Gene: Neil1 - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
Neil1 |
NCBI Gene ID |
: |
72774 |
Species |
: |
Mus musculus |
Gene Synonyms |
: |
DNA glycosylase/AP lyase Neil1 | DNA-(apurinic or apyrimidinic site) lyase Neil1 | endonuclease 8-like 1 | endonuclease VIII | endonuclease VIII-like 1 | NEH1 | nei endonuclease VIII-like 1 (E. coli) | nei homolog 1 | nei-like protein 1 | Nei1 | Neil1
Source: GPSDB |
Gene Homologs |
: |
NEIL1 (Bos taurus) | NEIL1 (Canis lupus familiaris) | neil1 (Danio rerio) | NEIL1 (Gallus gallus) | NEIL1 (Homo sapiens) | NEIL1 (Macaca mulatta) | Neil1 (Mus musculus) | NEIL1 (Pan troglodytes) | Neil1 (Rattus norvegicus) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
2 |
|
|
|
Ageing Factor Stable ID |
: |
AF_008480 |
Download |
: |
XML |
Protein Information
Protein Name |
Species |
UniProt Accession Number |
UniProt Entry Name |
Protein Function |
Sequence |
Endonuclease 8-like 1 |
Mus musculus |
Q8K4Q6 (UniProtKB/Swiss-Prot) |
NEIL1_MOUSE (UniProtKB/Swiss-Prot) |
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. |
View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005612 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Neil1 |
72774 |
|
|
Knockout mice develop severe obesity, dyslipidemia, fatty liver disease, increased levels of DNA damage in the mtDNA, and have a tendency to develop hyperinsulinemia. |
16446448 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_005613 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Neil1 |
Mus musculus |
72774 |
Knockout |
- |
wildtype |
yes |
|
|
|
decreased |
|
|
|
|
unknown |
|
|
|
Knockout mice develop severe obesity, dyslipidemia, fatty liver disease, increased levels of DNA damage in the mtDNA, and have a tendency to develop hyperinsulinemia. |
Vartanian et al. |
2006 |
16446448 |
doi:10.1073/pnas.0507444103 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_009128 |
|
1 |
The HomoloGene homology group 11616 contains 1 gene with experimental evidence for ageing relevance (Neil1 - Mus musculus) and 8 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 11616 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Vartanian V, Lowell B, Minko IG, Wood TG, Ceci JD, George S, Ballinger SW, Corless CL, McCullough AK, Lloyd RS:
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
Proc Natl Acad Sci USA. 2006; 103: 1864-9.
PubMed (ID: 16446448), PubMed Central (ID: PMC1413631), doi:10.1073/pnas.0507444103
MeSH Terms: DNA Glycosylases/deficiency; DNA Glycosylases/metabolism; Gene Deletion; Metabolic Syndrome X/genetics; Metabolic Syndrome X/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources