Gene: Chek2 - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
Chek2 |
NCBI Gene ID |
: |
50883 |
Species |
: |
Mus musculus |
Gene Synonyms |
: |
Cds1 | Cds1 homolog | checkpoint kinase 2 | Chek2 | CHK2 | Chk2 | CHK2 checkpoint homolog | HUCDS1 | protein kinase Chk2 | Rad53 | Rad53 homolog | serine/threonine-protein kinase Chk2
Source: GPSDB |
Gene Homologs |
: |
AgaP_AGAP009784 (Anopheles gambiae) | CELE_T08D2.7 (Caenorhabditis elegans) | CHEK2 (Bos taurus) | CHEK2 (Canis lupus familiaris) | chek2 (Danio rerio) | CHEK2 (Gallus gallus) | CHEK2 (Homo sapiens) | CHEK2 (Macaca mulatta) | Chek2 (Mus musculus) | CHEK2 (Pan troglodytes) | Chek2 (Rattus norvegicus) | chk-2 (Caenorhabditis elegans) | lok (Drosophila melanogaster) | MGG_01596 (Magnaporthe oryzae) | NCU02814 (Neurospora crassa) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
increased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) putative (Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
3 |
|
|
|
Ageing Factor Stable ID |
: |
AF_007978 |
Download |
: |
XML |
Protein Information
Protein Name |
Species |
UniProt Accession Number |
UniProt Entry Name |
Protein Function |
Sequence |
Serine/threonine-protein kinase Chk2 |
Mus musculus |
Q9Z265 (UniProtKB/Swiss-Prot) |
CHK2_MOUSE (UniProtKB/Swiss-Prot) |
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. |
View |
Putative uncharacterized protein |
Mus musculus |
Q543W6 (UniProtKB/TrEMBL) |
Q543W6_MOUSE (UniProtKB/TrEMBL) |
|
View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_006769 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Chek2 |
50883 |
|
|
Mice hypomorphic for Brca1 and double mutant for chk2 exhibit signs of premature ageing. |
16675955 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_000777 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Chek2 |
Mus musculus |
50883 |
loss of function |
- |
unknown |
unknown |
|
|
|
increased |
240.00% |
|
|
|
mean |
|
|
female |
Double mutants for chk2 extend lifespan of female mice hyopmorphic for Brca1 by at least 240%. Mice hypomorphic for Brca1 and double mutant for chk2 exhibit signs of premature ageing. |
Cao et al. |
2006 |
16675955 |
doi:10.1038/sj.emboj.7601115 |
Lifespan Observations Database (ID: 2036) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008257 |
|
2 |
The HomoloGene homology group 38289 contains 2 genes with experimental evidence for ageing relevance (CHEK2 - Homo sapiens | Chek2 - Mus musculus) and 13 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 38289 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Cao L, Kim S, Xiao C, Wang RH, Coumoul X, Wang X, Li WM, Xu XL, De Soto JA, Takai H, Mai S, Elledge SJ, Motoyama N, Deng CX:
ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency.
EMBO J. 2006; 25: 2167-77.
PubMed (ID: 16675955), PubMed Central (ID: PMC1462967), doi:10.1038/sj.emboj.7601115
MeSH Terms: BRCA1 Protein/metabolism; Cell Cycle Proteins/metabolism; DNA-Binding Proteins/metabolism; Homeostasis; Neoplasms/metabolism; Protein-Serine-Threonine Kinases/metabolism; Tumor Suppressor Protein p53/metabolism; Tumor Suppressor Proteins/metabolism
Sources
Ageing-related Data Sources
Additional Data Sources