Gene: CHL1 - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | CHL1 | ||||||||||||||||||||||||
NCBI Gene ID | : | 856099 | ||||||||||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||||||||||
Gene Synonyms | : | CHL1 | Chl1p | CTF1 | LPA9 | MCM12 | YP8132.05 | YPL008W Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP001537 (Anopheles gambiae) | AGOS_AGL010W (Eremothecium gossypii) | AT1G79890.1 (Arabidopsis thaliana) | CG11403 (Drosophila melanogaster) | chl-1 (Caenorhabditis elegans) | CHL1 (Saccharomyces cerevisiae) | chl1 (Schizosaccharomyces pombe) | DDX11 (Canis lupus familiaris) | ddx11 (Danio rerio) | DDX11 (Gallus gallus) | DDX11 (Homo sapiens) | Ddx11 (Mus musculus) | DDX11 (Pan troglodytes) | Ddx11 (Rattus norvegicus) | KLLA0F27181g (Kluyveromyces lactis) | LOC717040 (Macaca mulatta) | MGG_13542 (Magnaporthe oryzae) | NCU11409 (Neurospora crassa) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_007982 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_006828 | Saccharomyces cerevisiae |
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It may modulate transcriptional silencing in the presence of Sir proteins. Knockouts exhibit a shortened lifespan and are hypersensitivity to heat stress. | 16182251 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_006830 | Saccharomyces cerevisiae |
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decreased | -15.00% | unknown | Mean chronological lifespan decreased in the a strain by less than 50% but more than 15% | Laschober et al. | 2010 | 20883526 | doi:10.1111/j.1474-9726.2010.00637.x | GenAge | |||||||||||||||||||||||
2 | OB_000778 | Saccharomyces cerevisiae | AP22Dchl1 |
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decreased | -36.00% | 16 | 25 | divisions | mean | Knockouts exhibit a 36% shortened lifespan. Also show hypersensitivity to heat stress. It may modulate transcriptional silencing in the presence of Sir proteins. | Das et al. | 2005 | 16182251 | doi:10.1016/j.bbrc.2005.09.034 | Lifespan Observations Database (ID: 2037) | |||||||||||||||||||
3 | OB_006829 | Saccharomyces cerevisiae |
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decreased | unknown | It may modulate transcriptional silencing in the presence of Sir proteins. Knockouts exhibit a shortened lifespan and are hypersensitivity to heat stress. | Das et al. | 2005 | 16182251 | doi:10.1016/j.bbrc.2005.09.034 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008216 | 1 | The HomoloGene homology group 68973 contains 1 gene with experimental evidence for ageing relevance (CHL1 - Saccharomyces cerevisiae) and 17 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 68973 |
Sequences
no sequence information available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Das SP, Sinha P:
The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging.
Biochem Biophys Res Commun. 2005; 337: 167-72.
PubMed (ID: 16182251), doi:10.1016/j.bbrc.2005.09.034
MeSH Terms: Chromosomal Proteins, Non-Histone/physiology; DNA, Ribosomal/genetics; Gene Silencing; Saccharomyces cerevisiae Proteins/physiology; Saccharomyces cerevisiae/genetics; Sister Chromatid Exchange - Laschober GT, Ruli D, Hofer E, Muck C, Carmona-Gutierrez D, Ring J, Hutter E, Ruckenstuhl C, Micutkova L, Brunauer R, Jamnig A, Trimmel D, Herndler-Brandstetter D, Brunner S, Zenzmaier C, Sampson N, Breitenbach M, Fröhlich KU, Grubeck-Loebenstein B, Berger P, Wieser M, Grillari-Voglauer R, Thallinger GG, Grillari J, Trajanoski Z, Madeo F, Lepperdinger G, Jansen-Dürr P:
Identification of evolutionarily conserved genetic regulators of cellular aging.
Aging Cell. 2010; 9: 1084-97.
PubMed (ID: 20883526), PubMed Central (ID: PMC2997327), doi:10.1111/j.1474-9726.2010.00637.x
MeSH Terms: Cell Aging/genetics; Evolution, Molecular; Gene Expression Regulation
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed