Gene: GCN2 - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | GCN2 | ||||||||||||||||||||||||||||
NCBI Gene ID | : | 851877 | ||||||||||||||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||||||||||||||
Gene Synonyms | : | |||||||||||||||||||||||||||||
Gene Homologs | : | AgaP_AGAP012368 (Anopheles gambiae) | AGOS_AAL083W (Eremothecium gossypii) | EIF2AK4 (Bos taurus) | EIF2AK4 (Canis lupus familiaris) | eif2ak4 (Danio rerio) | EIF2AK4 (Gallus gallus) | EIF2AK4 (Homo sapiens) | EIF2AK4 (Macaca mulatta) | Eif2ak4 (Mus musculus) | EIF2AK4 (Pan troglodytes) | gcn-2 (Caenorhabditis elegans) | Gcn2 (Drosophila melanogaster) | GCN2 (Saccharomyces cerevisiae) | gcn2 (Schizosaccharomyces pombe) | KLLA0C10802g (Kluyveromyces lactis) | MGG_08643 (Magnaporthe oryzae) | NCU01187 (Neurospora crassa) | ||||||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_008685 | ||||||||||||||||||||||||||||
Download | : | XML |
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | |||||||||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | |||||||||||||||||||||
1 | OB_000253 | Saccharomyces cerevisiae | BY4742 |
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increased | 26.62% | 33.3 | 26.3 | divisions | mean | 30 | ℃ | matalpha | Deletion of GCN4 but not deletion of GCN2 suppresses replicative life span extension from deletion of RPL20B. | Steffen et al. | 2008 | 18423200 | doi:10.1016/j.cell.2008.02.037 | Lifespan Observations Database (ID: 1257) | |||||||||||||||||||||||
2 | OB_007467 | Saccharomyces cerevisiae |
|
increased | 20.00% | unknown | Replicative lifespan decreased by by 10-20% in both alpha and a strains | Managbanag et al. | 2008 | 19030232 | doi:10.1371/journal.pone.0003802 | GenAge | ||||||||||||||||||||||||||||||
3 | OB_000254 | Saccharomyces cerevisiae | BY4742 |
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decreased | -8.37% | 24.1 | 26.3 | divisions | mean | 30 | ℃ | matalpha | Deletion of GCN4 but not deletion of GCN2 suppresses replicative life span extension from deletion of RPL20B. | Steffen et al. | 2008 | 18423200 | doi:10.1016/j.cell.2008.02.037 | Lifespan Observations Database (ID: 1258) | |||||||||||||||||||||||
4 | OB_007466 | Saccharomyces cerevisiae |
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decreased | -10.00% | unknown | Replicative lifespan decreased by 10% in a strain | Smith et al. | 2008 | 18340043 | doi:10.1101/gr.074724.107 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_009324 | 1 | The HomoloGene homology group 40891 contains 1 gene with experimental evidence for ageing relevance (GCN2 - Saccharomyces cerevisiae) and 16 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 40891 |
Sequences
no sequence information available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Smith ED, Tsuchiya M, Fox LA, Dang N, Hu D, Kerr EO, Johnston ED, Tchao BN, Pak DN, Welton KL, Promislow DE, Thomas JH, Kaeberlein M, Kennedy BK:
Quantitative evidence for conserved longevity pathways between divergent eukaryotic species.
Genome Res. 2008; 18: 564-70.
PubMed (ID: 18340043), PubMed Central (ID: PMC2279244), doi:10.1101/gr.074724.107
MeSH Terms: Caenorhabditis elegans/genetics; Longevity/genetics; Saccharomyces cerevisiae/genetics - Steffen KK, MacKay VL, Kerr EO, Tsuchiya M, Hu D, Fox LA, Dang N, Johnston ED, Oakes JA, Tchao BN, Pak DN, Fields S, Kennedy BK, Kaeberlein M:
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.
Cell. 2008; 133: 292-302.
PubMed (ID: 18423200), PubMed Central (ID: PMC2749658), doi:10.1016/j.cell.2008.02.037
MeSH Terms: DNA-Binding Proteins/physiology; Ribosome Subunits, Large, Eukaryotic/physiology; Saccharomyces cerevisiae Proteins/physiology; Saccharomyces cerevisiae/physiology; Transcription Factors/physiology - Managbanag JR, Witten TM, Bonchev D, Fox LA, Tsuchiya M, Kennedy BK, Kaeberlein M:
Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity.
PLoS ONE. 2008; 3: e3802.
PubMed (ID: 19030232), PubMed Central (ID: PMC2583956), doi:10.1371/journal.pone.0003802
MeSH Terms: Cell Physiological Phenomena/genetics; Gene Regulatory Networks; Saccharomyces cerevisiae/cytology; Saccharomyces cerevisiae/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- HomoloGene
- NCBI Taxonomy
- PubMed