Gene: CIT2 - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | CIT2 | ||||||||||||||||||||||||
NCBI Gene ID | : | 850361 | ||||||||||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||||||||||
Gene Synonyms | : | CIT2 | Cit2p | citrate (Si)-synthase CIT2 | YCR005C | YCR043 | YCR5C Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP012048 (Anopheles gambiae) | CIT2 (Saccharomyces cerevisiae) | CS (Bos taurus) | CS (Canis lupus familiaris) | cs (Danio rerio) | CS (Homo sapiens) | Cs (Mus musculus) | CS (Pan troglodytes) | Cs (Rattus norvegicus) | CSY4 (Arabidopsis thaliana) | cts-1 (Caenorhabditis elegans) | kdn (Drosophila melanogaster) | LOC100536541 (Danio rerio) | LOC100858903 (Gallus gallus) | LOC709604 (Macaca mulatta) | Os02g0194100 (Oryza sativa) | Os11g0538900 (Oryza sativa) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_008011 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_000101 | Saccharomyces cerevisiae | YPK9 |
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none | -1.10% | 18 | 18.2 | divisions | mean | 30 | ℃ | mata | Deletion of CIT2 has no effect on life-span. Other phenotypes: Overexpression of CIT2 has no effect on life-span [ 10224252]. CIT2 is not required for the strain specific life-span extension in petite cells. CIT2 is transcribed up to 30-fold higher in petite cells relative to grande cells [ 1986232]. | Kirchman et al. | 1999 | 10224252 | Lifespan Observations Database (ID: 110) | |||||||||||||||||
2 | OB_000097 | Saccharomyces cerevisiae | YPK9 |
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none | . Overexpression of CIT2 has no effect on life-span. Other phenotypes: Deletion of CIT2 has no effect on life-span [ 10224252]. CIT2 is not required for the strain specific life-span extension in petite cells. Overexpression of CIT2 has no effect on life-span [ 10224252]. CIT2 is transcribed up to 30-fold higher in petite cells relative to grande cells [ 1986232]. | Kirchman et al. | 1999 | 10224252 | Lifespan Observations Database (ID: 109) | |||||||||||||||||||||||||
3 | OB_006868 | Saccharomyces cerevisiae |
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decreased | unknown | Mean chronological lifespan strongly decreased in the a strain | Matecic et al. | 2010 | 20421943 | doi:10.1371/journal.pgen.1000921 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_009333 | 1 | The HomoloGene homology group 56073 contains 1 gene with experimental evidence for ageing relevance (CIT2 - Saccharomyces cerevisiae) and 16 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 56073 |
Sequences
no sequence information available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Kirchman PA, Kim S, Lai CY, Jazwinski SM:
Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae.
Genetics. 1999; 152: 179-90.
PubMed (ID: 10224252), PubMed Central (ID: PMC1460582)
MeSH Terms: Cell Nucleus/metabolism; Mitochondria/metabolism; Organelles/physiology; Saccharomyces cerevisiae/physiology; Signal Transduction - Matecic M, Smith DL, Pan X, Maqani N, Bekiranov S, Boeke JD, Smith JS:
A microarray-based genetic screen for yeast chronological aging factors.
PLoS Genet. 2010; 6: e1000921.
PubMed (ID: 20421943), PubMed Central (ID: PMC2858703), doi:10.1371/journal.pgen.1000921
MeSH Terms: Oligonucleotide Array Sequence Analysis; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/physiology
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed