Gene: TFDP1 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | TFDP1 | ||||||||||||||||
NCBI Gene ID | : | 7027 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | Dp-1 | DP1 | DRTF1 | DRTF1-polypeptide 1 | E2F DIMERIZATION PARTNER 1 | E2F dimerization partner 1 | E2F-related transcription factor | RP11-230F18.1 | TFDP1 | transcription factor Dp-1 | TRANSCRIPTION FACTOR DP1 | TRANSCRIPTION FACTOR, SEQUENCE-SPECIFIC, DRTF1 Source: GPSDB |
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Gene Homologs | : | TFDP1 (Bos taurus) | TFDP1 (Canis lupus familiaris) | TFDP1 (Gallus gallus) | TFDP1 (Homo sapiens) | TFDP1 (Macaca mulatta) | Tfdp1 (Mus musculus) | tfdp1a (Danio rerio) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_008587 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Transcription factor Dp-1 | Homo sapiens | Q14186 (UniProtKB/Swiss-Prot) | TFDP1_HUMAN (UniProtKB/Swiss-Prot) | Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F-1/DP complex appears to mediate both cell proliferation and apoptosis. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_009792 | Homo sapiens |
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TFDP1 is a transcription factor that may play a role in cell cycle regulation and apoptosis [0878]. Despite its association with cellular senescence [1569], TFDP1 has not been directly linked to organismal ageing. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | ||||||||||||||||||||||||
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1 | OB_008164 |
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1 | The HomoloGene homology group 38276 contains 1 gene with experimental evidence for ageing relevance (TFDP1 - Homo sapiens) and 6 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 38276 |
Sequences
TFDP1_HUMAN | Q14186 | Transcription factor Dp-1 (Homo sapiens) from UniProtKB/Swiss-Prot Length: 410 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 TFDP1_HUMAN 1 MAKDAGLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNPLGKQLLPKTFGQSNVNIAQQVVIGTPQRPAASNTLVVGSPHTPSTHFASQNQPSDSSPWSAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRHAEQQASRPPPPNSVIHLPFIIVNTSKKTVIDCSISNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKMARSLVPKALEPYVTEMAQGTVGGVFITTAGSTSNGTRFSASDLTNGADGMLATSSNGSQYSGSRVETPVSYVGEDDEEDDDFNENDEDD 410
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- La Thangue NB, Thimmappaya B, Rigby PW:
The embryonal carcinoma stem cell Ela-like activity involves a differentiation-regulated transcription factor.
Nucleic Acids Res. 1990; 18: 2929-38.
PubMed (ID: 2140887), PubMed Central (ID: PMC330821)
MeSH Terms: Cell Differentiation; DNA-Binding Proteins/metabolism; Oncogene Proteins, Viral/metabolism; Promoter Regions, Genetic; Transcription Factors/metabolism - Bandara LR, La Thangue NB:
Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor.
Nature. 1991; 351: 494-7.
PubMed (ID: 1710781), doi:10.1038/351494a0
MeSH Terms: Carrier Proteins; Cell Cycle Proteins; DNA-Binding Proteins; Oncogene Proteins, Viral/pharmacology; Retinoblastoma Protein/metabolism - Zastrow MS, Vlcek S, Wilson KL:
Proteins that bind A-type lamins: integrating isolated clues.
J Cell Sci. 2004; 117: 979-87.
PubMed (ID: 14996929), doi:10.1242/jcs.01102
MeSH Terms: Carrier Proteins/metabolism; Lamin Type A/metabolism - Maehara K, Yamakoshi K, Ohtani N, Kubo Y, Takahashi A, Arase S, Jones N, Hara E:
Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53.
J Cell Biol. 2005; 168: 553-60.
PubMed (ID: 15716376), PubMed Central (ID: PMC2171766), doi:10.1083/jcb.200411093
MeSH Terms: Cell Aging/physiology; Cell Cycle Proteins/metabolism; DNA-Binding Proteins/metabolism; Retinoblastoma Protein/metabolism; Transcription Factors/metabolism; Tumor Suppressor Protein p53/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot