Gene: PARK7 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | PARK7 | ||||||||||||
NCBI Gene ID | : | 11315 | ||||||||||||
Species | : | Homo sapiens | ||||||||||||
Gene Synonyms | : | CTA-215D11.1 | DJ-1 | DJ1 | ONCOGENE DJ1 | oncogene DJ1 | PARK7 | PARK7 GENE | Parkinson disease (autosomal recessive, early onset) 7 | parkinson protein 7 | protein DJ-1 Source: GPSDB |
||||||||||||
Gene Homologs | : | AgaP_AGAP000705 (Anopheles gambiae) | DJ-1alpha (Drosophila melanogaster) | dj-1beta (Drosophila melanogaster) | djr-1.1 (Caenorhabditis elegans) | djr-1.2 (Caenorhabditis elegans) | Os01g0217800 (Oryza sativa) | PARK7 (Bos taurus) | PARK7 (Canis lupus familiaris) | park7 (Danio rerio) | PARK7 (Gallus gallus) | PARK7 (Homo sapiens) | Park7 (Mus musculus) | PARK7 (Pan troglodytes) | Park7 (Rattus norvegicus) | SPAC22E12.03c (Schizosaccharomyces pombe) | ||||||||||||
Ageing Relevance Analysis | : |
|
||||||||||||
Ageing Factor Stable ID | : | AF_008113 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Protein DJ-1 | Homo sapiens | Q99497 (UniProtKB/Swiss-Prot) | PARK7_HUMAN (UniProtKB/Swiss-Prot) | Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008250 | 2 | The HomoloGene homology group 38295 contains 2 genes with experimental evidence for ageing relevance (DJ-1alpha - Drosophila melanogaster | dj-1beta - Drosophila melanogaster) and 13 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 38295 |
Sequences
PARK7_HUMAN | Q99497 | Protein DJ-1 (Homo sapiens) from UniProtKB/Swiss-Prot Length: 189 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 PARK7_HUMAN 1 MASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIVEALNGKEVAAQVKAPLVLKD 189
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- UniProtKB/Swiss-Prot