1 |
OB_003098 |
Saccharomyces cerevisiae |
YPK9 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
PHB1 |
Saccharomyces cerevisiae |
853033 |
deletion / null |
- |
unknown |
unknown |
|
|
|
none |
-3.54% |
19.1 |
19.8 |
divisions |
mean |
30 |
℃ |
mata |
Deletion of PHB1 does not alter yeast replicative lifespan. |
Kirchman et al. |
2003 |
14739993 |
doi:0350041039 |
Lifespan Observations Database (ID: 4479) |
2 |
OB_003101 |
Saccharomyces cerevisiae |
YPK9 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
PHB1 |
Saccharomyces cerevisiae |
853033 |
deletion / null |
- |
unknown |
unknown |
PHB2 |
Saccharomyces cerevisiae |
853146 |
deletion / null |
- |
unknown |
unknown |
|
|
|
none |
-4.55% |
18.9 |
19.8 |
divisions |
mean |
30 |
℃ |
mata |
Deletion of PHB2 does not alter yeast replicative lifespan. |
Kirchman et al. |
2003 |
14739993 |
doi:0350041039 |
Lifespan Observations Database (ID: 4481) |
3 |
OB_003109 |
Saccharomyces cerevisiae |
rho0 ras2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
PHB1 |
Saccharomyces cerevisiae |
853033 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-7.66% |
19.3 |
20.9 |
divisions |
mean |
30 |
℃ |
mata |
Deletion of PHB1 does not alter replicative lifespan in the absense of mitochondrial DNA (rho0) and RAS2. |
Kirchman et al. |
2003 |
14739993 |
doi:0350041039 |
Lifespan Observations Database (ID: 4489) |
4 |
OB_003112 |
Saccharomyces cerevisiae |
rho0 ras2 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
PHB1 |
Saccharomyces cerevisiae |
853033 |
deletion / null |
- |
unknown |
unknown |
PHB2 |
Saccharomyces cerevisiae |
853146 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-7.66% |
19.3 |
20.9 |
divisions |
mean |
30 |
℃ |
mata |
Deletion of PHB1 does not alter replicative lifespan in the absense of mitochondrial DNA (rho0) and RAS2. |
Kirchman et al. |
2003 |
14739993 |
doi:0350041039 |
Lifespan Observations Database (ID: 4491) |
5 |
OB_005719 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
PHB1 |
Saccharomyces cerevisiae |
853033 |
Deletion |
- |
wildtype |
yes |
|
|
|
decreased |
-20.00% |
|
|
|
unknown |
|
|
|
Replicative lifespan decreased by 20% |
Piper et al. |
2002 |
12882345 |
|
GenAge |
6 |
OB_003107 |
Saccharomyces cerevisiae |
YPK9 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
PHB1 |
Saccharomyces cerevisiae |
853033 |
deletion / null |
- |
unknown |
unknown |
RAS2 |
Saccharomyces cerevisiae |
855625 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-30.66% |
14.7 |
21.2 |
divisions |
mean |
30 |
℃ |
mata |
Deletion of both PHB1 and RAS2 decreases replicative lifespan by 30.7%, which is no shorter than deletion of RAS2 alone. |
Kirchman et al. |
2003 |
14739993 |
doi:0350041039 |
Lifespan Observations Database (ID: 4487) |
7 |
OB_003103 |
Saccharomyces cerevisiae |
YPK9 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
PHB1 |
Saccharomyces cerevisiae |
853033 |
deletion / null |
- |
unknown |
unknown |
rho0 |
Saccharomyces cerevisiae |
|
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-31.74% |
11.4 |
16.7 |
divisions |
mean |
30 |
℃ |
mata |
Deletion of PHB1 decreases replicative lifespan by 31.7% in the absense of mitochondrial DNA (rho0). |
Kirchman et al. |
2003 |
14739993 |
doi:0350041039 |
Lifespan Observations Database (ID: 4483) |
8 |
OB_004132 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
PHB1 |
Saccharomyces cerevisiae |
853033 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-47.00% |
|
26.1 |
|
mean |
30 |
℃ |
|
The phb1 deletion from the MATalpha haploid yeast orf deletion collection had a shortened replicative life span relative to wild type BY4742 cells. |
Kaeberlein et al. |
2005 |
15722108 |
doi:10.1016/j.mad.2004.10.007 |
Lifespan Observations Database (ID: 826) |
9 |
OB_003105 |
Saccharomyces cerevisiae |
YPK9 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
PHB1 |
Saccharomyces cerevisiae |
853033 |
deletion / null |
- |
unknown |
unknown |
PHB2 |
Saccharomyces cerevisiae |
853146 |
deletion / null |
- |
unknown |
unknown |
rho0 |
Saccharomyces cerevisiae |
|
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-58.08% |
7 |
16.7 |
divisions |
mean |
30 |
℃ |
mata |
Deletion of both PHB1 and PHB2 decreases replicative lifespan by 58.1% in the absense of mitochondrial DNA (rho0). |
Kirchman et al. |
2003 |
14739993 |
doi:0350041039 |
Lifespan Observations Database (ID: 4485) |
10 |
OB_000098 |
Saccharomyces cerevisiae |
S150-2B |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
PHB1 |
Saccharomyces cerevisiae |
853033 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
|
|
|
|
|
|
|
|
Deletion of PHB1 results in approximately 20% shorter lifespan. Other phenotypes: Deletion of both PHB1 and PHB2 results in a life span that is approximately 40% shorter than wild type. Phenotypic changes characteristic of aging cells may suggest that PHB1/PHB2 mutants undergo premature aging, not simply reduction in viability. These changes include lengthening of cell cycle and characteristic morphological changes [ 9259555]. No reduction in stress resistance or bulk growth rate. A strong defect in mitochondrial potential was detected in the phb1 phb2 double mutant, and a slight defect in the phb1 single mutant. Deletion of PHB1 is synthetically lethal [ 9259555]. |
Coates et al. |
1997 |
9259555 |
|
Lifespan Observations Database (ID: 10) |
11 |
OB_003341 |
Saccharomyces cerevisiae |
PSY316AT |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
PHB1 |
Saccharomyces cerevisiae |
853033 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
|
|
|
si |
|
30 |
℃ |
|
Loss of either prohibitin gene decreased both the mean and the maximal life spans. This study focused on this shortening of yeast replicative life span with prohibitin loss. We show that it still occurs in cells lacking an assembled respiratory chain. Instead, the senescencing mother cells of phb null strains display pronounced defects in mitochondrial morphology and segregation. |
Piper et al. |
2002 |
12882345 |
|
Lifespan Observations Database (ID: 4762) |
12 |
OB_005718 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
PHB1 |
Saccharomyces cerevisiae |
853033 |
Deletion |
- |
wildtype |
yes |
|
|
|
decreased |
|
|
|
|
unknown |
|
|
|
Deletion results in a reduction in mean and maximum replicative lifespan and a defect in mitochondrial membrane potential. |
Coates et al. |
1997 |
9259555 |
|
GenAge |