1 |
OB_000089 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
66.53% |
40.3 |
24.2 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of TOR1 increases life span additively with deletion of FOB1. These data support the model that TOR1 and FOB1 act in different pathways to promote longevity. |
Kaeberlein et al. |
2005 |
16293764 |
doi:10.1126/science.1115535 |
Lifespan Observations Database (ID: 1089) |
2 |
OB_000292 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
56.41% |
36.6 |
23.4 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of GCN4 prevents maximal life span extension from deletion of TOR1, deletion of SCH9, or dietary restriction. From Supplemental Figure 6. |
Steffen et al. |
2008 |
18423200 |
doi:10.1016/j.cell.2008.02.037 |
Lifespan Observations Database (ID: 1296) |
3 |
OB_000291 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
GCN4 |
Saccharomyces cerevisiae |
856709 |
deletion / null |
- |
unknown |
unknown |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
48.72% |
34.8 |
23.4 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of GCN4 prevents maximal life span extension from deletion of TOR1, deletion of SCH9, or dietary restriction. From Supplemental Figure 6. |
Steffen et al. |
2008 |
18423200 |
doi:10.1016/j.cell.2008.02.037 |
Lifespan Observations Database (ID: 1295) |
4 |
OB_000094 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
33.47% |
32.7 |
24.5 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of TOR or SCH9 increase life span of sir2 fob1 double mutant cells. SIR2 and FOB1 are believed to act in a single genetic pathway to promote replicative life span by reducing the accumulation of extrachromosomal rDNA circles in the mother cell [ 10521401]. Since dietary restriction also increases the life span of sir2 fob1 double mutant cells [ 15328540], this supports the model that TOR1, SCH9, and dietary restriction act in a single pathway that is distinct from SIR2, FOB1, and extrachromosomal rDNA circles. |
Kaeberlein et al. |
2005 |
16293764 |
doi:10.1126/science.1115535 |
Lifespan Observations Database (ID: 1093) |
5 |
OB_006078 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
Deletion |
- |
wildtype |
yes |
|
|
|
increased |
30.00% |
|
|
|
unknown |
|
|
|
Replicative lifespan increased by 30% in the alpha strain and 20% in a strain |
Managbanag et al. |
2008 |
19030232 |
doi:10.1371/journal.pone.0003802 |
GenAge |
6 |
OB_000080 |
Saccharomyces cerevisiae |
BY4741 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
25.30% |
31.7 |
25.3 |
divisions |
mean |
30 |
℃ |
mata |
Deletion of TOR1 significantly increased replicative life span of BY4741 cells. |
Kaeberlein et al. |
2005 |
16293764 |
doi:10.1126/science.1115535 |
Lifespan Observations Database (ID: 1079) |
7 |
OB_000064 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
23.00% |
|
|
divisions |
mean |
30 |
℃ |
matalpha |
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Kaeberlein et al. |
2005 |
16293764 |
doi:10.1126/science.1115535 |
Lifespan Observations Database (ID: 1064) |
8 |
OB_000088 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
22.31% |
29.6 |
24.2 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of TOR1 increases life span additively with deletion of FOB1. These data support the model that TOR1 and FOB1 act in different pathways to promote longevity. |
Kaeberlein et al. |
2005 |
16293764 |
doi:10.1126/science.1115535 |
Lifespan Observations Database (ID: 1088) |
9 |
OB_000066 |
Saccharomyces cerevisiae |
BY4741 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
22.00% |
|
|
divisions |
mean |
30 |
℃ |
mata |
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Kaeberlein et al. |
2005 |
16293764 |
doi:10.1126/science.1115535 |
Lifespan Observations Database (ID: 1066) |
10 |
OB_000211 |
Saccharomyces cerevisiae |
BY4741 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
21.60% |
|
|
divisions |
mean |
30 |
℃ |
mata |
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Smith et al. |
2008 |
18340043 |
doi:10.1101/gr.074724.107 |
Lifespan Observations Database (ID: 1217) |
11 |
OB_000084 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
21.28% |
28.5 |
23.5 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of TOR1 significantly increased replicative life span of BY4742 cells but does not further increase life span when combined with dietary restriction (0.05% glucose). These data support the model that TOR1 and dietary restriction act in the same pathway to promote longevity. |
Kaeberlein et al. |
2005 |
16293764 |
doi:10.1126/science.1115535 |
Lifespan Observations Database (ID: 1082) |
12 |
OB_000065 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
21.00% |
|
|
divisions |
mean |
30 |
℃ |
matalpha |
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Kaeberlein et al. |
2005 |
16293764 |
doi:10.1126/science.1115535 |
Lifespan Observations Database (ID: 1065) |
13 |
OB_000085 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
increased |
20.43% |
28.3 |
23.5 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of TOR1 significantly increased replicative life span of BY4742 cells but does not further increase life span when combined with dietary restriction (0.05% glucose). These data support the model that TOR1 and dietary restriction act in the same pathway to promote longevity. |
Kaeberlein et al. |
2005 |
16293764 |
doi:10.1126/science.1115535 |
Lifespan Observations Database (ID: 1083) |
14 |
OB_000179 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
20.30% |
|
|
divisions |
mean |
30 |
℃ |
matalpha |
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Smith et al. |
2008 |
18340043 |
doi:10.1101/gr.074724.107 |
Lifespan Observations Database (ID: 1189) |
15 |
OB_006075 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
Deletion |
- |
wildtype |
yes |
|
|
|
increased |
20.00% |
|
|
|
maximum |
|
|
|
Deletion increased mean and maximum lifespan by 20%. |
Kaeberlein et al. |
2005 |
16293764 |
doi:10.1126/science.1115535 |
GenAge |
16 |
OB_000096 |
Saccharomyces cerevisiae |
PSY316 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
19.25% |
25.4 |
21.3 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of TOR significantly increases the replicative life span of PSY316 mother cells. |
Kaeberlein et al. |
2005 |
16293764 |
doi:10.1126/science.1115535 |
Lifespan Observations Database (ID: 1095) |
17 |
OB_003702 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
RPN4 |
Saccharomyces cerevisiae |
851542 |
deletion / null |
- |
unknown |
unknown |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-41.87% |
16.8 |
28.9 |
divisions |
mean |
30 |
℃ |
matalpha |
Replicative life span on YEPD plates. 100 cells of rpn4 tor1, 80 cells of WT |
Kruegel et al. |
2011 |
21931558 |
doi:10.1371/journal.pgen.1002253 |
Lifespan Observations Database (ID: 5218) |
18 |
OB_003701 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
|
|
|
divisions |
mean |
30 |
℃ |
matalpha |
Replicative life span on YEPD plates. 100 cells of tor1, 80 cells of WT. |
Kruegel et al. |
2011 |
21931558 |
doi:10.1371/journal.pgen.1002253 |
Lifespan Observations Database (ID: 5217) |
19 |
OB_006077 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
Deletion |
- |
wildtype |
yes |
|
|
|
increased |
|
|
|
|
unknown |
|
|
|
Deletion of TOR1 substantially extended chronological life span, increasing median survival almost 3-fold (wild-type 4.5 days, tor1 null 12 days). By 21 days in culture, the vast majority of wild-type cells had died (>99.9%), whereas many tor1 null cells remained viable. Deletion of TOR1 also extended the chronological life span of the relatively short-lived strain BY4742, one of the two haploid genetic backgrounds of the widely used Yeast Knockout Collection available from Open Biosystems. Deletion of TOR1 fails to extendLS in Petite strains that are unable to respire |
Bonawitz et al. |
2007 |
17403371 |
doi:10.1016/j.cmet.2007.02.009 |
GenAge |
20 |
OB_006079 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
Deletion |
- |
wildtype |
yes |
|
|
|
increased |
|
|
|
|
unknown |
|
|
|
Mean chronological lifespan strongly increased in the a strain |
Matecic et al. |
2010 |
20421943 |
doi:10.1371/journal.pgen.1000921 |
GenAge |