1 |
OB_004299 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation |
|
increased |
59.01% |
35.3 |
22.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 failed to prevent life span extension from dietary restriction by bacterial deprivation. These data support the model that dietary restriction increases life span by a mechanism that does not require HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 993) |
2 |
OB_000027 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation |
|
increased |
51.60% |
33.2 |
21.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Dietary restriction by bacterial deprivation significantly increased the life span of vhl-1(ok161); hif-1(ia04) double mutant animals. These data support the model that dietary restriction acts in a longevity pathway parallel to VHL-1/HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1024) |
3 |
OB_000028 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation |
|
increased |
49.38% |
36 |
24.1 |
days |
mean |
20 |
℃ |
hermaphrodite |
Dietary restriction by bacterial deprivation significantly increased the life span of vhl-1(ok161); hif-1(ia04) double mutant animals. These data support the model that dietary restriction acts in a longevity pathway parallel to VHL-1/HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1025) |
4 |
OB_004298 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation |
|
increased |
46.06% |
35.2 |
24.1 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 failed to prevent life span extension from dietary restriction by bacterial deprivation. These data support the model that dietary restriction increases life span by a mechanism that does not require HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 992) |
5 |
OB_004302 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
unknown |
unknown |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
|
|
|
increased |
31.80% |
28.6 |
21.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 failed to prevent life span extension from RNAi knock-down of daf-2. These data support the model that reduced insulin-like signaling increases life span by a mechanism that does not require HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 996) |
6 |
OB_000029 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation |
|
increased |
29.95% |
28.2 |
21.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of daf-2 significantly increased the life span of vhl-1(ok161); hif-1(ia04) double mutant animals. These data support the model that insulin-like signaling acts in a longevity pathway parallel to VHL-1/HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1026) |
7 |
OB_004300 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation |
|
increased |
24.57% |
28.9 |
23.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 failed to prevent life span extension from dietary restriction by bacterial deprivation. These data support the model that dietary restriction increases life span by a mechanism that does not require HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 994) |
8 |
OB_004280 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
eat-2 |
Caenorhabditis elegans |
175072 |
loss of function |
ad465 |
unknown |
unknown |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
21.74% |
22.4 |
18.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of hif-1 failed to prevent life span extension from the eat-2(ad465) mutation. Eat-2 mutation is a genetic model of dietary restriction, since these animals eat less food due to a defect in pumping. These data support the model that life span extension from dietary restriction is independent of HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 976) |
9 |
OB_004279 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
eat-2 |
Caenorhabditis elegans |
175072 |
loss of function |
ad465 |
unknown |
unknown |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
20.38% |
25.4 |
21.1 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of hif-1 failed to prevent life span extension from the eat-2(ad465) mutation. Eat-2 mutation is a genetic model of dietary restriction, since these animals eat less food due to a defect in pumping. These data support the model that life span extension from dietary restriction is independent of HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 975) |
10 |
OB_004301 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation |
|
increased |
20.09% |
26.3 |
21.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 failed to prevent life span extension from dietary restriction by bacterial deprivation. These data support the model that dietary restriction increases life span by a mechanism that does not require HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 995) |
11 |
OB_003774 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
flcn-1 |
Caenorhabditis elegans |
|
loss of function |
ok975 |
unknown |
unknown |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
HT115 |
unknown |
unknown |
|
|
|
increased |
8.49% |
16.22 |
14.95 |
days |
mean |
20 |
℃ |
|
Depletion of hif-1 with RNAi abrogated the effect of loss of flcn-1 on lifespan suggesting that longevity in the flcn-1 deficient worms depends on and may be mediated by hif-1 |
Gharbi et al. |
2013 |
23566034 |
doi:10.1111/acel.12081 |
Lifespan Observations Database (ID: 5355) |
12 |
OB_000041 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
increased |
7.11% |
22.6 |
21.1 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1037) |
13 |
OB_003775 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
flcn-1 |
Caenorhabditis elegans |
|
loss of function |
ok975 |
unknown |
unknown |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
HT115 |
unknown |
unknown |
|
|
|
increased |
5.41% |
19.5 |
18.5 |
days |
max |
20 |
℃ |
|
Depletion of hif-1 with RNAi abrogated the effect of loss of flcn-1 on lifespan suggesting that longevity in the flcn-1 deficient worms depends on and may be mediated by hif-1 |
Gharbi et al. |
2013 |
23566034 |
doi:10.1111/acel.12081 |
Lifespan Observations Database (ID: 5356) |
14 |
OB_004290 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
|
|
|
none |
4.72% |
22.2 |
21.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 had no significant effect on life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 985) |
15 |
OB_000040 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
none |
3.69% |
25.3 |
24.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1036) |
16 |
OB_004294 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
|
|
|
none |
3.02% |
23.9 |
23.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 had no significant effect on life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 989) |
17 |
OB_000025 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
none |
1.22% |
24.8 |
24.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1022) |
18 |
OB_000001 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
none |
0.00% |
24.4 |
24.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1000) |
19 |
OB_000039 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
none |
-0.93% |
21.4 |
21.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1035) |
20 |
OB_000026 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
none |
-1.66% |
23.7 |
24.1 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1023) |
21 |
OB_004305 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
none |
-2.12% |
18.5 |
18.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 999) |
22 |
OB_000024 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
none |
-2.76% |
21.1 |
21.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1021) |
23 |
OB_004293 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
|
|
|
none |
-3.23% |
21 |
21.7 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 had no significant effect on life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 988) |
24 |
OB_004286 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
|
|
|
none |
-3.57% |
18.9 |
19.6 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 had no significant effect on life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 981) |
25 |
OB_004296 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
|
|
|
none |
-3.65% |
21.1 |
21.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 had no significant effect on life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 990) |
26 |
OB_000002 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
none |
-4.23% |
18.1 |
18.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1001) |
27 |
OB_000004 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
none |
-4.25% |
20.3 |
21.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1003) |
28 |
OB_004288 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
|
|
|
none |
-4.66% |
18.4 |
19.3 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 had no significant effect on life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 983) |
29 |
OB_004303 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
none |
-4.74% |
20.1 |
21.1 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of hif-1 had no significant effect on life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 997) |
30 |
OB_004289 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
|
|
|
none |
-4.78% |
21.9 |
23 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 had no significant effect on life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 984) |
31 |
OB_004292 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
|
|
|
none |
-4.98% |
22.9 |
24.1 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 had no significant effect on life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 987) |
32 |
OB_004304 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
decreased |
-5.98% |
17.3 |
18.4 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of hif-1 had no significant effect on life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 998) |
33 |
OB_000003 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
decreased |
-8.37% |
19.7 |
21.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1002) |
34 |
OB_004287 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
|
|
|
decreased |
-8.50% |
18.3 |
20 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 had no significant effect on life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 982) |
35 |
OB_004297 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
|
|
|
decreased |
-9.46% |
20.1 |
22.2 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 shortened life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 991) |
36 |
OB_000023 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
decreased |
-10.05% |
19.7 |
21.9 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 1020) |
37 |
OB_004291 |
Caenorhabditis elegans |
N2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
|
|
|
decreased |
-10.20% |
22 |
24.5 |
days |
mean |
20 |
℃ |
hermaphrodite |
Deletion of hif-1 decreased life span. |
Mehta et al. |
2009 |
19372390 |
doi:10.1126/science.1173507 |
Lifespan Observations Database (ID: 986) |