |
20655917 |
doi:10.1016/j.febslet.2010.07.033 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008703 |
|
2 |
The HomoloGene homology group 42309 contains 2 genes with experimental evidence for ageing relevance (Eip71CD - Drosophila melanogaster | msra-1 - Caenorhabditis elegans) and 4 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 42309 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Ruan H, Tang XD, Chen ML, Joiner ML, Sun G, Brot N, Weissbach H, Heinemann SH, Iverson L, Wu CF, Hoshi T, Chen ML, Joiner MA, Heinemann SH:
High-quality life extension by the enzyme peptide methionine sulfoxide reductase.
Proc Natl Acad Sci USA. 2002; 99: 2748-53.
PubMed (ID: 11867705), PubMed Central (ID: PMC122419), doi:10.1073/pnas.032671199
MeSH Terms: Longevity/physiology; Oxidoreductases/physiology
- Chung H, Kim AK, Jung SA, Kim SW, Yu K, Lee JH:
The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO.
FEBS Lett. 2010; 584: 3609-14.
PubMed (ID: 20655917), doi:10.1016/j.febslet.2010.07.033
MeSH Terms: Drosophila Proteins/metabolism; Drosophila melanogaster/metabolism; Forkhead Transcription Factors/metabolism; Methionine Sulfoxide Reductases/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources