Gene: Ef1alpha48D - Drosophila melanogaster
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | Ef1alpha48D | ||||||||||||||||||||||||
NCBI Gene ID | : | 36271 | ||||||||||||||||||||||||
Species | : | Drosophila melanogaster | ||||||||||||||||||||||||
Gene Synonyms | : | CG8280 | CG8280-PA | CG8280-PC | clone 1.17 | clone 2.46 | Dm0084 | DmEF1 | Dmel_CG8280 | DmelCG8280 | eEF1alpha | EF | EF-1 | EF-1[a] | EF-1a | EF-1alpha | ef-1alpha | EF-1alpha F1 | EF-1alphaF | EF-1alphaF1 | EF-1alphaF[[1]] | EF1-alpha | EF11_DROME | Ef1a10 | Ef1a48D | EF1alpha | EF1alpha 48D | Ef1alpha1 | EF1alpha48D | Ef1alpha48D | Ef1alpha48D-PA | Ef1alpha48D-PC | Ef1alpha48E | EF1B | Efalpha48D | Elongation factor 1 alpha | elongation factor 1 alpha | Elongation factor 1 alpha 48D | elongation factor 1 alpha 48D | elongation factor 1-alpha F1 | Elongation factor 1alpha48D | elongation factor 1alpha48D | F1 | F1 EF-1alpha | l(2)01275 | l(2)1275 | l(2)k07303 | Translational elongation factor1 | translational elongation factor1 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP007406 (Anopheles gambiae) | AGOS_ADL370C (Eremothecium gossypii) | eef-1A.1 (Caenorhabditis elegans) | eef-1A.2 (Caenorhabditis elegans) | eef1a (Danio rerio) | EEF1A1 (Bos taurus) | EEF1A1 (Canis lupus familiaris) | EEF1A1 (Gallus gallus) | EEF1A1 (Homo sapiens) | EEF1A1 (Macaca mulatta) | EEF1A1 (Pan troglodytes) | eef1a1l2 (Danio rerio) | ef1a-b (Schizosaccharomyces pombe) | ef1a-c (Schizosaccharomyces pombe) | Ef1alpha48D (Drosophila melanogaster) | KLLA0B08998g (Kluyveromyces lactis) | LOC100360413 (Rattus norvegicus) | MGG_03641 (Magnaporthe oryzae) | NCU02003 (Neurospora crassa) | TEF1 (Saccharomyces cerevisiae) | tef1a (Schizosaccharomyces pombe) | TEF2 (Saccharomyces cerevisiae) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_007796 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Elongation factor 1-alpha | Drosophila melanogaster | C6TP87 (UniProtKB/TrEMBL) | C6TP87_DROME (UniProtKB/TrEMBL) | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. | View |
Elongation factor 1-alpha 1 | Drosophila melanogaster | P08736 (UniProtKB/Swiss-Prot) | EF1A1_DROME (UniProtKB/Swiss-Prot) | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_007632 | Drosophila melanogaster |
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increased | 41.00% | unknown | Overexpression results in lifespan extension by 18%-41%. | Shepherd et al. | 1989 | 2508089 | GenAge | ||||||||||||||||||||||||
2 | OB_003110 | Drosophila melanogaster |
|
increased | 30.00% | Overexpression results in lifespan extension by 18%-41%. | Shepherd et al. | 1989 | 2508089 | Lifespan Observations Database (ID: 448) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
Sequences
C6TP87_DROME | C6TP87 | Elongation factor 1-alpha (Drosophila melanogaster) from UniProtKB/TrEMBL Length: 463 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 C6TP87_DROME 1 MGKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQTREHALLAFTLGVKQLIVGVNKMDSSEPPYSEARYEEIKKEVSSYIKKIGYNPAAVAFVPISGWHGDNMLEPSTNMPWFKGWKVERKEGNADGKTLIDALDAILPPARPTDKALRLPLQDVYKIGGIGTVPVGRVETGVLKPGTVVVFAPANITTEVKSVEMHHEALQEAVPGDNVGFNVKNVSVKELRRGYVAGDSKANPPKGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFAEIKEKVDRRSGKTTEENPKFIKSGDAAIVNLVPSKPLCVEAFQEFPPLGRFAVRDMRQTVAVGVIKAVNFKDASGGKVTKAAEKATKGKK 463
EF1A1_DROME | P08736 | Elongation factor 1-alpha 1 (Drosophila melanogaster) from UniProtKB/Swiss-Prot Length: 463 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 EF1A1_DROME 1 MGKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQTREHALLAFTLGVKQLIVGVNKMDSSEPPYSEARYEEIKKEVSSYIKKIGYNPAAVAFVPISGWHGDNMLEPSTNMPWFKGWKVERKEGNADGKTLIDALDAILPPARPTDKALRLPLQDVYKIGGIGTVPVGRVETGVLKPGTVVVFAPANITTEVKSVEMHHEALQEAVPGDNVGFNVKNVSVKELRRGYVAGDSKANPPKGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFAEIKEKVDRRSGKTTEENPKFIKSGDAAIVNLVPSKPLCVEAFQEFPPLGRFAVRDMRQTVAVGVIKAVNFKDASGGKVTKAAEKATKGKK 463
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Shepherd JC, Walldorf U, Hug P, Gehring WJ:
Fruit flies with additional expression of the elongation factor EF-1 alpha live longer.
Proc Natl Acad Sci USA. 1989; 86: 7520-1.
PubMed (ID: 2508089), PubMed Central (ID: PMC298096)
MeSH Terms: Drosophila melanogaster/genetics; Eukaryotic Initiation Factor-1/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- UniProtKB/Swiss-Prot
- UniProtKB/TrEMBL
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed