1 |
OB_000866 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Reduced glucose in the medium to 0.05% |
|
increased |
328.57% |
30 |
7 |
days |
median |
30 |
℃ |
matalpha |
Deletion of sir2, hst1, hst2, hst3, hst4 or all 5 sirtuins at the same time had no effect on chronological life span and did not reduce life span extension from dietary restriction at 0.5% or 0.05% glucose. |
Murakami et al. |
2008 |
18314444 |
|
Lifespan Observations Database (ID: 2171) |
2 |
OB_000881 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Reduced glucose in the medium to 0.05% |
|
increased |
257.14% |
25 |
7 |
days |
median |
30 |
℃ |
matalpha |
Deletion of sir2, hst1, hst2, hst3, hst4 or all 5 sirtuins at the same time had no effect on chronological life span and did not reduce life span extension from dietary restriction at 0.5% or 0.05% glucose. |
Murakami et al. |
2008 |
18314444 |
|
Lifespan Observations Database (ID: 2187) |
3 |
OB_000867 |
Saccharomyces cerevisiae |
PSY316AR |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Reduced glucose in the medium to 0.05% |
|
increased |
160.00% |
13 |
5 |
days |
median |
30 |
℃ |
matalpha |
Deletion of sir2, hst1, hst2, hst3, hst4 or all 5 sirtuins at the same time had no effect on chronological life span and did not reduce life span extension from dietary restriction at 0.5% or 0.05% glucose. |
Murakami et al. |
2008 |
18314444 |
|
Lifespan Observations Database (ID: 2172) |
4 |
OB_000868 |
Saccharomyces cerevisiae |
PSY316AR |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Reduced glucose in the medium to 0.5% |
|
increased |
160.00% |
13 |
5 |
days |
median |
30 |
℃ |
matalpha |
Deletion of sir2, hst1, hst2, hst3, hst4 or all 5 sirtuins at the same time had no effect on chronological life span and did not reduce life span extension from dietary restriction at 0.5% or 0.05% glucose. |
Murakami et al. |
2008 |
18314444 |
|
Lifespan Observations Database (ID: 2173) |
5 |
OB_000869 |
Saccharomyces cerevisiae |
W303AR5 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Reduced glucose in the medium to 0.5% |
|
increased |
140.00% |
12 |
5 |
days |
median |
30 |
℃ |
mata |
Deletion of sir2, hst1, hst2, hst3, hst4 or all 5 sirtuins at the same time had no effect on chronological life span and did not reduce life span extension from dietary restriction at 0.5% or 0.05% glucose. |
Murakami et al. |
2008 |
18314444 |
|
Lifespan Observations Database (ID: 2174) |
6 |
OB_000870 |
Saccharomyces cerevisiae |
W303AR5 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Reduced glucose in the medium to 0.05% |
|
increased |
140.00% |
12 |
5 |
days |
median |
30 |
℃ |
mata |
Deletion of sir2, hst1, hst2, hst3, hst4 or all 5 sirtuins at the same time had no effect on chronological life span and did not reduce life span extension from dietary restriction at 0.5% or 0.05% glucose. |
Murakami et al. |
2008 |
18314444 |
|
Lifespan Observations Database (ID: 2175) |
7 |
OB_000865 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Reduced glucose in the medium to 0.5% |
|
increased |
128.57% |
16 |
7 |
days |
median |
30 |
℃ |
matalpha |
Deletion of sir2, hst1, hst2, hst3, hst4 or all 5 sirtuins at the same time had no effect on chronological life span and did not reduce life span extension from dietary restriction at 0.5% or 0.05% glucose. |
Murakami et al. |
2008 |
18314444 |
|
Lifespan Observations Database (ID: 2170) |
8 |
OB_004199 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
GPA2 |
Saccharomyces cerevisiae |
856741 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
92.45% |
51 |
26.5 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of GPA2 significantly increased the life span of SIR2 FOB1 double mutants in the BY4742. The SIR2 FOB1 GPA2 triple mutant was approximately 90% longer-lived than wild type cells. |
Kaeberlein et al. |
2004 |
15328540 |
doi:10.1371/journal.pbio.0020296 |
Lifespan Observations Database (ID: 887) |
9 |
OB_000155 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
increased |
76.63% |
46.1 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1167) |
10 |
OB_000116 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.005% glucose |
|
increased |
76.52% |
43.6 |
24.7 |
|
|
30 |
℃ |
matalpha |
Dietary restriction at 0.5%, 0.05%, or 0.005% glucose significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from dietary restriction. |
Kaeberlein et al. |
2006 |
16741098 |
doi:10.1126/science.1124608 |
Lifespan Observations Database (ID: 1126) |
11 |
OB_000151 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
increased |
75.86% |
45.9 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1163) |
12 |
OB_000117 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
HXK2 |
Saccharomyces cerevisiae |
852639 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
70.82% |
43.9 |
25.7 |
|
|
30 |
℃ |
matalpha |
Deletion of HXK2 significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from deletion of HXK2. Deletion of HXK2 is proposed as a genetic mimic of dietary restriction [ 11000115]. |
Kaeberlein et al. |
2006 |
16741098 |
doi:10.1126/science.1124608 |
Lifespan Observations Database (ID: 1127) |
13 |
OB_004198 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HXK2 |
Saccharomyces cerevisiae |
852639 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
70.57% |
45.2 |
26.5 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of HXK2 significantly increased the life span of SIR2 FOB1 double mutants in the BY4742. The SIR2 FOB1 HXK2 triple mutant was approximately 70% longer-lived than wild type cells.. |
Kaeberlein et al. |
2004 |
15328540 |
doi:10.1371/journal.pbio.0020296 |
Lifespan Observations Database (ID: 886) |
14 |
OB_000115 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
increased |
70.45% |
42.1 |
24.7 |
|
|
30 |
℃ |
matalpha |
Dietary restriction at 0.5%, 0.05%, or 0.005% glucose significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from dietary restriction. |
Kaeberlein et al. |
2006 |
16741098 |
doi:10.1126/science.1124608 |
Lifespan Observations Database (ID: 1125) |
15 |
OB_004210 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
increased |
69.35% |
42 |
24.8 |
divisions |
mean |
30 |
℃ |
matalpha |
Dietary restriction by reducing the glucose of the media from 2% to 0.05% significantly increases the life span of sir2 fob1 double mutant cells. |
Kaeberlein et al. |
2004 |
15328540 |
doi:10.1371/journal.pbio.0020296 |
Lifespan Observations Database (ID: 901) |
16 |
OB_000144 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
increased |
68.20% |
43.9 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1157) |
17 |
OB_000161 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.005% glucose |
|
increased |
67.05% |
43.6 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1172) |
18 |
OB_004211 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.1% glucose |
|
increased |
64.52% |
40.8 |
24.8 |
divisions |
mean |
30 |
℃ |
matalpha |
Dietary restriction by reducing the glucose of the media from 2% to 0.1% significantly increases the life span of sir2 fob1 double mutant cells. |
Kaeberlein et al. |
2004 |
15328540 |
doi:10.1371/journal.pbio.0020296 |
Lifespan Observations Database (ID: 902) |
19 |
OB_004215 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
over-expression |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
increased |
62.07% |
42.3 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Overexpression of SIR2 combined with dietary restriction by reducing the glucose in the media from 2% to 0.05% significantly increased the life span of BY4742 mother cells beyond that of cells overexpressing SIR2 or cells subjected to dietary restriction alone. |
Kaeberlein et al. |
2004 |
15328540 |
doi:10.1371/journal.pbio.0020296 |
Lifespan Observations Database (ID: 906) |
20 |
OB_000160 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
increased |
61.30% |
42.1 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1171) |
21 |
OB_000110 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
increased |
61.17% |
44 |
27.3 |
divisions |
mean |
30 |
℃ |
matalpha |
Addition of 5 mM nicotinamide has no effect on replicative life span in BY4742 sir2 fob1 double mutant cells. Dietary restriction is still able to increase life span of sir2 fob1 double mutant cells treated with 5 mM nicotinamide. These data demonstrate that SIR2 and other nicotinamide-sensitive sirtuins are not required for life span extension from dietary restriction in the BY4742 strain background. |
Kaeberlein et al. |
2005 |
16311627 |
doi:10.1371/journal.pgen.0010069 |
Lifespan Observations Database (ID: 1120) |
22 |
OB_000145 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.005% glucose |
|
increased |
57.09% |
41 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1158) |
23 |
OB_000150 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
increased |
53.64% |
40.1 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1162) |
24 |
OB_000095 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SCH9 |
Saccharomyces cerevisiae |
856612 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
49.39% |
36.6 |
24.5 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of TOR or SCH9 increase life span of sir2 fob1 double mutant cells. SIR2 and FOB1 are believed to act in a single genetic pathway to promote replicative life span by reducing the accumulation of extrachromosomal rDNA circles in the mother cell [ 10521401]. Since dietary restriction also increases the life span of sir2 fob1 double mutant cells [ 15328540], this supports the model that TOR1, SCH9, and dietary restriction act in a single pathway that is distinct from SIR2, FOB1, and extrachromosomal rDNA circles. |
Kaeberlein et al. |
2005 |
16293764 |
doi:10.1126/science.1115535 |
Lifespan Observations Database (ID: 1094) |
25 |
OB_002437 |
Saccharomyces cerevisiae |
W303AR5 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
over-expression |
- |
unknown |
unknown |
|
|
|
increased |
34.68% |
29.9 |
22.2 |
divisions |
mean |
30 |
℃ |
mata |
Single copy overexpression of SIR2 or deletion of FOB1 extends life span in W303AR5. Combining SIR2 overexpression with deletion of FOB1 has no further effect on life span, consistent with the model that SIR2 and FOB1 act antagonistically in the same pathway to modulate replicative life span. |
Kaeberlein et al. |
1999 |
10521401 |
|
Lifespan Observations Database (ID: 36) |
26 |
OB_000094 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
33.47% |
32.7 |
24.5 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of TOR or SCH9 increase life span of sir2 fob1 double mutant cells. SIR2 and FOB1 are believed to act in a single genetic pathway to promote replicative life span by reducing the accumulation of extrachromosomal rDNA circles in the mother cell [ 10521401]. Since dietary restriction also increases the life span of sir2 fob1 double mutant cells [ 15328540], this supports the model that TOR1, SCH9, and dietary restriction act in a single pathway that is distinct from SIR2, FOB1, and extrachromosomal rDNA circles. |
Kaeberlein et al. |
2005 |
16293764 |
doi:10.1126/science.1115535 |
Lifespan Observations Database (ID: 1093) |
27 |
OB_004207 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.5% glucose |
|
increased |
32.66% |
32.9 |
24.8 |
divisions |
mean |
30 |
℃ |
matalpha |
Dietary restriction by reducing the glucose of the media from 2% to 0.5% significantly increases the life span of sir2 fob1 double mutant cells. |
Kaeberlein et al. |
2004 |
15328540 |
doi:10.1371/journal.pbio.0020296 |
Lifespan Observations Database (ID: 897) |
28 |
OB_004214 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
over-expression |
- |
unknown |
unknown |
|
|
|
increased |
32.57% |
34.6 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Overexpression of SIR2 significantly increased the life span of BY4742 mother cells. |
Kaeberlein et al. |
2004 |
15328540 |
doi:10.1371/journal.pbio.0020296 |
Lifespan Observations Database (ID: 905) |
29 |
OB_000529 |
Saccharomyces cerevisiae |
W303AR5 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
over-expression |
- |
unknown |
unknown |
|
|
|
increased |
32.43% |
29.4 |
22.2 |
|
mean |
30 |
℃ |
mata |
Single copy overexpression of SIR2 or deletion of FOB1 extends life span in W303AR5. Combining SIR2 overexpression with deletion of FOB1 has no further effect on life span, consistent with the model that SIR2 and FOB1 act antagonistically in the same pathway to modulate replicative life span. |
Kaeberlein et al. |
1999 |
10521401 |
|
Lifespan Observations Database (ID: 1790) |
30 |
OB_000148 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
increased |
31.03% |
34.2 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1160) |
31 |
OB_005917 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
Overexpression |
- |
wildtype |
yes |
|
|
|
increased |
30.00% |
|
|
|
unknown |
|
|
|
Overexpression extended lifespan by about 30%. |
Kaeberlein et al. |
1999 |
10521401 |
|
GenAge |
32 |
OB_000163 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
increased |
29.89% |
33.9 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1174) |
33 |
OB_000114 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.5% glucose |
|
increased |
26.72% |
31.3 |
24.7 |
|
|
30 |
℃ |
matalpha |
Dietary restriction at 0.5%, 0.05%, or 0.005% glucose significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from dietary restriction. |
Kaeberlein et al. |
2006 |
16741098 |
doi:10.1126/science.1124608 |
Lifespan Observations Database (ID: 1124) |
34 |
OB_003715 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
UBR2 |
Saccharomyces cerevisiae |
850711 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
26.23% |
38.5 |
30.5 |
divisions |
mean |
30 |
℃ |
matalpha |
Replicative life span on YEPD plates. 60 cells of each. |
Kruegel et al. |
2011 |
21931558 |
doi:10.1371/journal.pgen.1002253 |
Lifespan Observations Database (ID: 5230) |
35 |
OB_000108 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
increased |
25.27% |
34.2 |
27.3 |
divisions |
mean |
30 |
℃ |
matalpha |
Addition of 5 mM nicotinamide has no effect on replicative life span in BY4742 sir2 fob1 double mutant cells. Dietary restriction is still able to increase life span of sir2 fob1 double mutant cells treated with 5 mM nicotinamide. These data demonstrate that SIR2 and other nicotinamide-sensitive sirtuins are not required for life span extension from dietary restriction in the BY4742 strain background. |
Kaeberlein et al. |
2005 |
16311627 |
doi:10.1371/journal.pgen.0010069 |
Lifespan Observations Database (ID: 1119) |
36 |
OB_000525 |
Saccharomyces cerevisiae |
W303AR5 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
over-expression |
- |
unknown |
unknown |
|
|
|
increased |
25.22% |
28.8 |
23 |
|
mean |
30 |
℃ |
mata |
Deletion of SIR2 shortens life span. Overexpression of SIR2 increases life span. |
Kaeberlein et al. |
1999 |
10521401 |
|
Lifespan Observations Database (ID: 1787) |
37 |
OB_003958 |
Saccharomyces cerevisiae |
W303AR5 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
over-expression |
- |
unknown |
unknown |
|
|
|
increased |
25.22% |
28.8 |
23 |
divisions |
mean |
30 |
℃ |
mata |
Overexpression of SIR2 extended lifespan and deletion of SIR2 shortened life span. |
Kaeberlein et al. |
1999 |
10521401 |
|
Lifespan Observations Database (ID: 669) |
38 |
OB_004179 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
over-expression |
- |
unknown |
unknown |
|
|
|
increased |
24.00% |
|
27.8 |
|
mean |
30 |
℃ |
|
A strain overexpressing a single copy of SIR2 had a replicative life span that was significantly increased relative to wild type BY4742 cells.") |
Kaeberlein et al. |
2005 |
15722108 |
doi:10.1016/j.mad.2004.10.007 |
Lifespan Observations Database (ID: 869) |
39 |
OB_000159 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.5% glucose |
|
increased |
19.92% |
31.3 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1170) |
40 |
OB_000143 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.5% glucose |
|
increased |
17.62% |
30.7 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1156) |
41 |
OB_000154 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
increased |
15.33% |
30.1 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1166) |
42 |
OB_000152 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
11.11% |
29 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1164) |
43 |
OB_000162 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
6.51% |
27.8 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1173) |
44 |
OB_000157 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
6.13% |
27.7 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1169) |
45 |
OB_000524 |
Saccharomyces cerevisiae |
W303AR5 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HML |
Saccharomyces cerevisiae |
|
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
5.80% |
21.9 |
20.7 |
|
mean |
30 |
℃ |
mata |
Deletion of FOB1 increases life span and restores the short life span of a SIR2 deletion mutant back to wild type levels. |
Kaeberlein et al. |
1999 |
10521401 |
|
Lifespan Observations Database (ID: 1786) |
46 |
OB_000146 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
increased |
5.75% |
27.6 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1159) |
47 |
OB_000118 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
5.06% |
27 |
25.7 |
|
|
30 |
℃ |
matalpha |
Deletion of HXK2 significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from deletion of HXK2. Deletion of HXK2 is proposed as a genetic mimic of dietary restriction [ 11000115]. |
Kaeberlein et al. |
2006 |
16741098 |
doi:10.1126/science.1124608 |
Lifespan Observations Database (ID: 1128) |
48 |
OB_004197 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
none |
4.84% |
26 |
24.8 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of both FOB1 and SIR2 did not significantly influence life span, relative to wild type BY4742 mother cells. |
Kaeberlein et al. |
2004 |
15328540 |
doi:10.1371/journal.pbio.0020296 |
Lifespan Observations Database (ID: 885) |
49 |
OB_000142 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
none |
3.45% |
27 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1155) |
50 |
OB_004213 |
Saccharomyces cerevisiae |
PSY316AT |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
over-expression |
- |
unknown |
unknown |
|
|
|
none |
2.84% |
21.7 |
21.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Overexpression of SIR2 did not significantly change the life span of PSY316AT mother cells. |
Kaeberlein et al. |
2004 |
15328540 |
doi:10.1371/journal.pbio.0020296 |
Lifespan Observations Database (ID: 904) |
51 |
OB_000113 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
none |
2.83% |
25.4 |
24.7 |
|
|
30 |
℃ |
matalpha |
Dietary restriction at 0.5%, 0.05%, or 0.005% glucose significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from dietary restriction. |
Kaeberlein et al. |
2006 |
16741098 |
doi:10.1126/science.1124608 |
Lifespan Observations Database (ID: 1123) |
52 |
OB_000093 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
none |
2.45% |
25.1 |
24.5 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of TOR or SCH9 increase life span of sir2 fob1 double mutant cells. SIR2 and FOB1 are believed to act in a single genetic pathway to promote replicative life span by reducing the accumulation of extrachromosomal rDNA circles in the mother cell [ 10521401]. Since dietary restriction also increases the life span of sir2 fob1 double mutant cells [ 15328540], this supports the model that TOR1, SCH9, and dietary restriction act in a single pathway that is distinct from SIR2, FOB1, and extrachromosomal rDNA circles. |
Kaeberlein et al. |
2005 |
16293764 |
doi:10.1126/science.1115535 |
Lifespan Observations Database (ID: 1092) |
53 |
OB_000165 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
none |
2.30% |
26.7 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1176) |
54 |
OB_000149 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
none |
1.15% |
26.4 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1161) |
55 |
OB_000111 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
none |
1.10% |
27.6 |
27.3 |
divisions |
mean |
30 |
℃ |
matalpha |
Addition of 5 mM nicotinamide has no effect on replicative life span in BY4742 sir2 fob1 double mutant cells. Dietary restriction is still able to increase life span of sir2 fob1 double mutant cells treated with 5 mM nicotinamide. These data demonstrate that SIR2 and other nicotinamide-sensitive sirtuins are not required for life span extension from dietary restriction in the BY4742 strain background. |
Kaeberlein et al. |
2005 |
16311627 |
doi:10.1371/journal.pgen.0010069 |
Lifespan Observations Database (ID: 1121) |
56 |
OB_000112 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
none |
0.73% |
27.5 |
27.3 |
divisions |
mean |
30 |
℃ |
matalpha |
Addition of 5 mM nicotinamide has no effect on replicative life span in BY4742 sir2 fob1 double mutant cells. Dietary restriction is still able to increase life span of sir2 fob1 double mutant cells treated with 5 mM nicotinamide. These data demonstrate that SIR2 and other nicotinamide-sensitive sirtuins are not required for life span extension from dietary restriction in the BY4742 strain background. |
Kaeberlein et al. |
2005 |
16311627 |
doi:10.1371/journal.pgen.0010069 |
Lifespan Observations Database (ID: 1122) |
57 |
OB_000334 |
Saccharomyces cerevisiae |
W303AR5 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HML |
Saccharomyces cerevisiae |
|
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
loss of function |
R345A |
unknown |
unknown |
|
|
|
none |
0.00% |
22 |
22 |
divisions |
mean |
30 |
℃ |
mata |
Mutation of Sir2 asparagine 345 to alanine modestly decreased activity but did not shorten life span. |
Imai et al. |
2000 |
10693811 |
doi:10.1038/35001622 |
Lifespan Observations Database (ID: 160) |
58 |
OB_000164 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
none |
-2.30% |
25.5 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1175) |
59 |
OB_000045 |
Saccharomyces cerevisiae |
PSY316AT |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
over-expression |
- |
unknown |
unknown |
|
|
|
none |
-2.58% |
22.7 |
23.3 |
divisions |
mean |
30 |
℃ |
matalpha |
Integration of a second copy of SIR2 failed to significantly alter life span in the PSY316 strain background. This differs from the increased life span observed for SIR2-overexpression in wth W303 and BY4742 strain backgrounds. |
Kaeberlein et al. |
2005 |
15684413 |
doi:10.1074/jbc.M500655200 |
Lifespan Observations Database (ID: 1040) |
60 |
OB_000551 |
Saccharomyces cerevisiae |
PSY316 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-6.06% |
21.7 |
23.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Life-span extension by the cdc25-10 mutation requires the presence of Sir2p and Npt1p, an enzyme in a pathway of NAD synthesis. |
Lin et al. |
2000 |
11000115 |
|
Lifespan Observations Database (ID: 1810) |
61 |
OB_000527 |
Saccharomyces cerevisiae |
W303AR5 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
over-expression |
- |
unknown |
unknown |
|
|
|
decreased |
-7.39% |
21.3 |
23 |
|
mean |
30 |
℃ |
mata |
Deletion of SIR2 shortens life span. Overexpression of SIR2 increases life span. |
Kaeberlein et al. |
1999 |
10521401 |
|
Lifespan Observations Database (ID: 1789) |
62 |
OB_000552 |
Saccharomyces cerevisiae |
PSY316 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
CDC25 |
Saccharomyces cerevisiae |
851019 |
non-null recessive |
cdc25-10 |
unknown |
unknown |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-9.09% |
21 |
23.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Life-span extension by the cdc25-10 mutation requires the presence of Sir2p and Npt1p, an enzyme in a pathway of NAD synthesis. |
Lin et al. |
2000 |
11000115 |
|
Lifespan Observations Database (ID: 1811) |
63 |
OB_000156 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-13.79% |
22.5 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1168) |
64 |
OB_000880 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-14.29% |
6 |
7 |
days |
median |
30 |
℃ |
matalpha |
Deletion of sir2, hst1, hst2, hst3, hst4 or all 5 sirtuins at the same time had no effect on chronological life span and did not reduce life span extension from dietary restriction at 0.5% or 0.05% glucose. |
Murakami et al. |
2008 |
18314444 |
|
Lifespan Observations Database (ID: 2185) |
65 |
OB_003096 |
Saccharomyces cerevisiae |
YPK9 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Nonessential amino acids removed from media. |
|
decreased |
-16.03% |
11 |
13.1 |
divisions |
mean |
30 |
℃ |
mata |
Combining deletion of the histone deacetylase SIR2 with dietary restriction by removal of nonessential amino acids from the media reduces lifespan by 16.0%. Deletion of SIR2 partially prevented lifespan extension from amino acid restriction. |
Jiang et al. |
2002 |
12213553 |
|
Lifespan Observations Database (ID: 4476) |
66 |
OB_003712 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-17.38% |
25.2 |
30.5 |
divisions |
mean |
30 |
℃ |
matalpha |
Replicative life span on YEPD plates. 60 cells of each. |
Kruegel et al. |
2011 |
21931558 |
doi:10.1371/journal.pgen.1002253 |
Lifespan Observations Database (ID: 5228) |
67 |
OB_000519 |
Saccharomyces cerevisiae |
W303AR5D |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
heterozygous |
unknown |
unknown |
|
|
|
decreased |
-25.53% |
14 |
18.8 |
|
mean |
30 |
℃ |
diploid |
Homozygous deletion of SIR2 shortened life span to a greater extent than heterozygous deletion of SIR2 in diploid W303AR5D cells. |
Kaeberlein et al. |
1999 |
10521401 |
|
Lifespan Observations Database (ID: 1780) |
68 |
OB_003094 |
Saccharomyces cerevisiae |
YPK9 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Media glucose reduced from 2% to 0.1%. |
|
decreased |
-27.20% |
9.1 |
12.5 |
divisions |
mean |
30 |
℃ |
mata |
Combining deletion of the histone deacetylase SIR2 with dietary restriction by reducing media glucose from 2% to 0.1% reduces lifespan by 27.2%. Deletion of SIR2 did not prevent lifespan extension from glucose restriction. |
Jiang et al. |
2002 |
12213553 |
|
Lifespan Observations Database (ID: 4473) |
69 |
OB_000594 |
Saccharomyces cerevisiae |
YPK9 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-33.16% |
12.5 |
18.7 |
divisions |
mean |
30 |
℃ |
mata |
Deletion of SIR2 shortened life span in the YPK9 background and prevented life span extension from deletion of RPD3. No difference in the abundance of extrachromosomal rDNA circles was observed in sir2 deletion mutants relative to wild type in unsorted young cells in this strain background. |
Kim et al. |
1999 |
10512855 |
|
Lifespan Observations Database (ID: 1851) |
70 |
OB_000517 |
Saccharomyces cerevisiae |
W303AR5D |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
homozygous |
unknown |
unknown |
|
|
|
decreased |
-35.64% |
12.1 |
18.8 |
|
mean |
30 |
℃ |
diploid |
Homozygous deletion of SIR2 shortened life span to a greater extent than heterozygous deletion of SIR2 in diploid W303AR5D cells. |
Kaeberlein et al. |
1999 |
10521401 |
|
Lifespan Observations Database (ID: 1779) |
71 |
OB_000153 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-36.02% |
16.7 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1165) |
72 |
OB_000523 |
Saccharomyces cerevisiae |
W303AR5 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HML |
Saccharomyces cerevisiae |
|
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-37.20% |
13 |
20.7 |
|
mean |
30 |
℃ |
mata |
Deletion of FOB1 increases life span and restores the short life span of a SIR2 deletion mutant back to wild type levels. |
Kaeberlein et al. |
1999 |
10521401 |
|
Lifespan Observations Database (ID: 1785) |
73 |
OB_003095 |
Saccharomyces cerevisiae |
YPK9 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-37.40% |
8.2 |
13.1 |
divisions |
mean |
30 |
℃ |
mata |
Deletion of the histone deacetylase SIR2 reduces lifespan on 2% glucose media with standard amino acid content by 37.4%. |
Jiang et al. |
2002 |
12213553 |
|
Lifespan Observations Database (ID: 4475) |
74 |
OB_000568 |
Saccharomyces cerevisiae |
W303-1A |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SGS1 |
Saccharomyces cerevisiae |
855228 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
over-expression |
- |
unknown |
unknown |
|
|
|
decreased |
-37.56% |
12.8 |
20.5 |
divisions |
mean |
30 |
℃ |
mata |
Maximum life span of SGS1 deletion mutants can be extended by deletion of FOB1 or overexpression of SIR2. |
McVey et al. |
2001 |
11290710 |
|
Lifespan Observations Database (ID: 1828) |
75 |
OB_000593 |
Saccharomyces cerevisiae |
YPK9 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
RPD3 |
Saccharomyces cerevisiae |
855386 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-37.97% |
11.6 |
18.7 |
divisions |
mean |
30 |
℃ |
mata |
Deletion of SIR2 shortened life span in the YPK9 background and prevented life span extension from deletion of RPD3. No difference in the abundance of extrachromosomal rDNA circles was observed in sir2 deletion mutants relative to wild type in unsorted young cells in this strain background. |
Kim et al. |
1999 |
10512855 |
|
Lifespan Observations Database (ID: 1850) |
76 |
OB_000106 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
decreased |
-44.14% |
14.3 |
25.6 |
divisions |
mean |
30 |
℃ |
matalpha |
Addition of 5 mM nicotinamide shortens replicative life span in the BY4742 strain background to the same extent as deletion of SIR2. The combination of SIR2 deletion with 5 mM nicotinamide does not further shorten life span. This indicates that 5 mM nicotinamide is likely reducing life span by inhibition of SIR2. |
Kaeberlein et al. |
2005 |
16311627 |
doi:10.1371/journal.pgen.0010069 |
Lifespan Observations Database (ID: 1116) |
77 |
OB_000507 |
Saccharomyces cerevisiae |
W303AR5 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HML |
Saccharomyces cerevisiae |
|
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-44.39% |
11.9 |
21.4 |
|
mean |
30 |
℃ |
mata |
Deletion of SIR2 shortened life span of haploid mother cells. This reduction in life span extension was not suppressed by preventing mating type heterozygosity through deletion of the silent mating loci HML |
Kaeberlein et al. |
1999 |
10521401 |
|
Lifespan Observations Database (ID: 1768) |
78 |
OB_000454 |
Saccharomyces cerevisiae |
W303AR5 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-44.86% |
11.8 |
21.4 |
divisions |
mean |
30 |
℃ |
mata |
Deletion of SIR2 shortens life-span by approximately 50% in haploid cells. Homozygous deletion of SIR2 similarly shortens the life span of diploid cells and heterozygous deletion more modestly shortens life span. The shortened life span is likely caused by an increased rate of formation of extrachromosomal rDNA circles [ 10521401]. Single copy overexpression extends life-span by approximately 35% . |
Kaeberlein et al. |
1999 |
10521401 |
|
Lifespan Observations Database (ID: 171) |
79 |
OB_000508 |
Saccharomyces cerevisiae |
W303AR5 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-44.86% |
11.8 |
21.4 |
|
mean |
30 |
℃ |
mata |
Deletion of SIR2 shortened life span of haploid mother cells. This reduction in life span extension was not suppressed by preventing mating type heterozygosity through deletion of the silent mating loci HML |
Kaeberlein et al. |
1999 |
10521401 |
|
Lifespan Observations Database (ID: 1769) |
80 |
OB_000569 |
Saccharomyces cerevisiae |
W303-1A |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SGS1 |
Saccharomyces cerevisiae |
855228 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
over-expression |
- |
unknown |
unknown |
|
|
|
decreased |
-46.34% |
11 |
20.5 |
divisions |
mean |
30 |
℃ |
mata |
Maximum life span of SGS1 deletion mutants can be extended by deletion of FOB1 or overexpression of SIR2. |
McVey et al. |
2001 |
11290710 |
|
Lifespan Observations Database (ID: 1829) |
81 |
OB_003093 |
Saccharomyces cerevisiae |
YPK9 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-46.40% |
6.7 |
12.5 |
divisions |
mean |
30 |
℃ |
mata |
Deletion of the histone deacetylase SIR2 reduces lifespan on 2% glucose media by 46.4%. |
Jiang et al. |
2002 |
12213553 |
|
Lifespan Observations Database (ID: 4472) |
82 |
OB_004127 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-47.00% |
|
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
The sir2 deletion from the MATalpha haploid yeast orf deletion collection had a shortened replicative life span relative to wild type BY4742 cells. |
Kaeberlein et al. |
2005 |
15722108 |
doi:10.1016/j.mad.2004.10.007 |
Lifespan Observations Database (ID: 821) |
83 |
OB_000107 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-47.27% |
13.5 |
25.6 |
divisions |
mean |
30 |
℃ |
matalpha |
Addition of 5 mM nicotinamide shortens replicative life span in the BY4742 strain background to the same extent as deletion of SIR2. The combination of SIR2 deletion with 5 mM nicotinamide does not further shorten life span. This indicates that 5 mM nicotinamide is likely reducing life span by inhibition of SIR2. |
Kaeberlein et al. |
2005 |
16311627 |
doi:10.1371/journal.pgen.0010069 |
Lifespan Observations Database (ID: 1118) |
84 |
OB_000125 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-47.35% |
13.9 |
26.4 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of HST1, HST2, or HST4 had no effect on replicative life span of BY4742 mother cells. Deletion of either SIR2 or HST3 shortened life span. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1137) |
85 |
OB_004194 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-47.57% |
14 |
26.7 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of both SIR2 significantly decreased life span in the BY4742 background. |
Kaeberlein et al. |
2004 |
15328540 |
doi:10.1371/journal.pbio.0020296 |
Lifespan Observations Database (ID: 882) |
86 |
OB_000128 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-48.66% |
13.4 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1142) |
87 |
OB_000332 |
Saccharomyces cerevisiae |
W303AR5 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HML |
Saccharomyces cerevisiae |
|
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-50.00% |
11 |
22 |
|
|
30 |
℃ |
mata |
Deletion of SIR2 shortened life span. The HML deletion in this haploid strain prevents co-expression of both mating types. |
Imai et al. |
2000 |
10693811 |
doi:10.1038/35001622 |
Lifespan Observations Database (ID: 159) |
88 |
OB_000604 |
Saccharomyces cerevisiae |
W303-1A |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HML |
Saccharomyces cerevisiae |
|
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
loss of function |
G270A |
unknown |
unknown |
|
|
|
decreased |
-50.00% |
11 |
22 |
divisions |
mean |
30 |
℃ |
mata |
Mutation of Sir2 glycine 240 to alanine decreased activity and reduced life span. |
Imai et al. |
2000 |
10693811 |
doi:10.1038/35001622 |
Lifespan Observations Database (ID: 1867) |
89 |
OB_000549 |
Saccharomyces cerevisiae |
PSY316 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-51.95% |
11.1 |
23.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Life-span extension by the cdc25-10 mutation requires the presence of Sir2p and Npt1p, an enzyme in a pathway of NAD synthesis. |
Lin et al. |
2000 |
11000115 |
|
Lifespan Observations Database (ID: 1809) |
90 |
OB_000300 |
Saccharomyces cerevisiae |
W303AR5 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-52.17% |
11 |
23 |
divisions |
mean |
30 |
℃ |
mata |
Overexpression of SIR2 extended lifespan and deletion of SIR2 shortened life span. |
Kaeberlein et al. |
1999 |
10521401 |
|
Lifespan Observations Database (ID: 1302) |
91 |
OB_000526 |
Saccharomyces cerevisiae |
W303AR5 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-52.17% |
11 |
23 |
|
mean |
30 |
℃ |
mata |
Deletion of SIR2 shortens life span. Overexpression of SIR2 increases life span. |
Kaeberlein et al. |
1999 |
10521401 |
|
Lifespan Observations Database (ID: 1788) |
92 |
OB_004195 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HXK2 |
Saccharomyces cerevisiae |
852639 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-53.56% |
12.4 |
26.7 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of both HXK2 and SIR2 significantly decreased life span in the BY4742 background to the same extent as deletion of SIR2 alone. |
Kaeberlein et al. |
2004 |
15328540 |
doi:10.1371/journal.pbio.0020296 |
Lifespan Observations Database (ID: 883) |
93 |
OB_000129 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
decreased |
-54.02% |
12 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1143) |
94 |
OB_000548 |
Saccharomyces cerevisiae |
PSY316 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
CDC25 |
Saccharomyces cerevisiae |
851019 |
non-null recessive |
cdc25-10 |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-54.98% |
10.4 |
23.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Life-span extension by the cdc25-10 mutation requires the presence of Sir2p and Npt1p, an enzyme in a pathway of NAD synthesis. |
Lin et al. |
2000 |
11000115 |
|
Lifespan Observations Database (ID: 1808) |
95 |
OB_004196 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
GPA2 |
Saccharomyces cerevisiae |
856741 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-56.18% |
11.7 |
26.7 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of both GPA2 and SIR2 significantly decreased life span in the BY4742 background to the same extent as deletion of SIR2 alone. |
Kaeberlein et al. |
2004 |
15328540 |
doi:10.1371/journal.pbio.0020296 |
Lifespan Observations Database (ID: 884) |
96 |
OB_000166 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-73.56% |
6.9 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1177) |
97 |
OB_000167 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
decreased |
-75.10% |
6.5 |
26.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Tsuchiya et al. |
2006 |
17129213 |
doi:10.1111/j.1474-9726.2006.00240.x |
Lifespan Observations Database (ID: 1178) |
98 |
OB_002880 |
Saccharomyces cerevisiae |
BY4741 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
over-expression |
2X |
unknown |
unknown |
|
|
|
none |
|
|
|
days |
max |
30 |
℃ |
mata |
Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins. |
Smith et al. |
2007 |
17711561 |
doi:10.1111/j.1474-9726.2007.00326.x |
Lifespan Observations Database (ID: 4168) |
99 |
OB_005919 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
Deletion |
- |
wildtype |
yes |
|
|
|
increased |
|
|
|
|
unknown |
|
|
|
Mean chronological lifespan increased in the a strain |
Matecic et al. |
2010 |
20421943 |
doi:10.1371/journal.pgen.1000921 |
GenAge |