Gene: EXOSC5 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | EXOSC5 | ||||||||||||
NCBI Gene ID | : | 56915 | ||||||||||||
Species | : | Homo sapiens | ||||||||||||
Gene Synonyms | : | chronic myelogenous leukemia tumor antigen 28 | CML28 | EXOSC5 | exosome complex component RRP46 | exosome complex exonuclease RRP46 | EXOSOME COMPONENT 5 | exosome component 5 | exosome component Rrp46 | hRrp46p | p12B | ribosomal RNA-processing protein 46 | RIBOSOMAL RNA-PROCESSING PROTEIN 46, S. CEREVISIAE, HOMOLOG OF | RRP41B | RRP46 | Rrp46p Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP002177 (Anopheles gambiae) | AGOS_AAR035C (Eremothecium gossypii) | AT3G46210.1 (Arabidopsis thaliana) | crn-5 (Caenorhabditis elegans) | EXOSC5 (Bos taurus) | EXOSC5 (Canis lupus familiaris) | exosc5 (Danio rerio) | EXOSC5 (Homo sapiens) | EXOSC5 (Macaca mulatta) | Exosc5 (Mus musculus) | EXOSC5 (Pan troglodytes) | Exosc5 (Rattus norvegicus) | KLLA0D14993g (Kluyveromyces lactis) | LOC100858931 (Gallus gallus) | MGG_09936 (Magnaporthe oryzae) | NCU03268 (Neurospora crassa) | Os03g0854200 (Oryza sativa) | Rrp46 (Drosophila melanogaster) | RRP46 (Saccharomyces cerevisiae) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_008038 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Exosome complex component RRP46 | Homo sapiens | Q9NQT4 (UniProtKB/Swiss-Prot) | EXOS5_HUMAN (UniProtKB/Swiss-Prot) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
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1 | OB_008170 | 1 | The HomoloGene homology group 5981 contains 1 gene with experimental evidence for ageing relevance (crn-5 - Caenorhabditis elegans) and 18 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 5981 |
Sequences
EXOS5_HUMAN | Q9NQT4 | Exosome complex component RRP46 (Homo sapiens) from UniProtKB/Swiss-Prot Length: 235 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 EXOS5_HUMAN 1 MEEETHTDAKIRAENGTGSSPRGPGCSLRHFACEQNLLSRPDGSASFLQGDTSVLAGVYGPAEVKVSKEIFNKATLEVILRPKIGLPGVAEKSRERLIRNTCEAVVLGTLHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVPMRALFCGVACALDSDGTLVLDPTSKQEKEARAVLTFALDSVERKLLMSSTKGLYSDTELQQCLAAAQAASQHVFRFYRESLQRRYSKS 235
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- UniProtKB/Swiss-Prot