Gene: PRKDC - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | PRKDC | ||||||||||||||||
NCBI Gene ID | : | 5591 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | DNA-DEPENDENT PROTEIN KINASE | DNA-dependent protein kinase catalytic subunit | DNA-DEPENDENT PROTEIN KINASE, CATALYTIC SUBUNIT | DNA-PK catalytic subunit | DNA-PKcs | DNAPK | DNPK1 | hyper-radiosensitivity of murine scid mutation, complementing 1 | HYPERRADIOSENSITIVITY COMPLEMENTING 1, MOUSE, HOMOLOG OF | HYRC | HYRC1 | p350 | p460 | PRKDC | protein kinase, DNA-activated, catalytic polypeptide | PROTEIN KINASE, DNA-ACTIVATED, CATALYTIC SUBUNIT | XRCC7 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP003967 (Anopheles gambiae) | PRKDC (Bos taurus) | PRKDC (Canis lupus familiaris) | PRKDC (Gallus gallus) | PRKDC (Homo sapiens) | PRKDC (Macaca mulatta) | Prkdc (Mus musculus) | PRKDC (Pan troglodytes) | Prkdc (Rattus norvegicus) | wu:fa96e12 (Danio rerio) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_008555 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
DNA-dependent protein kinase catalytic subunit | Homo sapiens | P78527 (UniProtKB/Swiss-Prot) | PRKDC_HUMAN (UniProtKB/Swiss-Prot) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_009736 | Homo sapiens |
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PRKDC is involved in DNA repair and may modulate transcription [0554]. Evidence also suggests PRKDC may be involved in telomere biology [0557]. Because PRKDC has been associated with many pathways with genes likely to be involved in human ageing, such as WRN [0558], it is possible that PRKDC itself is involved in human ageing, though further research is necessary to investigate this hypothesis. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008236 | 1 | The HomoloGene homology group 5037 contains 1 gene with experimental evidence for ageing relevance (PRKDC - Homo sapiens) and 9 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 5037 |
Sequences
PRKDC_HUMAN | P78527 | DNA-dependent protein kinase catalytic subunit (Homo sapiens) from UniProtKB/Swiss-Prot Length: 4128 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 1930 1940 1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 2050 2060 2070 2080 2090 2100 2110 2120 2130 2140 2150 2160 2170 2180 2190 2200 2210 2220 2230 2240 2250 2260 2270 2280 2290 2300 2310 2320 2330 2340 2350 2360 2370 2380 2390 2400 2410 2420 2430 2440 2450 2460 2470 2480 2490 2500 2510 2520 2530 2540 2550 2560 2570 2580 2590 2600 2610 2620 2630 2640 2650 2660 2670 2680 2690 2700 2710 2720 2730 2740 2750 2760 2770 2780 2790 2800 2810 2820 2830 2840 2850 2860 2870 2880 2890 2900 2910 2920 2930 2940 2950 2960 2970 2980 2990 3000 3010 3020 3030 3040 3050 3060 3070 3080 3090 3100 3110 3120 3130 3140 3150 3160 3170 3180 3190 3200 3210 3220 3230 3240 3250 3260 3270 3280 3290 3300 3310 3320 3330 3340 3350 3360 3370 3380 3390 3400 3410 3420 3430 3440 3450 3460 3470 3480 3490 3500 3510 3520 3530 3540 3550 3560 3570 3580 3590 3600 3610 3620 3630 3640 3650 3660 3670 3680 3690 3700 3710 3720 3730 3740 3750 3760 3770 3780 3790 3800 3810 3820 3830 3840 3850 3860 3870 3880 3890 3900 3910 3920 3930 3940 3950 3960 3970 3980 3990 4000 4010 4020 4030 4040 4050 4060 4070 4080 4090 4100 4110 4120 PRKDC_HUMAN 1 MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFSRDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRAAKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGLLGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEEDPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELSIAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCISTVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQMMDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGVWMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRLPLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQYKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNLSSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFREMKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQLYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDPVDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASLAFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEKKHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPGNRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLLLAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGNRTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPASIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPDAQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCLPSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFYSLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLATTILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLADTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYVDCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLESVYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNESTFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCYDAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFENLIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEMSQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTALVKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPYAKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLMKHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIVMANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEESLCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEVVLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVEFVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLIIRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHPLSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQQHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDFGKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSELKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEMDKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGCLASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLRGIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLDCYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQSLLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVLLHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM 4128
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Labhart P:
DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I.
Proc Natl Acad Sci USA. 1995; 92: 2934-8.
PubMed (ID: 7708751), PubMed Central (ID: PMC42333)
MeSH Terms: Gene Expression; Pol1 Transcription Initiation Complex Proteins; Promoter Regions, Genetic; Protein-Serine-Threonine Kinases/metabolism; RNA Polymerase I/metabolism; Transcription Factors/metabolism; Transcription, Genetic - Li B, Comai L:
Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein.
Nucleic Acids Res. 2002; 30: 3653-61.
PubMed (ID: 12202749), PubMed Central (ID: PMC137412)
MeSH Terms: Antigens, Nuclear; DNA Helicases; Protein-Serine-Threonine Kinases/metabolism - Espejel S, Franco S, Sgura A, Gae D, Bailey SM, Taccioli GE, Blasco MA:
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.
EMBO J. 2002; 21: 6275-87.
PubMed (ID: 12426399), PubMed Central (ID: PMC137185)
MeSH Terms: DNA-Binding Proteins; Protein Interaction Mapping; Protein-Serine-Threonine Kinases/physiology; RNA/physiology; Telomerase/physiology; Telomere/ultrastructure - Yang J, Yu Y, Hamrick HE, Duerksen-Hughes PJ:
ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses.
Carcinogenesis. 2003; 24: 1571-80.
PubMed (ID: 12919958), doi:10.1093/carcin/bgg137
MeSH Terms: Cell Cycle Proteins/physiology; DNA-Binding Proteins; Mutagens/pharmacology; Protein-Serine-Threonine Kinases/physiology; Signal Transduction/physiology - Stiff T, O'Driscoll M, Rief N, Iwabuchi K, Löbrich M, Jeggo PA:
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.
Cancer Res. 2004; 64: 2390-6.
PubMed (ID: 15059890)
MeSH Terms: DNA-Binding Proteins; Histones/metabolism; Protein-Serine-Threonine Kinases/metabolism - Espejel S, Klatt P, Ménissier-de Murcia J, Martín-Caballero J, Flores JM, Taccioli G, de Murcia G, Blasco MA:
Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs.
J Cell Biol. 2004; 167: 627-38.
PubMed (ID: 15545322), PubMed Central (ID: PMC2172587), doi:10.1083/jcb.200407178
MeSH Terms: Aging, Premature/genetics; Antigens, Nuclear/genetics; Cell Transformation, Neoplastic/genetics; DNA Repair/genetics; DNA-Binding Proteins/genetics; Poly(ADP-ribose) Polymerases/genetics; Protein-Serine-Threonine Kinases/genetics; Telomerase/physiology - Lan L, Nakajima S, Komatsu K, Nussenzweig A, Shimamoto A, Oshima J, Yasui A:
Accumulation of Werner protein at DNA double-strand breaks in human cells.
J Cell Sci. 2005; 118: 4153-62.
PubMed (ID: 16141234), doi:10.1242/jcs.02544
MeSH Terms: DNA Damage; DNA Helicases/metabolism; DNA/metabolism - Wong KK, Maser RS, Sahin E, Bailey ST, Xia H, Ji H, McNamara K, Naylor M, Bronson RT, Ghosh S, Welsh R, DePinho RA:
Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres.
Oncogene. 2007; 26: 2815-21.
PubMed (ID: 17072335), doi:10.1038/sj.onc.1210099
MeSH Terms: DNA-Activated Protein Kinase/genetics; DNA-Binding Proteins/genetics; Longevity/genetics; Nuclear Proteins/genetics; Stress, Physiological/genetics; Stress, Physiological/mortality; Telomere/metabolism - Kuhn A, Gottlieb TM, Jackson SP, Grummt I:
DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I.
Genes Dev. 1995; 9: 193-203.
PubMed (ID: 7851793)
MeSH Terms: DNA-Binding Proteins; Protein-Serine-Threonine Kinases/metabolism; RNA Polymerase I/metabolism; Transcription, Genetic/drug effects - Araki R, Fujimori A, Hamatani K, Mita K, Saito T, Mori M, Fukumura R, Morimyo M, Muto M, Itoh M, Tatsumi K, Abe M:
Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice.
Proc Natl Acad Sci USA. 1997; 94: 2438-43.
PubMed (ID: 9122213), PubMed Central (ID: PMC20106)
MeSH Terms: DNA-Binding Proteins; Mice, SCID/genetics; Point Mutation; Protein-Serine-Threonine Kinases/genetics; Tyrosine - Salminen A, Helenius M, Lahtinen T, Korhonen P, Tapiola T, Soininen H, Solovyan V:
Down-regulation of Ku autoantigen, DNA-dependent protein kinase, and poly(ADP-ribose) polymerase during cellular senescence.
Biochem Biophys Res Commun. 1997; 238: 712-6.
PubMed (ID: 9325154), doi:10.1006/bbrc.1997.7371
MeSH Terms: Antigens, Nuclear; Autoantigens/metabolism; DNA Helicases; DNA-Binding Proteins/metabolism; Down-Regulation/physiology; Nuclear Proteins/metabolism; Poly(ADP-ribose) Polymerases/metabolism; Protein-Serine-Threonine Kinases/metabolism - Woo RA, McLure KG, Lees-Miller SP, Rancourt DE, Lee PW:
DNA-dependent protein kinase acts upstream of p53 in response to DNA damage.
Nature. 1998; 394: 700-4.
PubMed (ID: 9716137), doi:10.1038/29343
MeSH Terms: DNA Damage; DNA-Binding Proteins; Protein-Serine-Threonine Kinases/metabolism; Tumor Suppressor Protein p53/metabolism - Jimenez GS, Bryntesson F, Torres-Arzayus MI, Priestley A, Beeche M, Saito S, Sakaguchi K, Appella E, Jeggo PA, Taccioli GE, Wahl GM, Hubank M:
DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage.
Nature. 1999; 400: 81-3.
PubMed (ID: 10403253), doi:10.1038/21913
MeSH Terms: DNA Damage; DNA-Binding Proteins; Protein-Serine-Threonine Kinases/metabolism; Tumor Suppressor Protein p53/metabolism - Schild-Poulter C, Pope L, Giffin W, Kochan JC, Ngsee JK, Traykova-Andonova M, Haché RJ:
The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase.
J Biol Chem. 2001; 276: 16848-56.
PubMed (ID: 11279128), doi:10.1074/jbc.M100768200
MeSH Terms: Antigens, Nuclear; DNA Helicases; DNA-Binding Proteins/metabolism; Gene Expression Regulation; Homeodomain Proteins/metabolism; Nuclear Proteins/metabolism; Protein-Serine-Threonine Kinases/metabolism; Saccharomyces cerevisiae Proteins; Transcription, Genetic - Bailey SM, Cornforth MN, Kurimasa A, Chen DJ, Goodwin EH:
Strand-specific postreplicative processing of mammalian telomeres.
Science. 2001; 293: 2462-5.
PubMed (ID: 11577237), doi:10.1126/science.1062560
MeSH Terms: DNA Replication; DNA-Binding Proteins/metabolism; Telomere/metabolism - Karmakar P, Piotrowski J, Brosh RM, Sommers JA, Miller SP, Cheng WH, Snowden CM, Ramsden DA, Bohr VA:
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation.
J Biol Chem. 2002; 277: 18291-302.
PubMed (ID: 11889123), doi:10.1074/jbc.M111523200
MeSH Terms: DNA Helicases/metabolism; DNA-Binding Proteins; Protein-Serine-Threonine Kinases/metabolism; Werner Syndrome/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot