Release 1 - Aug 15, 2014

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Gene: MSRA - Drosophila melanogaster

Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Ageing relevance by experimental analysis: yes
Defined by: Gene Symbol, Species
Ageing relevance by experimental analysis: yes
Defined by: Gene Symbol, Species

Summary

Gene Symbol : MSRA
NCBI Gene ID :
Species : Drosophila melanogaster
Gene Synonyms :
Gene Homologs :
Ageing Relevance Analysis :
Observation Type Count Ageing Relevance Source
Ageing Phenotype Observation—Data Type 2
Lifespan Effect
increased 1 yes (Exp. Analysis) [Lifespan Observations Database icon]Lifespan Observations Database
Total 1
Ageing Factor Stable ID : AF_008660
Download : [xml icon]XML

* Ageing factors from different sources are merged, if possible. Genes are merged by their NCBI Gene ID, if assigned and otherwise by the combination of the gene symbol and species name. The latter approach is less reliable than using the NCBI Gene ID. This gene has no NCBI gene ID assigned. Therefore it is possible that it is already included in AgeFactDB under a different gene symbol or NCBI Gene ID. The missing NCBI Gene ID is also the reason for fact that one or more possible synonym groups are found.

Protein Information

no protein information available

Observations

Ageing Phenotype

Data Type 1

no ageing phenotype observation—data type 1 available

Data Type 2

Ageing Relevance:
  • yes (Exp. Analysis)
  • yes, but no ageing factor assigned (Exp. Analysis)
  • no (Exp. Analysis)
  • putative (Comp. Analysis)
Organism Ageing Factor Lifespan Observation Reference
# Observation Stable ID Species Strain Gene Compound Other Ageing Factor Significant Lifespan Effect Change Observed Lifespan Reference Lifespan Lifespan Unit Measure Temperature Temperature Unit Sex/Mating Type Description Author Year PubMed DOI Source
1 OB_003883 Drosophila melanogaster
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
MSRA Drosophila melanogaster over-expression - unknown unknown
increased 70.00% Overexpression in the nervous system extended lifespan by up to 70%. Other phenotypes: Overexpression in the nervous system increased resistance to oxidative stress, and delayed the onset of senescence-induced decline in activity levels and reproductive capacity. Ruan et al. 2002 11867705 [DOI icon]doi:10.1073/pnas.032671199 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 600)
2 OB_000090 Drosophila melanogaster
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
MSRA Drosophila melanogaster over-expression - unknown unknown
increased Flies engineered to overexpress methionine sulfoxide reductase A (MSRA) have a median lifespan up to 70% longer than parental controls that don''t overexpress the protein. Other phenotypes: Flies that overexpress MSRA retain reproductive capacity longer than parental controls that don''t overexpress the protein, and are more active, as measured by a climbing assay. Ruan et al. 2002 11867705 [DOI icon]doi:10.1073/pnas.032671199 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 108)

Homology Analysis

no homology analysis observation available

Sequences

no sequence information available

References

MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.

  1. Ruan H, Tang XD, Chen ML, Joiner ML, Sun G, Brot N, Weissbach H, Heinemann SH, Iverson L, Wu CF, Hoshi T, Chen ML, Joiner MA, Heinemann SH:
    High-quality life extension by the enzyme peptide methionine sulfoxide reductase.
    Proc Natl Acad Sci USA. 2002; 99: 2748-53.
    [PubMed icon]PubMed (ID: 11867705), [PubMed icon]PubMed Central (ID: PMC122419), [DOI icon]doi:10.1073/pnas.032671199
    MeSH Terms: Longevity/physiology; Oxidoreductases/physiology

Sources

Ageing-related Data Sources

Additional Data Sources